About
Contact & Profiles
A5101513740
Research Areas
- Metalloenzymes and iron-sulfur proteins
- Sulfur Compounds in Biology
- Amino Acid Enzymes and Metabolism
Rockefeller University
2023
Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic functions. However, how mitochondria sense the abundance regulate metabolic homeostasis is not well understood. In this work, we focused on glutathione (GSH), a critical redox metabolite in mitochondria, identified feedback mechanism that controls its through mitochondrial GSH transporter, SLC25A39. Under physiological conditions, SLC25A39 rapidly degraded by protease AFG3L2. Depletion dissociates...
10.1126/science.adf4154
article
EN
Science
2023-11-02
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