A5023475645- MicroRNA in disease regulation
- Blood Pressure and Hypertension Studies
- RNA regulation and disease
- Migraine and Headache Studies
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Nutritional Studies and Diet
- Stochastic Gradient Optimization Techniques
- IoT and Edge/Fog Computing
- Stress Responses and Cortisol
- Advanced Text Analysis Techniques
- Cryptography and Data Security
- TGF-β signaling in diseases
- Birth, Development, and Health
- Privacy-Preserving Technologies in Data
- Nuclear Receptors and Signaling
- Misinformation and Its Impacts
- Heart rate and cardiovascular health
- Sodium Intake and Health
- Meningioma and schwannoma management
- Gastroesophageal reflux and treatments
- Heart Rate Variability and Autonomic Control
Zhongnan Hospital of Wuhan University
2019-2025
Wuhan University
2019-2025
Hebei University
2010-2025
Vanke (China)
2025
Tsinghua University
2025
Chinese PLA General Hospital
2012-2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As mimicking fasting, it triggers the production of ketone bodies (KBs) brings body into state ketosis. Recent accumulating studies on humans animal models have shown that KD beneficial to neurodegenerative diseases through modulating central peripheral metabolism, mitochondrial function, inflammation, oxidative stress, autophagy, gut microbiome. Complicated interplay microbiome, other mechanisms can regulate...
Dietary risk has always been a major factor for colorectal cancer (CRC). However, the contribution of dietary factors to CRC at level region, gender, and age not fully characterized. Based on Global Burden Disease (GBD) 2019 study, death rates, age-standardized mortality rates (ASDRs), estimated annual percentage changes (EAPCs) were calculated assess trends attributable over past 30 years. Globally, cases increased 1,085,797 in 2019, number deaths attributed 365,752 representing...
Abstract Immune checkpoint inhibitors (ICIs) have limited clinical efficacy against gastric cancer (GC) due to the nonimmunogenic tumor microenvironment. Therefore, inducing immunogenic cell death (ICD) reprogram landscape is essential. This study develops HD‐FA nanoparticles by encapsulating a novel mitochondrion‐targeted NIR‐II modulator, HD, within DSPE‐PEG‐FA. exhibits superior spatiotemporal resolution, robust accumulation, and minimal adverse effects. Upon 808 nm laser irradiation,...
Abstract Background Osteosarcoma (OS) is the most frequent cancer derived from bone, and prognosis of OS poor. Metabolic alterations have been previously reported to contribute development OS, arsenic compounds suggested exhibit strong anti-OS effects. However, few studies described therapeutic efficiency by targeting metabolism in OS. Methods Here, we presented a novel organo-arsenic compound, Aa-Z2, its antitumour efficacy against both vitro vivo. Results Aa-Z2 induced cell apoptosis, G2/M...
Radiotherapy is used to treat gastric cancer (GC); however, radioresistance challenges the clinical outcomes of GC, and mechanisms in GC remain poorly understood. Here, we report that TGF-β receptor inhibitor, LY2109761 (LY), a potential radiosensitizer both vitro vivo. As per Cancer Genome Atlas database, overexpression significantly related poor overall survival patients. We demonstrated TGF-β/SMAD4 signaling pathway was activated radioresistant cells LY can enhance activities irradiation...
Prenatal stress can result in various behavior deficits offspring. Here we tested the effects of environmental enrichment during gestation used as a preventive strategy on prenatal-stressed offspring rats well underlying structure basis. We compared effect size to that after weaning. Our results showed partially prevented anxiety and damage learning memory evaluated by elevated plus-maze test Morris water maze test. At same time, inhibited decrease spine density CA1 dentate gyrus neurons...
To investigate the impact of human papillomavirus (HPV) status on head and neck squamous cell carcinoma (HNSCC) arising from different anatomic subsites.HNSCC patients with known HPV Surveillance, Epidemiology, End Results (SEER) database between 2010-2015 were included in our analysis. Patients classified into three categories HNSCC according to Site recode ICD-O-3/WHO 2008 Primary Site-labeled, namely, oropharynx, hypopharynx, nasopharynx. Logistic regression model was conducted evaluate...
Parkinson's disease (PD) is a common neurodegenerative disease, and the mechanism underlying PD pathogenesis not completely understood. Increasing evidence indicates that microRNAs (miRNAs) play critical regulatory role in of PD. This study aimed to explore miRNA-mRNA network for The differentially expressed miRNAs (DEmis) genes (DEGs) between patients healthy donors were screened from miRNA dataset GSE16658 mRNA GSE100054 downloaded Gene Expression Omnibus (GEO) database. Target DEmis...
Objective Previous studies have shown that an elevated heart rate is associated with a higher risk of cardiovascular events. This study aimed to prospectively examine the relationship between resting (RHR) and all-cause mortality in Chinese patients hypertension. Design An observational, prospective population-based cohort study. Setting The Kailuan was conducted Tangshan City northern China. Participants We enrolled 46 561 who did not receive beta-blocker treatment were diagnosed...
Background: The pes anserinus was an important graft choice for anterior cruciate ligament (ACL) reconstruction. infrapatellar branch of the saphenous nerve (IPBSN) might be damaged in this surgery. This study aimed to provide anatomic and ultrasonic measurement data superficial nerves. Methods: Eighty lower limb specimens forty adult cadavers were dissected. length, width, thickness, position tibial attachment tendons anthropometric measured, as well distance between anserinus. Sixty...
The adverse effects of early-life tobacco smoke exposure on chronic kidney disease (CKD) risk remain unclear. This study aimed to investigate the associations with CKD incidence in adulthood, and further explore modification physical activity (PA).
Abstract Background The association between dietary sodium intake and blood pressure variability (BPV) in hypertensive patients remains unclear. objective of this study was to demonstrate whether is a predictor elevated BPV Chinese with hypertension. Methods A total 235 essential hypertension were enrolled the Department Cardiology, People's Liberation Army (PLA) General Hospital 2018 2019, all whom underwent 24-h ambulatory monitoring. calculated as standard deviation (SD), coefficient...