A5028556227- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Natural Compounds in Disease Treatment
- Drug Transport and Resistance Mechanisms
- Analytical Methods in Pharmaceuticals
- Ginseng Biological Effects and Applications
- Tryptophan and brain disorders
- Analytical Chemistry and Chromatography
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- Autophagy in Disease and Therapy
- Bone Metabolism and Diseases
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Schizophrenia research and treatment
- Pharmacogenetics and Drug Metabolism
- Lipoproteins and Cardiovascular Health
- Bipolar Disorder and Treatment
- Bone health and treatments
- Genomics, phytochemicals, and oxidative stress
- Neuroscience and Neuropharmacology Research
- Phytochemistry and Bioactivity Studies
- Bioactive Compounds and Antitumor Agents
- Medicinal Plants and Bioactive Compounds
Second Xiangya Hospital of Central South University
2015-2024
Central South University
2015-2024
Xiangya Hospital Central South University
2006-2022
Changsha University
2020
Ministry of Health of the Russian Federation
2006
Early findings propose that impaired neurotransmission in the brain plays a key role pathophysiology of schizophrenia. Recent advances understanding its multiple etiologies and pathogenetic mechanisms provide more speculative hypotheses focused on even broader somatic systems. Using targeted tandem mass spectrometry (MS/MS)-based metabolomic platform, we compared metabolic signatures consisting monoamine amino acid neurotransmitter (NT) metabolites plasma/urine simultaneously between...
Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) is the central regulator of cellular responses electrophilic/oxidative stress, which serves critical role in maintenance normal cardiac function. Tanshinone IIA (Tan IIA) has previously been reported protect against DOX‑induced cardiotoxicity. The aim present study was elucidate...
Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquitigenin (ISL) has been reported to protect against TP-induced liver injury, but mechanisms are not fully elucidated. This study aims explore role nuclear transcription factor E2-related 2 (Nrf2) and hepatic transporters in hepatotoxicity reversal effect ISL on it. TP treatment caused both cytotoxicity L02 hepatocytes acute injury mice. Particularly, led a disorder bile...
Triptolide (TP), an active ingredient of Tripterygium wilfordii Hook f., possesses a wide range biological activities. Oxidative stress likely plays role in TP‐induced hepatotoxicity. Isoliquiritigenin (ISL) and glycyrrhetinic acid (GA) are potent hepatoprotection agents. The aim the present study was to investigate whether Nrf2 pathway is associated with protective effects ISL GA against oxidative or not. HepG2 cells were treated TP (50 nM) for 24 h after pretreatment (5, 10, 20 μ M) 12 h,...
Schizophrenia (SZ) is considered to be a multifactorial brain disorder with defects involving many biochemical pathways. Patients SZ show variable responses current pharmacological treatments of because the heterogeneity this disorder. Stress has significant role in pathophysiological pathways and therapeutic SZ. Atypical antipsychotic drugs (AAPDs) can modulate stress response hypothalamic–pituitary–adrenal (HPA) axis exert effects on by targeting prefrontal cortex (PFC) hippocampus. To...
Triptolide (TP) is an active ingredient isolated from Tripterygium wilfordii Hook. f. (TWHF), which a traditional herbal medicine widely used for the treatment of rheumatoid arthritis and autoimmune disease in clinic. However, its adverse reactions hepatotoxicity nephrotoxicity have been frequently reported limited clinical application. The aim this study was to investigate mechanism glycyrrhetinic acid (GA) effecting on elimination TP HK-2 cells role efflux transporters P-gp multidrug...
To investigate the potential role of nuclear factor erythroid 2-related 2 (Nrf2) in licorice ethanol extract (LEE) against triptolide- (TP-) induced hepatotoxicity, HepG2 cells were exposed to LEE (30, 60, and 90 mg·L-1) for 12 h then treated with TP (50 nM) 24 h. Besides, an acute liver injury model was established ICR mice by a single dose (1.0 mg·kg-1, i.p.). Relevant oxidant antioxidant mediators analyzed. led obvious oxidative stress as evidenced increasing levels ROS decreasing GSH...
Background and Objective: Apolipoprotein E (APOE) plays important roles in lipoprotein metabolism cardiovascular disease. Evidence suggests the APOE gene epsilon2/epsilon3/epsilon4 (ε2/ε3/ε4) polymorphisms might be associated with susceptibility of coronary artery disease (CAD) patients type 2 diabetes mellitus (T2DM). However, no clear consensus has yet been established. Therefore, aim this meta-analysis is to provide a precise conclusion on potential association between ε2/ε3/ε4 risk CAD...
Isoliquiritigenin, a flavonoid found in licorice, has been considered as an antioxidive and hepato-protective agent. Recent studies have shown that possible mechanism for triptolide-induced hepatotoxicity is related to oxidative damage induced by reactive oxygen species. This study was done investigate the protection effect of isoliquiritigenin against involved. An acute liver injury model established intraperitoneal injection triptolide (1.0 mg · kg-1) mice. Different doses (12.5, 25 50...
Abstract The neurotoxicity of Semen Strychni has been reported recently in several clinical cases. Therefore, this study was conducted to investigate the role HMGB1 a model induced by and assess potential alleviating effects glycyrrhizic acid (GA), which is associated with regulation release. Forty-eight SD rats were intraperitoneally injected extract (175 mg/kg), followed oral administration GA (50 mg/kg) for four days. After treatment SS GA, neuronal degeneration, apoptosis, necrosis...
Semen Strychni has long been used for the treatment of rheumatoid arthritis, facioplegia and myasthenia gravis due to its anti-inflammation anti-nociceptive properties in China. However, fatal neurotoxicity limited wider clinical application. To investigate acute toxicity induced by detoxification liquorice, we evaluated inflammation, oxidative stress translocation high mobility group box 1 (HMGB1) rats. As a result, there were obvious inflammation hippocampus after extracts (STR) Liquorice...
Semen Strychni is known for its treatment of rheumatic arthritis with a low therapeutic index. Liquorice contributes lot in herb detoxification according to the traditional Chinese medicine theory. A simple, rapid, and sensitive liquid chromatography-mass spectrometric method (LC-MS) was developed validated simultaneous determination main bioactive ingredients liquorice rat plasma. Using moclobemide cyproterone acetate as internal standards, analytes were pretreated via protein precipitation...
Tripterygium wilfordii has exihibited multiple pharmacological activities, such as anti-inflammatory, immune modulation, anti-tumor and anti-fertility. T. have been used for the therapy of inflammation autoimmune diseases including rheumatoid arthritis, complex nephritis systemic lupus erythematosus clinically. However, it is well known that small margin between therapeutic toxic doses could cause serious injury on digestive, reproductive urogenital systems. Among all organs, liver one most...