A5010229998- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Bone health and treatments
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Parathyroid Disorders and Treatments
- Trace Elements in Health
- Venous Thromboembolism Diagnosis and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Renal and Vascular Pathologies
- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Glioma Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Intensive Care Unit Cognitive Disorders
- Cardiac tumors and thrombi
Intermountain Healthcare
2022-2025
University of Portsmouth
2024
Drug Safety Research Unit
2024
University of Utah
2014-2023
Huntsman Cancer Institute
2012-2023
University of Pittsburgh Medical Center
2022
Johns Hopkins University
2014-2018
Kennedy Krieger Institute
2018
Children's Hospital of Philadelphia
2018
University of Pennsylvania
2018
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been developed and established as an emerging technique in the generation of quantitative images metal distributions thin tissue sections brain samples (such human, rat mouse brain), with applications research related to neurodegenerative disorders. A new analytical protocol is described which includes sample preparation by cryo-cutting matrix-matched laboratory standards, spectrometric measurements, data...
During the COVID-19 pandemic, EMA set-up a large-scale cohort event monitoring (CEM) system to estimate incidence rates of patient-reported adverse drug reactions (ADRs) different vaccines across participating countries. This study aims give an up date and in-depth analysis frequency ADRs after 1st, 2nd, booster vaccination, identify potential predictors in developing describe time-to-onset (TTO) time-to-recovery (TTR) ADRs. A CEM was rolled out period ranging from February 2021 2023...
The purpose of this study was to compare optimized whole-body (WB) and dedicated high-resolution contrast-enhanced PET/CT protocols contrast enhanced CT in the preoperative staging primary squamous cell carcinoma head neck. <b>Methods:</b> A total 44 patients with clinically M0 neck underwent tumor resection dissection within 6 wk diagnostic imaging. Imaging consisted a standard WB protocol without intravenous enhancement, followed by (HN) protocol, which included diagnostic-quality (CECT)....
With the increasing application of F-18-fluorodeoxyglucose (FDG) positron emission imaging, there has been an evolving appreciation for range normal variants and realization that false-positives can lead to serious consequences.One most common causes a false-positive study is uptake FDG in areas hypermetabolic brown adipose tissue (HBAT). Areas involvement are often spatially closely related important lymph node groups neck, axilla, upper mediastinum, making critical differentiation...
F-FDG PET has been used for vascular disease, but its role in deep vein thrombosis (DVT) remains prospectively unexplored.Whole-body PET/CT scans were performed patients 1 to 10 weeks after onset of symptomatic DVT (n = 12) and control subjects without 24). The metabolic activity (SUVmax) thrombosed contralateral nonthrombosed segments was determined. sensitivity specificity the diagnosis determined by receiver operating characteristic curve analyses. In 2 with DVT, changes serial scans.The...
The objective was to compare F-fluorodeoxyglucose (FDG) and F-fluorothymidine (FLT) PET in differentiating radiation necrosis from recurrent glioma.Visual quantitative analyses were derived static FDG dynamic FLT 15 patients with suspected recurrence of treated grade 2 glioma or worse a new focus Gd contrast enhancement on MRI. For PET, SUVmax the ratio lesion SUVmean contralateral white matter measured. Patlak-derived metabolic flux parameter Kimax measured for same locus. A 5-point visual...
Using high-throughput analyses and the TRANSFAC database, we characterized TF signatures of head neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis target gene expression, correcting for effects DNA methylation copy number. this discovery pipeline, determined that human papillomavirus-related (HPV+) HPV- HNSCC differed significantly based on activity levels key TFs including AP1, STATs, NF-κB p53. Immunohistochemical confirmed is co-activated STAT3 pathways functional...
PET/CT with
In all pivotal trials of COVID-19 vaccines, the history previous SARS-CoV-2 infection was mentioned as one main exclusion criteria. absence clinical trials, observational studies are primary source for evidence generation. This study aims to describe patient-reported adverse drug reactions (ADRs) following first vaccination cycle, well administration booster doses different vaccine brands, in people with prior infection, compared infection-free matched cohorts vaccinees. A web-based...
86 Background: Prostate cancer often expresses prostate-specific membrane antigen (PSMA), which serves as a diagnostic and therapeutic target. Lutetium-177 ( 177 Lu)-PSMA-617 is radioligand therapy that delivers beta-particle radiation to PSMA-expressing sites. The prognostic implications of in-field progression (IFP) following prior treatment (RT) on Lu-PSMA-617 response in metastatic castration-resistant prostate (mCRPC) are unknown. Methods: We retrospectively reviewed our experience with...
Copper may play an important role in the brain aging and neurodegenerative diseases. We compare active Cu uptake, Cu-containing enzyme levels, total distribution brains of young mice. 67Cu was administered intravenously to 2, 7-9, 14 month old Active uptake measured at 24 h by digital phosphorautoradiography. Cerebral superoxide dismutase-1 (SOD-1) cytochrome-C oxidase subunit-1 (CCO-1) levels were analyzed immunohistochemistry. The section determined imaging laser ablation inductively...
Cancer survivors often relapse due to evolving drug-resistant clones and repopulating tumor stem cells. Our preclinical study demonstrated that terminal cancer patient's lymphocytes can be converted from tolerant bystanders in vivo into effective cytotoxic T-lymphocytes vitro killing own cells containing We designed a clinical trial combining peginterferon α-2b with imatinib for treatment of stage III/IV gastrointestinal stromal (GIST) the rational serves as danger signals promote antitumor...
Metastatic renal cell carcinoma has a poor prognosis and an intrinsic resistance to standard treatment. Sunitinib is oral receptor tyrosine kinase inhibitor that been used as first-line targeted therapy in metastatic carcinoma. While computed tomography (CT) currently the gold for response assessment oncological trials, numerous studies have shown positron emission (PET) imaging can provide information predictive of tumor treatment earlier than typical interval care follow-up CT imaging. In...
The safety profile of COVID-19 vaccines in immunocompromised patients has not been comprehensively evaluated.