A5101795309- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Ginseng Biological Effects and Applications
- Medicinal Plants and Bioactive Compounds
- Endoplasmic Reticulum Stress and Disease
- Plant tissue culture and regeneration
- Insect and Arachnid Ecology and Behavior
- Transgenic Plants and Applications
- Photosynthetic Processes and Mechanisms
- Malaria Research and Control
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Animal Genetics and Reproduction
- Heat shock proteins research
- Biochemical effects in animals
- Lepidoptera: Biology and Taxonomy
- Plant Virus Research Studies
- Autophagy in Disease and Therapy
- Genetic diversity and population structure
- Plant and animal studies
- Adipose Tissue and Metabolism
- Flavonoids in Medical Research
- Vitamin C and Antioxidants Research
Central South University
2020-2024
Second Xiangya Hospital of Central South University
2020-2024
Nankai University
2023
Xiangya Hospital Central South University
2022
Changsha University
2020
Shaanxi Normal University
2015-2019
Shihezi University
2008
Triphenyl phosphate (TPHP) is a widely used flame retardant and plasticizer has been detected extensively in environmental media, wildlife human bodies. Several epidemiological animal studies have revealed that TPHP exposure positively associated with glucose homeostasis disruption diabetes. However, the effects of on hepatic underlying mechanisms remain unclear. The present work aimed to investigate cytotoxicity metabolism its metabolite diphenyl (DPHP) within hepatocytes. cell viability...
Abstract The neurotoxicity of Semen Strychni has been reported recently in several clinical cases. Therefore, this study was conducted to investigate the role HMGB1 a model induced by and assess potential alleviating effects glycyrrhizic acid (GA), which is associated with regulation release. Forty-eight SD rats were intraperitoneally injected extract (175 mg/kg), followed oral administration GA (50 mg/kg) for four days. After treatment SS GA, neuronal degeneration, apoptosis, necrosis...
Semen Strychni has long been used for the treatment of rheumatoid arthritis, facioplegia and myasthenia gravis due to its anti-inflammation anti-nociceptive properties in China. However, fatal neurotoxicity limited wider clinical application. To investigate acute toxicity induced by detoxification liquorice, we evaluated inflammation, oxidative stress translocation high mobility group box 1 (HMGB1) rats. As a result, there were obvious inflammation hippocampus after extracts (STR) Liquorice...
Mild hypothermia can induce apoptotic cell death in many cancer cells, but the underlying mechanisms remain unclear. In a genetic screen Caenorhabditis elegans , we found that impaired endoplasmic reticulum unfolded protein response (UPR ER ) increased animal survival after cold shock. Consistently, normal human lung decreasing culture temperature from 37 to 30 °C activated UPR and promoted death. However, adenocarcinoma cells were induction resistant hypothermia‐induced Mechanistically,...
Semen Strychni, a traditional Chinese medicine (TCM), has been widely used to treat paraplegia, facial nerve palsy and myasthenia gravis. However, its clinical application is greatly limited due fatal toxicity. To investigate the acute toxicity of Strychni detoxification effect licorice, high-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) based urinary metabolomics method was developed in this study. After intraperitoneal injection rats...
The complete mitochondrial genome of the Scarlet Tiger moth Callimorpha dominula (Insecta: Lepidoptera: Arctiidae) has been reconstructed from whole-genome Illumina sequencing data. This circular is 15 496 bp in size, and contains 13 protein-coding genes (PCGs), 22 transfer RNAs (tRNAs), two ribosomal (rRNAs), one A + T-rich D-loop or control region. Most PCGs are initiated with ATN codons, except for COX1 unusual CGA as its initiation codon. Four (COX1, COX2, ND3, ND4) terminated incomplete...
Acute neurotoxicity of Semen Strychni can result in sudden death epilepsy. The detoxification method and mechanism acute poisoning have not been clarified. This experiment focused on the alleviation effects isoliquiritigenin. rats were intraperitoneally injected with extract (125 mg/kg), followed by oral administration isoliquiritigenin (50 mg/kg) for 7 days. FJ-B staining was used to evaluate degree injury hippocampus neurons. concentration monoamines, amino acids, choline...
Anopheles funestus is a major malaria vector in Africa. In this study, its complete mitochondrial genome was assembled from high-throughput sequencing reads. The circular 15,403 bp long with an A + T-biased base composition and harbors 37 genes (including 13 protein-coding genes/PCGs, 22 tRNAs, two rRNAs) one control region. PCGs are initiated ATN, GTG, TTG, or CGA codons terminated either TAA TA/T codons. Phylogenetic analysis added support to the current taxonomic framework of genus...
Abstract Backgrounds : In recent years, the neurotoxicity of Semen Strychni was reported in many clinical cases. Hence，this study conducted to investigate role HMGB1 model induced by and alleviation glycyrrhizic acid, which is related regulation release. Methods The rats were intraperitoneally injected with extract (175mg/kg), followed oral administration ofglycyrrhizic acid (50 mg/kg) for 4 days. After treatment, neuronal degeneration, apoptosis, necrosis observed Nissl, FJB, Tunel. ELISA...