A5052064258- Genetics, Aging, and Longevity in Model Organisms
- Digestive system and related health
- Medical Imaging Techniques and Applications
- Pluripotent Stem Cells Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Teacher Professional Development and Motivation
- Dysphagia Assessment and Management
- Teacher Education and Leadership Studies
- Gut microbiota and health
- Team Dynamics and Performance
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Education and Technology Integration
- Religion, Society, and Development
- Chronic Myeloid Leukemia Treatments
- Trauma Management and Diagnosis
- Religion and Sociopolitical Dynamics in Nigeria
- Case Reports on Hematomas
- Cognitive Functions and Memory
- Memory Processes and Influences
- Traumatic Brain Injury and Neurovascular Disturbances
- Health, Environment, Cognitive Aging
- Chromatin Remodeling and Cancer
- Online and Blended Learning
- Educational Strategies and Epistemologies
Colorado State University
1972-2023
Landon Pediatric Foundation
2023
Rockefeller University
2020-2022
Lung Institute
2018
University of North Carolina at Chapel Hill
2018
Dana-Farber Cancer Institute
2016
Wake Forest University
2001-2009
St. Thomas Hospital
2007
Tempe Union High School District
2002
Case Western Reserve University
1992
Clearance of intrapulmonary mucus by the high-velocity airflow generated cough is major rescue clearance mechanism in subjects with mucoobstructive diseases and failed cilial-dependent clearance, e.g., cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD). Previous studies have investigated mechanical forces at airway surfaces but not considered effects biophysical properties on efficacy. Theoretically, can be cleared from lung an adhesive failure, i.e., breaking mucus-cell...
Analytical expressions for the local light yield as a function of deposited energy (−dE/dx) and total scintillation integrated over track an electron initial E are derived from radiative and/or nonradiative rates first through third order in density electronic excitations. The model is formulated terms rate constants, some which can be determined independently time-resolved spectroscopy others estimated measured efficiency constraint assumed to apply each kinetic order. parameters used...
The purpose of this investigation is to determine the normal values for regional cerebral blood flow (rCBF) as determined by xenon inhalation method Obrist. Normal all rCBF parameters were measured in 15 healthy individuals. Our data are compared with obtained other investigators. In addition, test-retest measurements performed reproducibility method. results show that highly reproducible when carried out serial studies over a short period time.
We have studied the prevalence of an underlying myeloproliferative state in 20 patients with either hepatic or portal vein thrombosis. Using conventional clinical and laboratory criteria, was identified as cause thrombosis five (25%). A further 10 remaining 15 cases were found to characteristic vitro bone marrow culture studies cytogenetic abnormalities suggestive disorder. Although none these developed overt features such a disorder after median observation period two years, presence clonal...
Plasma thiamine concentrations affect l -asparaginase sensitivity of leukemia cells deficient for uptake.
ELT-2 is the major transcription factor (TF) required for Caenorhabditis elegans intestinal development. expression initiates in embryos to promote development and then persists after hatching through larval adult stages. Though sites of binding are characterized transcriptional changes that result from depletion known, an intestine-specific transcriptome profile spanning developmental time has been missing. We generated this dataset by performing Fluorescence Activated Cell Sorting on...
Operation of a high resolution compact clinical PET Scanner (PEM Flex/spl trade/) device as breast scanner is described. The features spatial (1.5 mm FWHM intrinsic resolution) result small crystals and position-sensitive photomultipliers. compactness the system allows it to reside within stereotactic X-ray mammography unit, or separate standalone capable compression. gamma rays are detected for volumetric reconstruction by two heads, each which contains 2,028 2 10 lutetium-containing...
mRNA localization and transport are integral in regulating gene expression. In Caenorhabditis elegans embryos, the maternally inherited erm-1 (Ezrin/Radixin/Moesin) becomes concentrated anterior blastomeres. localizes within those blastomeres to plasma membrane where essential ERM-1 protein, a membrane-actin linker, is also found. We demonstrate that of translation dependent requires its encoded N-terminal, membrane-binding (FERM) domain. By perturbing through multiple methods, we found at...
In this article the authors describe and illustrate two statistical techniques for measuring interviewer question objectivity. They conclude report with some suggestions achieving a more professional approach to objective questioning.
This article reports on some research about human motivation, and suggests applications to teachers. The author assumes that teachers are not much different from people in other occupations with respect motivation job satisfaction, administrators can improve their effectiveness by understanding applying the findings.
This protocol details the steps necessary to scale-up and synchronize C. elegans cultures for FACS isolation of embryonic cells, expressing germ layer nuclear markers. We cultured worms with agar-based NGM plates reduce any confounding effects that may be introduced by large scale liquid culture. utilizes one round mixed-stage culture growth followed synchronized growth. After synchronization, this provides conditions cells.
This protocol is for generating a single cell suspension suitable isolation of germ-layer-specific cells through Fluorescence Activated Cell Sorting (FACS) from embryo stage C. elegans. utilizes treatment with Chitinase and Pronase E to disrupt the cuticle. Embryos are mechanically homogenized 21G syringe needle.
The present study involved analyses of a Caucasian American sample ( n =949) and Japanese =400) for factors supporting Genetic Similarity Theory (GST). found no evidence the presence genetic similarity between spouses in either blood group nine loci. All results indicated random mating genes. did not provide consistent substantial support to show that spousal is correlated with degree component trait set seventeen individual differences variables, only yielding significant correlations this...
This protocol is for generating a single cell suspension suitable isolation of intestine-specific cells through Fluorescence Activated Cell Sorting (FACS) from L3 stage C. elegans. utilizes treatment with SDS-DTT solution and Pronase E to disrupt the cuticle. Worms are mechanically homogenized dounce homogenizer.
ABSTRACT Stress-adaptive mechanisms enable tumor cells to overcome metabolic constraints in nutrient and oxygen poor tumors. Aspartate is an endogenous limitation under hypoxic conditions, but the nature of adaptive that contribute aspartate availability growth are poorly understood. Here, using a combination metabolomics CRISPR-based genetic screens, we identify GOT2-catalyzed mitochondrial synthesis as essential dependency for proliferation pancreatic culture conditions. In contrast,...