A5015151349- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Proteomics Techniques and Applications
- Hepatitis B Virus Studies
- RNA Research and Splicing
- Mechanisms of cancer metastasis
- Hepatocellular Carcinoma Treatment and Prognosis
- Biosensors and Analytical Detection
- Inflammatory Biomarkers in Disease Prognosis
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer Mechanisms and Therapy
- Protein Kinase Regulation and GTPase Signaling
- Cancer, Lipids, and Metabolism
- Uterine Myomas and Treatments
- PI3K/AKT/mTOR signaling in cancer
Chongqing Medical University
2017-2025
Nanchang University
2022-2024
First Affiliated Hospital of Jiangxi Medical College
2024
First Affiliated Hospital of Nanchang University
2022-2024
Guiyang Medical University
2016
Huzhou Central Hospital
2009
Emerging evidences have indicated that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of cancers. Dysregulation lncRNA MIR31HG has recently been reported several types cancers, researches on function cancers suggested could act as either oncogene or tumor suppressor. But functional involvement not studied hepatocellular carcinoma (HCC).In this study, MTS assays, colony formation assay, Wound-healing Transwell assy, xenografts experiments were used to...
// Liying Zhu 1, 3, * , Nenghong Yang 4, Juan Chen 1 Tao Zeng Shaoying Yan Yuyang Liu Gangfeng Yu Qiuxu Guiqin Du 3 Wei Pan Xing Li Huihao Zhou Ailong Huang 2 and Hua Tang Key Laboratory of Molecular Biology for Infectious Diseases (Ministry Education), Institute Viral Hepatitis, Department Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Collaborative Innovation Center Diagnosis Treatment Zhejiang Hangzhou, Laboratory, Guizhou Guiyang, 4 Hepatobiliary...
Background/Aims: The long-noncoding RNA colorectal neoplasia differentially expressed (CRNDE) gene was first found to be activated in neoplasia. Now, it also has been upregulated many other solid tumors. Whether CRNDE affects tumorigenesis remains unknown. Methods: We conducted bioinformatics, real-time polymerase chain reaction (PCR), Western blot analysis, cell proliferation assay, colony formation wound healing migration and invasion assays, immunoprecipitation, reporter vector...
Protein-stabilized gold nanoclusters (Prot-Au NCs) have been widely used in biosensing and cell imaging owing to their excellent optical properties low biotoxicity. However, several Prot-Au NCs reported the literature do not retain biological role of protein, which greatly limits ability directly detect biomarkers. This study demonstrated for first time successful synthesis dual-function avidin-stabilized (Av-Au using a one-pot method. The resulting Av-Au exhibited intense blue red emissions...
Abstract Hepatitis B virus‐related hepatocellular carcinoma (HBV‐related HCC) is a common, highly invasive malignant tumor associated with high mortality rate. This study aimed to identify the effective diagnostic and prognostic biomarkers for HBV‐related HCC. With HCC RNA‐sequencing data of The Cancer Genome Atlas (TCGA) database, 159 differentially expressed long noncoding RNAs (lncRNAs) between para‐carcinoma normal samples were identified, 12 lncRNAs eventually assessed deeper research....
Polyacrylamide gel (PAG) is extensively used as a matrix for biomolecular analysis and fractionation. However, the traditional polymerization catalyst system N,N,N',N'-tetramethylethylenediamine (TEMED)/ammonium persulphate (APS) of PAG presents non-negligible toxicity. Herein, we utilized green efficient bio-enzyme horseradish peroxidase (HRP) to catalyze polyacrylamide. At same time, efficacy this in separating nucleic acids proteins was confirmed by applying electrophoresis. This study...
Abstract Background Inherent limitations of single cancer therapy are overcome by multi-therapy modality, which integrates characteristics each therapeutic modality and material chemistry. The multi-modal method has the potential for becoming one next generation options treatments. Photothermal (PTT) is an efficient, non-invasive treatment that can be used on various types. We propose acid-triggered self-destructing nano-biocatalyst integrated starvation/chemical/photothermal triple based...
Platelet distribution width (PDW) is a marker of platelet anisocytosis that increases with activation. The clinical implications PDW in HCC are not well-defined. This study aimed to determine whether could predict recurrence patients after resection.Between January and December 2008, 471 were recruited retrospectively. clinicopathological characteristics analyzed based on the relationship between two groups. Kaplan-Meier curves multivariate Cox regression analyses used evaluate disease-free...
Abstract Background For people with advanced hepatocellular carcinoma (HCC), systemic chemotherapy remains the only choice of palliative treatment. However, efficacy is not effective due to its short blood circulation times, nonspecific cell and tissue biodistribution, rapid metabolism or excretion from body. Therefore, a targeted nanomedicine delivery system urgently needed. Methods In order improve treatment efficiency HCC, based on in situ growth copper metal organic framework mesoporous...
Accumulated evidence revealed that numerous long noncoding RNAs (lncRNAs) have been found to be involved in the development and progression of hepatocellular carcinoma (HCC). LINC00628, a member lncRNAs, has reported act as tumor suppressor gastric cancer breast cancer. However, its potential role HCC still remains unknown. Herein, we characterized function LINC00628 HCC. Our investigation were dramatically decreased tissues cells, inhibited migration invasion cells vitro vivo. Moreover,...
Objective To studythe effects of prolacfin(PRL)on uterineleiomyoma and the relationship between prolactin prolaetin receptor(PRL-R).Methods Thirty patients with uterine leiomyoma as observed group thirty hydrosalpinx or pyosalpingitis a8 control were studied.Serum prolaetin(PrL),estradiol(E2)and progesterone(P)level determinted by radioimmunoassay before,during three months after hysterectomy in before salpingectomy group.Results Serum levd was signifieantly higher than that...