A5011284240- Metabolism and Genetic Disorders
- Lipid Membrane Structure and Behavior
- Receptor Mechanisms and Signaling
- Endoplasmic Reticulum Stress and Disease
- Biochemical effects in animals
- Peroxisome Proliferator-Activated Receptors
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Muscle metabolism and nutrition
- Retinoids in leukemia and cellular processes
- Protein Kinase Regulation and GTPase Signaling
- Lipid metabolism and biosynthesis
- RNA Research and Splicing
- Sphingolipid Metabolism and Signaling
- Metabolomics and Mass Spectrometry Studies
- Nutrition, Genetics, and Disease
- ATP Synthase and ATPases Research
- Insect Utilization and Effects
- Pancreatic function and diabetes
- Atrial Fibrillation Management and Outcomes
- Amino Acid Enzymes and Metabolism
Memorial Sloan Kettering Cancer Center
2022-2024
Cornell University
2023-2024
Pusan National University
2014
Korea University
2011
Class A G protein-coupled receptors (GPCRs), a superfamily of cell membrane signaling receptors, moonlight as constitutively active phospholipid scramblases. The plasma metazoan cells is replete with GPCRs yet has strong resting trans-bilayer asymmetry, the lipid phosphatidylserine confined to cytoplasmic leaflet. To account for persistence this asymmetry in presence GPCR scramblases, we hypothesized that GPCR-mediated scrambling regulated by cholesterol, major constituent membrane. We now...
Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids in mammalian cells, are synthesized
This study was carried out to evaluate the relationship between threonine (Thr) efficiency and Thr dehydrogenase (TDG) activity as an indicator of oxidation on chicks fed with levels diets (CP [17.5% 21.5%] [3.8 4.7 g/100 g CP]; glycine [Gly][0.64% 0.98%] true digestible [dThr] [0.45% 0.60%]). Calculation based N-balance data exponential N-utilization model, TDG determined accumulation aminoacetone Gly during incubation hepatic mitochondria. found that in liver who received a diet containing...
This study was conducted to assess the relation between threonine (Thr) oxidation rate and efficiency on rat chicken fed with graded levels of protein threonine.The increase in content from 0.28 0.72% a diet containing 12.0% crude (CP) caused gradual dehydrogenase (TDG) activity liver.Similar, but more pronounced results were observed after 18.0% CP diet.Both combination highest level supplementation increased liver TDG significantly, indicating enhanced catabolism.Parameters utilization...
ABSTRACT Genome-wide association studies (GWAS) of serum metabolites have the potential to uncover genes that influence human metabolism. Here, we combined an integrative genetic analysis associating membrane transporters with a coessentiality map metabolic genes. This revealed connection between feline leukemia virus subgroup C cellular receptor 1 (FLVCR1) - plasma protein and phosphocholine, downstream metabolite choline Loss FLVCR1 in cells mice strongly impairs metabolism due block...
ABSTRACT Class A G protein-coupled receptors (GPCRs), a superfamily of cell membrane signaling receptors, moonlight as constitutively active phospholipid scramblases. The plasma metazoan cells is replete with GPCRs, yet has strong resting trans-bilayer asymmetry, the lipid phosphatidylserine confined to cytoplasmic leaflet. To account for persistence this asymmetry in presence GPCR scramblases, we hypothesized that GPCR-mediated scrambling regulated by cholesterol, major constituent...