A5033275911- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Biomedical Research and Pathophysiology
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Synthesis and Biological Activity
- Natural Compounds in Disease Treatment
- Plant chemical constituents analysis
- Inflammasome and immune disorders
- Curcumin's Biomedical Applications
- Signaling Pathways in Disease
- Alzheimer's disease research and treatments
- Marine Sponges and Natural Products
- Drug-Induced Hepatotoxicity and Protection
- Renal Diseases and Glomerulopathies
- Autoimmune Bullous Skin Diseases
- Advanced Glycation End Products research
Shanghai Clinical Research Center
2024
Affiliated Hospital of Southwest Medical University
2017-2024
Abstract Alzheimer’s disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translational modifications, especially acetylation, play significant role in it. With the development of mass spectrometry proteomics, an increasing number novel HPTMs, including lactoylation, crotonylation, β -hydroxybutyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation, been identified. These HPTMs closely link substance metabolism to gene regulation, relevant...
Isoliquiritigenin, a flavonoid found in licorice, has been considered as an antioxidive and hepato-protective agent. Recent studies have shown that possible mechanism for triptolide-induced hepatotoxicity is related to oxidative damage induced by reactive oxygen species. This study was done investigate the protection effect of isoliquiritigenin against involved. An acute liver injury model established intraperitoneal injection triptolide (1.0 mg · kg-1) mice. Different doses (12.5, 25 50...
The aim of this study was to assess the mechanism curcumin with chitosan nanoparticles in regulating activity podocytes diabetic nephropathy through alleviating oxidative stress and inflammation. MCP-5 cells were cultivated vitro after being randomly divided into four sets, including control set, high sugar set nanometer set. Proliferation detected apoptotic condition testing Caspase 3. activities malondialdehyde (MDA) superoxide dismutase (SOD) also detected, ROS content. Expressions TNF- α...