A5053698852- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Effects and risks of endocrine disrupting chemicals
- Cardiac electrophysiology and arrhythmias
- Toxic Organic Pollutants Impact
- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Sperm and Testicular Function
- Pharmacological Receptor Mechanisms and Effects
- Global Health Care Issues
- Neuroscience and Neural Engineering
- Climate Change and Health Impacts
- Receptor Mechanisms and Signaling
- Reproductive Biology and Fertility
- Neurotransmitter Receptor Influence on Behavior
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Cardiac Arrhythmias and Treatments
- Genomic variations and chromosomal abnormalities
- Nicotinic Acetylcholine Receptors Study
- Systemic Lupus Erythematosus Research
- Cardiac pacing and defibrillation studies
- Hormonal and reproductive studies
Anhui Medical University
2014-2025
University of South China
2023-2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2019-2023
United States Military Academy
2015-2021
Bristol-Myers Squibb (United States)
2020
Queensland University of Technology
2017
Eli Lilly (United States)
2002-2003
Columbia University
1998-1999
Allegheny College
1997-1998
National Institutes of Health
1998
hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and lack statistical quantification experimental variability. Since the new cardiac paradigm being discussed International Council for Harmonisation promotes tighter integration nonclinical clinical data risk assessment, more systematic approach estimate needed. A cross-industry study was...
Arsenic (As) is an environmental metalloid. Previous studies have demonstrated that As exposure resulted in decline of sperm quality. This study aimed to investigate the impact on blood-testis barrier (BTB) a mouse model. Four-week-old male mice were exposed NaAsO2 (1 or 15 mg/L) for 6 weeks. Our results found disrupted BTB and reduced counts adult mice. activated integrated stress response (ISR) downregulated junction protein testes Sertoli cells. Ribosome profiling sequencing (Ribo-seq)...
The goal of this research consortium including Janssen, MSD, Ncardia, FNCR/LBR, and Health Environmental Sciences Institute (HESI) was to evaluate the utility an additional in vitro assay technology detect potential drug-induced long QT torsade de pointes (TdP) risk by monitoring cytosolic free Ca2+ transients human stem-cell-derived cardiomyocytes (hSC-CMs). proarrhythmic risks 28 comprehensive proarrhythmia (CiPA) drugs linked low, intermediate, high clinical TdP were evaluated a blinded...
A gas chromatography-mass spectrometry assay was developed and validated for the simultaneous determination of phthalates adipates in human serum. The studied were dimethyl phthalate, diethyl dibutyl benzylbutyl di-2-ethylhexyl di-n-octyl adipate, diisobutyl bis(2-butoxyethyl) adipate with diisooctyl phthalate as internal standard. extraction cleaning up procedure carried out solid-phase cartridges containing butylamine groups, which showed efficiencies over 88% each analyte calibration...
3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable Q3W (once every 3 weeks) oral parenteral dosing. A diamide IDO was discovered through an automated ligand identification system (ALIS). Installation fluorophenyl dramatically improved potency. Identification biaryl moiety unconventional amide isostere addressed metabolic...