A5072015563- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Phytochemical compounds biological activities
- Alkaloids: synthesis and pharmacology
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Toxin Mechanisms and Immunotoxins
- Bioactive natural compounds
- Phytochemical Studies and Bioactivities
- Plant biochemistry and biosynthesis
- Berberine and alkaloids research
- Plant-derived Lignans Synthesis and Bioactivity
- Biological Activity of Diterpenoids and Biflavonoids
- Sesquiterpenes and Asteraceae Studies
- Cocoa and Sweet Potato Agronomy
- Polysaccharides and Plant Cell Walls
- Bioactive Compounds and Antitumor Agents
- Insect Pest Control Strategies
- Phytochemistry and Bioactivity Studies
- Chemical synthesis and alkaloids
- Phytochemistry and Bioactive Compounds
- Calcium signaling and nucleotide metabolism
- Synthesis of Organic Compounds
- Traditional Chinese Medicine Studies
Guilin Medical University
2015-2025
Kunming Institute of Botany
2008-2023
Chinese Academy of Sciences
2009-2023
Guangxi Normal University
2021
Guangxi Institute of Botany
2021
Affiliated Hospital of Guilin Medical College
2009
An unprecedented cage-like alkaloid, scholarisine A was isolated from the leaves of Alstonia scholaris and its structure determined on basis 1D 2D NMR, FTIR, UV, high-resolution mass spectroscopic data. This alkaloid might be derived picrinine via oxygenation, rearrangement, lactonization.
Previous findings suggested that a four-protein complex, including sterol-regulatory element-binding protein (SREBP), SREBP-cleavage-activating (SCAP), insulin-induced gene (INSIG) and progesterone receptor membrane component 1 (PGRMC1), within the endoplasmic reticulum appears to be an important regulator responsible for atypical antipsychotic drug (AAPD)-induced lipid disturbances. In present study, effects of typical AAPDs as well treatment outcome steroid antagonist mifepristone (MIF) on...
Wu‐Teng Decoction (WTD) is a significant in‐hospital preparation widely used in clinical practice to treat rheumatoid arthritis (RA) China, however, its active substances and underlying mechanisms remain unclear. In this study, the chemical constituents of WTD were analyzed using UHPLC‐MS/MS, identifying total 120 compounds, including flavonoids, phenylpropanoids, phenolic acids, alkaloids, etc. Subsequently, network pharmacology analyses revealed that 29 compounds potential for treatment...
Eight new monoterpenoid indole alkaloids, alstoyunines A−H (1−8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of the alkaloids established by means extensive spectroscopic methods. Alstoyunines C (3), E (5), and F (6) showed selective inhibition Cox-2 (>75%). Alstoyunine weak cytotoxicity against human myeloid leukemia HL-60 (IC50 = 3.89 μM) hepatocellular carcinoma SMMC-7721 21.73 cell lines.
Schizophrenia (SZ) is considered to be a multifactorial brain disorder with defects involving many biochemical pathways. Patients SZ show variable responses current pharmacological treatments of because the heterogeneity this disorder. Stress has significant role in pathophysiological pathways and therapeutic SZ. Atypical antipsychotic drugs (AAPDs) can modulate stress response hypothalamic–pituitary–adrenal (HPA) axis exert effects on by targeting prefrontal cortex (PFC) hippocampus. To...
Three new sterols (1−3) including an unprecedented ring A-seco natural product (1), five terpenoids (4−8), and 15 known compounds were isolated from the bark of Melia azedarach. Their structures elucidated by means spectroscopic data, structure 1 was confirmed X-ray crystallography.
Abstract Four new compounds named (3 E ,7 Z ,11 )‐19‐hydroxycasba‐3,7,11‐trien‐5‐one ( 1 ), 6 α ‐hydroxy‐10 β ‐methoxy‐7 ,8 ‐epoxy‐5‐oxocasbane‐20,10‐olide 2 15 ‐hydroxylup‐20(29)‐en‐3‐one 3 and (2 R ,4a , 8a )‐3,4,4a,8a‐tetrahydro‐4a‐hydroxy‐2,6,7,8a‐tetramethyl‐2‐(4,8,12‐trimethyltridecyl)‐2 H ‐chromene‐5,8‐dione 4 ) were isolated from the MeOH extracts of aerial parts Ricinus communis L. by chromatographic methods. Their structures elucidated extensive spectroscopic experiments.
Five dimeric Erythrina alkaloids, named erythrivarines J-N, were isolated from the barks of variegata L. (Fabaceae). The J-L featured a 6/6/5/6/6/5/6/6/6 ring system and super conjugated double bond systems, causing intense color blue to wine red, while M-N looked orange. structures compounds elucidated by 1D 2D NMR experiments combined with MS confirmed X-ray crystal diffraction technique. performed bioassay using HEI-OC-1 cells revealed neuroprotective properties erythrivarine N against...
Two new aporphine-type isoquinoline alkaloids, (+)-N-(methoxy-carbonyl)-N-norlauroscholtzine (1) and (+)-N-(methoxy-carbonyl)-N-norglaucine (2), were isolated from Litsea cubeba identified by spectroscopic techniques (NMR, MS, UV, IR). Their structures contain an N-(methoxycarbonyl) moiety, which has seldomly been found in the natural products of these analogs. Both compounds 1 2 showed no antibacterial activity against Staphylococcus aureus.
Six compounds, benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation compound 1 was discussed in detail based on its 2D-NMR data. Compound showed weak cytotoxicity against cell lines T-24, NCI-H460, HepG2, SMMC-7721, CNE, MDA-MB-231 B16F10 with inhibition rates 10.01% to 34.05%...
Two new abietane diterpene acids, pinyunins A (1) and B (2), a lignan, 2-[2-hydroxy-5-(3- hydroxypropyl)-3-methoxyphenyl]-1-(2,3-dihydroxyphenyl)propane-1,3-diol (3), eight known diterpenoids (4 - 11) were isolated from the bark of Pinus yunnanensis Franch. Their structures elucidated by spectroscopic methods. Compounds 1 3 exhibited high inhibitions on Cox-2 (> 80 %) low Cox-1 (< 50%), showing trend selective inhibition Cox-2, while positive controls NS-398 (Cox-2) SC-560 (Cox-1) gave...
One new long-chain ester derivative of trans-ferulic acid 1 and one natural tirucallane-type triterpenoid 2, together with forty known compounds (3-42), were isolated from the barks Melia azedarach. Their structures established on basis spectroscopic data interpretation. Compounds 7, 9, 10, 12, 13 showed significant inhibitory activities against PTP1B IC50 values 13.82 ± 1.29 μM, 13.29 2.26 20.27 0.52 24.36 1.25 15.23 0.6 respectively.
Seven terpenoids and three sterols were isolated from the methanol extracts of aerial parts Ricinus communis by chromatography methods their structures identified spectra analysis as ficusic acid( 1), phytol(2), callyspinol(3) , lupeol(4), 30-norlupan-3beta-ol-20-one(5) lup-20(29)-en-3beta,15alpha-diol(6) acetylaleuritolic 7), stigmast4-en-3-one(8) stig-mast-4-en-6beta-ol-3-one(9) stigmast4-en-3,6-dione(10). Compounds 1-3 5-10 obtained this species for first time 5 6 showed significant...
A new anti-inflammatory spirovetivane-type sesquiterpenoid, designated as 1,10-didehydrolubimin (1) and thirteen known compounds (2 - 14) were isolated from the whole plants of ‘Yi’ ethnomedicinal plant Incarvillea arguta. Their structures established based on spectral methods by comparison data with those reported previously. Compound 1 exhibited significant inhibitory effects Cox-1 Cox-2 a negative effect against 5-Lox at concentration 100 μM.
A new natural product, 3α,19-dihydroxyl-ent-pimara-8(14),15-diene (1), which possesses an α-orientation hydroxymethyl at C-4 and ∆8,14 groups, as well eight known compounds, was isolated from the rhizomes of Ricinus communis. The structure 1 elucidated by extensive spectroscopic methods its absolute configurations were confirmed X-ray crystallographic analysis. inhibitory rate against protein tyrosine phosphatase 1B (PTP1B) 49.49% concentration 6.58 × 10-5 mol/L.
The present study investigated the cytotoxic activities against MCF-7 and MDA-MB-231 cells, potential antioxidant α-glucosidase inhibitory of extracts aerial parts Trachelospermum jasminoides, a traditional medicinal plant used for treatment rheumatic arthralgia in China. In MTT assay microscopic analysis, ethyl acetate extract (EAE) T. jasminoides showed moderate effect with IC50 values 109.54 ± 2.39 μg/mL 162.68 9.52 μg/mL, respectively, but water (WE) was inactive both them. With gallic...