A5100373456- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Cholinesterase and Neurodegenerative Diseases
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- Chronic Disease Management Strategies
- Health disparities and outcomes
- Autophagy in Disease and Therapy
- Nanoparticle-Based Drug Delivery
- Global Health Care Issues
- Cancer, Lipids, and Metabolism
- Hydrogels: synthesis, properties, applications
- Epigenetics and DNA Methylation
- Insect and Pesticide Research
- Pancreatic function and diabetes
- Advanced Polymer Synthesis and Characterization
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
Rockefeller University
2020-2025
Peking University Shenzhen Hospital
2020-2025
Hong Kong University of Science and Technology
2020-2025
University of Hong Kong
2020-2025
Chongqing Medical University
2017-2025
Shenzhen Center for Disease Control and Prevention
2025
Sun Yat-sen University
2020-2024
University College London
2023
Shenyang Pharmaceutical University
2023
Capital Medical University
2020-2022
Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic functions. However, how mitochondria sense the abundance regulate metabolic homeostasis is not well understood. In this work, we focused on glutathione (GSH), a critical redox metabolite in mitochondria, identified feedback mechanism that controls its through mitochondrial GSH transporter, SLC25A39. Under physiological conditions, SLC25A39 rapidly degraded by protease AFG3L2. Depletion dissociates...
Emerging evidences have indicated that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of cancers. Dysregulation lncRNA MIR31HG has recently been reported several types cancers, researches on function cancers suggested could act as either oncogene or tumor suppressor. But functional involvement not studied hepatocellular carcinoma (HCC).In this study, MTS assays, colony formation assay, Wound-healing Transwell assy, xenografts experiments were used to...
Worldwide, over a billion people suffer from chronic liver diseases, which often lead to fibrosis and then cirrhosis. Treatments for remain experimental, in part because no unifying mechanism has been identified that initiates fibrosis. Necroptosis implicated multiple diseases. Here, we report O-linked β-N-acetylglucosamine (O-GlcNAc) modification protects against hepatocyte necroptosis initiation of Decreased O-GlcNAc levels were seen patients with alcoholic cirrhosis mice ethanol-induced...
Abstract Excessive visceral fat accumulation is a primary risk factor for metabolically unhealthy obesity and related diseases. The highly susceptible to the availability of external nutrients. Nutrient flux into hexosamine biosynthetic pathway leads protein posttranslational modification by O -linked β-N-acetylglucosamine ( -GlcNAc) moieties. -GlcNAc transferase (OGT) responsible addition GlcNAc moieties target proteins. Here, we report that inducible deletion adipose OGT causes rapid loss...
// Liying Zhu 1, 3, * , Nenghong Yang 4, Juan Chen 1 Tao Zeng Shaoying Yan Yuyang Liu Gangfeng Yu Qiuxu Guiqin Du 3 Wei Pan Xing Li Huihao Zhou Ailong Huang 2 and Hua Tang Key Laboratory of Molecular Biology for Infectious Diseases (Ministry Education), Institute Viral Hepatitis, Department Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Collaborative Innovation Center Diagnosis Treatment Zhejiang Hangzhou, Laboratory, Guizhou Guiyang, 4 Hepatobiliary...
Background/Aims: The long-noncoding RNA colorectal neoplasia differentially expressed (CRNDE) gene was first found to be activated in neoplasia. Now, it also has been upregulated many other solid tumors. Whether CRNDE affects tumorigenesis remains unknown. Methods: We conducted bioinformatics, real-time polymerase chain reaction (PCR), Western blot analysis, cell proliferation assay, colony formation wound healing migration and invasion assays, immunoprecipitation, reporter vector...
Autism spectrum disorder (ASD) and dyslexia are both neurodevelopmental disorders with high prevalence in children. Both have strong genetic basis, share similar social communication deficits co-occurring impairments of reading or language. However, whether these two common risks remain elusive. DOCK4 (dedicator for cytokinesis 4), a guanine nucleotide exchange factor (GEF) the small GTPase Rac1, is one few genes that associated ASD dyslexia. Dock4 important neuronal development behaviors....
Abstract Early noninvasive screening and regression therapy for vulnerable atherosclerotic plaques remain challenging. In this study, it is aimed to develop a new approach the active targeting of with nano‐agents aid imaging treatment. Biocompatible hyaluronic acid (HA)‐guided cerasomes are generated selectively target CD44‐positive cells within plaque in vitro studies vivo testing Apoe −/− mice. Rosuvastatin (RST) encapsulated HA‐guided cerasome nano‐formulation produce HA‐CC‐RST, which...
Abstract Background Brain metastasis (BM) is thought to be related the mortality and poor prognosis of non-small cell lung cancer (NSCLC). Despite promising development NSCLC treatment, treatment BM still not optimistic due existence blood-brain barrier (BBB) that prevent drug penetration, as well short median survival time patients left for treatment. In this context, further quick effective pre-clinical models needed in Here, we report a model system using zebrafish promote drugs with BM....
Abstract Background Chemotherapy is widely used to treat hepatocellular carcinoma (HCC). Although sorafenib (SO) the only chemotherapy drug approved by FDA for treatment of HCC, it associated with several disadvantages including low water solubility, bioavailability, lack targeting and easily causes systemic toxicity. In recent years, nanocarriers have shown promise in delivery effectively solve these problems. Herein, we SO-loaded overcome defects during HCC. Specifically, encapsulated...
Indole works as an interspecies signal molecule to regulate multiple physiological activities, like antibiotic resistance, acid and virulence. However, the effect of indole on conjugation is unknown. Here, with Escherichia coli SM10 λπ a donor strain that carries chromosomally integrated conjugative RP4 plasmid, we explored mobilizable pUCP24T plasmid imparting gentamycin resistance. The results showed exogenous treatment inhibited transfer from recipient strains, Pseudomonas aeruginosa PAO1...
Diabetes management permeates patients' daily routines and interacts with their living context. Less is known about how older Chinese couples view supportive roles the allocation of responsibility between them.To explore dyadic appraisal, coping barriers to diabetes shared by couples.A qualitative study where at least one partner had type 2 mellitus was implemented in four communities Guangzhou, China. Four focus groups containing 11 couples, ten in-depth interviews individual were conducted...