A5100319830- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Cardiac electrophysiology and arrhythmias
- Probiotics and Fermented Foods
- Poisoning and overdose treatments
- Opioid Use Disorder Treatment
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Ion channel regulation and function
- Antibiotic Resistance in Bacteria
- Oral and Maxillofacial Pathology
- Anesthesia and Sedative Agents
- Animal Nutrition and Physiology
- Computational Drug Discovery Methods
- dental development and anomalies
- Statistical Methods in Clinical Trials
- PARP inhibition in cancer therapy
- ECG Monitoring and Analysis
- Transgenic Plants and Applications
- Bacterial Identification and Susceptibility Testing
- Escherichia coli research studies
- Rabbits: Nutrition, Reproduction, Health
- Chemotherapy-induced cardiotoxicity and mitigation
- Medical Imaging and Pathology Studies
- Nutrition, Health and Food Behavior
Center for Drug Evaluation and Research
2016-2025
Third Hospital of Hebei Medical University
2025
Hebei Medical University
2025
Translational Sciences (United States)
2025
United States Food and Drug Administration
2015-2024
Institute of Subtropical Agriculture
2021-2024
Northeast Agricultural University
2023
Chongqing Electromechanical Holdings (China)
2023
Shandong University
2022
Nanjing Agricultural University
2021
The current proarrhythmia safety testing paradigm, although highly efficient in preventing new torsadogenic drugs from entering the market, has important limitations that can restrict development and use of valuable therapeutics. CiPA (Comprehensive vitro Proarrhythmia Assay) proposes to overcome these by evaluating drug effects on multiple cardiac ion channels using data a predictive silico model adult human ventricular myocyte. A set with known clinical torsade de pointes risk was selected...
The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a global initiative intended to improve drug proarrhythmia risk assessment using new paradigm of mechanistic assays. Under the CiPA paradigm, relative drug-induced Torsade de Pointes (TdP) assessed an silico model human ventricular action potential (AP) that integrates pharmacology data from multiple ion channels. Thus modeling predictions cardiac liability will depend critically on variability data, and uncertainty quantification (UQ)...
Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) is the central regulator of cellular responses electrophilic/oxidative stress, which serves critical role in maintenance normal cardiac function. Tanshinone IIA (Tan IIA) has previously been reported protect against DOX‑induced cardiotoxicity. The aim present study was elucidate...
Abstract Background Emergence of antibiotic resistance is a global public health concern. The relationships between use, the gut community composition, normal physiology and metabolism, individual are still being defined. Shifts in composition bacteria, genes (ARGs) mobile genetic elements (MGEs) after treatment not well-understood. Methods This project used next-generation sequencing, custom-built metagenomics pipeline differential abundance analysis to study effect monotherapy on resistome...
In response to a surge of deaths from synthetic opioid overdoses, there have been increased efforts distribute naloxone products in community settings. Prior research has assessed the effectiveness hospital setting; however, it is challenging assess dosing regimens community/first-responder setting, including reversal respiratory depression effects fentanyl and its derivatives (fentanyls). Here, we describe development validation mechanistic model that combines mu receptor binding kinetics,...
hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and lack statistical quantification experimental variability. Since the new cardiac paradigm being discussed International Council for Harmonisation promotes tighter integration nonclinical clinical data risk assessment, more systematic approach estimate needed. A cross-industry study was...
Importance Questions have emerged as to whether standard intranasal naloxone dosing recommendations (ie, 1 dose with readministration every 2-3 minutes if needed) are adequate in the era of illicitly manufactured fentanyl and its derivatives (hereinafter, fentanyl). Objective To compare plasma concentrations between different repeat strategies estimate their effect on overdose. Design, Setting, Participants This unblinded crossover randomized clinical trial was conducted healthy participants...
In response to increased illicit use of synthetic opioids, various μ‐receptor antagonist formulations, with varied pharmacological characteristics, have been and are being developed. To understand how pharmacologic characteristics such as absorption rate clearance affect reversal in treating community opioid overdose, we used our previously published translational model. We adapted this model vitro receptor binding data clinical pharmacokinetic three intranasal nalmefene formulations along...
This retrospective study aimed to explore the effect of erector spinae plane block (ESPB) on gastrointestinal function in patients after traumatic lumbar fracture surgery and effects different levels approach. Clinical data were retrospectively analyzed from electronic medical records who underwent spine (September 2022-June 2023). Eligible divided into three groups: group L (bilateral ESPB at L3 level), T T12 level) C (no block). The primary outcomes incidence time occurrence postoperative...
Abstract Introduction According to the Centers for Disease Control’s 2015 Hospital Acquired Infection Prevalence Survey, 1 in 31 hospital patients was infected with at least one nosocomial pathogen while being treated unrelated issues. Many studies associate antibiotic administration infection occurrence. However, our knowledge, there is little no direct evidence of selecting opportunistic pathogens. Aim This study aims confirm gut microbiota shifts an animal model treatment determine...
We thank Dr. Pattullo1 and Drs. Milas Varon2 for their interest careful reading of our article on the use naloxone in reversal an opioid overdose as might occur community setting United States.3 Individuals that are commonly found a state unconsciousness, these victims, recently discussed general media,4 often positive fentanyl well other substances (e.g., methamphetamine, xylazine, cannabis, or gabapentin), affect not only breathing but also level consciousness. Because illicit drugs...
Despite a rapid increase in pediatric mortality rate from prescription and illicit opioids, there is limited research on the dose-dependent impact of opioids respiratory depression children, leading cause opioid-associated death. In this article, we extend previously developed translational model to cover populations by incorporating age-dependent pharmacokinetic, pharmacodynamic, physiological changes compared adults. Our reproduced previous perioperative clinical findings that adults...
Abstract Deep learning neural networks are often described as black boxes, it is difficult to trace model outputs back inputs due a lack of clarity over the internal mechanisms. This even true for those designed emulate mechanistic models, which simply learn mapping between and ignoring underlying processes. Using studying pharmacological interaction opioids naloxone proof-of-concept example, we demonstrated that by reorganizing networks’ layers mimic structure model, possible achieve better...