A5070997849- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Tryptophan and brain disorders
- Fatty Acid Research and Health
- Shoulder Injury and Treatment
- Schizophrenia research and treatment
- Musculoskeletal synovial abnormalities and treatments
- Diet and metabolism studies
- Stress Responses and Cortisol
- Peripheral Nerve Disorders
- Peroxisome Proliferator-Activated Receptors
- Bone fractures and treatments
- Surgical Sutures and Adhesives
- Cholesterol and Lipid Metabolism
- Medical Malpractice and Liability Issues
- Neuroscience and Neuropharmacology Research
- Tendon Structure and Treatment
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Lipid metabolism and biosynthesis
- Dupuytren's Contracture and Treatments
- Bipolar Disorder and Treatment
- Lysosomal Storage Disorders Research
- Eicosanoids and Hypertension Pharmacology
- Shoulder and Clavicle Injuries
Stanford University
2015-2024
Stanford Medicine
2015-2024
Chinese Academy of Sciences
2005-2024
Ningbo Institute of Industrial Technology
2024
Stanford Health Care
2014-2022
VA Pittsburgh Healthcare System
2011-2020
University of Pittsburgh
2011-2020
VA Healthcare-VISN 4
2020
Fukuoka University
2019
Palo Alto University
2013-2019
Altered antioxidant status has been reported in schizophrenia. The glutathione (GSH) redox system is important for reducing oxidative stress. GSH, a radical scavenger, converted to oxidized (GSSG) through peroxidase (GPx), and back GSH by reductase (GR). Measurements of GSSG its related enzymatic reactions are thus evaluating the status. In present study, levels GSSG, GPx GR were assessed caudate region postmortem brains from schizophrenic patients control subjects (with without other...
We measured the alcohol sugars in sural nerves from 11 controls, 21 conventionally treated patients with diabetes and neuropathy, 4 diabetics without neuropathy. The results were related to metabolic control clinical, neuropathological, morphometric abnormalities nerves. mean endoneurial glucose, fructose, sorbitol values higher diabetic than controls. Linear regression analysis revealed that nerve content was inversely number of myelinated fibers (P = 0.003). Mean levels myo-inositol not...
Recombinant, replication-deficient adenovirus (Ad) vectors have been successfully used to transfer and express the normal human cystic fibrosis transmembrane conductance regulator (CFTR) cDNA in vivo respiratory epithelium of experimental animals humans with (CF). Since Ad-directed gene expression wanes over time, repeat administration is necessary achieve an effective treatment for CF. A major hurdle such a strategy possibility that anti-Ad humoral immunity may prevent individuals...
There is a critical need for mapping early metabolic changes in schizophrenia to capture failures regulation of biochemical pathways and networks. This information could provide valuable insights about disease mechanisms, trajectory progression, diagnostic biomarkers. We used lipidomics platform measure individual lipid species 20 drug-naïve patients with first episode (FE group), chronic that had not adhered prescribed medications (RE 29 race-matched control subjects without schizophrenia....
METACHROMATIC leukodystrophy of the late infantile type, an autosomal recessive inherited disorder caused by a deficiency arylsulfatase A activity, is characterized progressive mental regression, loss speech, quadriparesis, peripheral neuropathy, and death within few years onset.1 We describe 10-year-old girl with metachromatic in whom neurophysiologic function sulfatide metabolism had improved after she received bone marrow transplant five before. These results may encourage use...
Alterations in antioxidant status schizophrenia suggest free radical-mediated neurotoxicity; this finding can be a consequence of increased radical production. There are multiple pathways to excess generation and subsequent oxidative stress. One such pathway is the formation peroxynitrite by reaction nitric oxide (NO) superoxide radical. NO formed from L-arginine synthase (NOS). A constitutive cytosolic isoform, neuronal NOS (nNOS), appears fairly stable postmortem brain tissues. Utilizing...
Background: The epicardial border zone (EBZ) of surviving myocytes in the healing, 4- to 5-day-old canine infarct is an arrhythmogenic substrate characterized by both structural and functional remodeling Cx43. Unknown whether gap junction conductance heterogeneous EBZ like that sarcolemmal ion channel how influences conduction anisotropy.
Endoneurial hypoxia has been suggested as a mechanism of human and experimental diabetic neuropathy (EDN). We found that rats rendered for 4 months had reduced nerve blood flow (NBF) oxygen tension (PnO2). The NBF was by at least 33% in EDN 60% the tensions endoneurial O2 histogram were less than 25 mm Hg (3.3 kPa) compared with only 19% controls. To test hypothesis may part be due to hypoxia, we studied effectiveness supplementation preventing some electrophysiologic biochemical...
The cardinal electrophysiological abnormalities in experimental diabetic (EDN) and galactose (EGN) neuropathy, models which endoneurial hypoxia has been demonstrated, are a slowing nerve conduction velocity (NCV) resistance to ischemic block (RICB). These also present human where microangiopathy demonstrated be more severe than EDN so that is likely present. We examined the effects of per se on normal nerves. In rats subjected chronic (10% O2) for up 10 wk, two had developed by 4 wk were...
Ordered crystalline 1D nanomaterial assemblies are prepared from an organic blue-light-emitting material, 1,2,3,4,5-pentaphenyl-1,3-cyclopentadiene (PPCP). The as-prepared PPCP nanostructures exhibit a novel multicolor emission property, that is, blue, green, and red can be achieved when irradiating the with different wavelengths.
One branch of the tryptophan catabolic cascade is kynurenine pathway, which produces neurotoxic [3-hydroxykynurenine (3-OHKY), quinolinic acid] and neuroinhibitory (kynurenic acid) compounds. Kynurenic acid acts as a competitive antagonist at glycine site N-methyl-d-asparate receptors high concentrations non-competitive on α7-nicotinic acetylcholine receptor low concentrations. Kynurenine compounds also influence cognitive functions known to be disrupted in schizophrenia. Alterations...