A5088340525- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Platelet Disorders and Treatments
- Protein Degradation and Inhibitors
- Cancer Cells and Metastasis
- Fatty Acid Research and Health
- Endometriosis Research and Treatment
- Chronic Myeloid Leukemia Treatments
- Reproductive System and Pregnancy
- Neuroscience and Neural Engineering
- Hematopoietic Stem Cell Transplantation
- Psoriasis: Treatment and Pathogenesis
- Remote Sensing in Agriculture
- Prenatal Screening and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Genetics, Aging, and Longevity in Model Organisms
- T-cell and Retrovirus Studies
- Multiple Myeloma Research and Treatments
- Fibroblast Growth Factor Research
- CRISPR and Genetic Engineering
Binzhou University
2011-2025
Binzhou Medical University
2008-2025
Institute of Atmospheric Physics
2021
Chinese Academy of Sciences
2010-2021
Neural stem cells (NSCs) have great potentials in the application of neurodegenerative disease therapy, drug screening, and modeling. However, current approaches for induced NSCs (iNSCs) generation from somatic are still slow inefficient. Here we establish a rapid efficient method iNSCs human mouse fibroblasts by single microRNAs (miR-302a). These exhibited morphological, molecular functional properties resembling those adult NSCs, can be expanded more than 20 passages vitro. Furthermore,...
Mesenchymal stem cells (MSCs) possess reparative and immunoregulatory properties, representing a hope for cell‑based treatments. However, the mechanisms by which transplanted MSCs affect T helper (Th)17/regulatory cell (Treg) balance in asthma patients remain unclear. The aim of present study was to assess therapeutic effects human placenta (hPMSCs) asthma, explore underlying mechanisms; addition, impact hPMSCs transplantation on Th17/Treg lymph serum samples from asthmatic animals...
Neurogenic locus notch homolog protein (Notch) signaling mediates intracellular communication and may regulate cell fate decisions, including proliferation, differentiation, apoptosis. Mesenchymal stem cells (MSCs) possess immunomodulatory properties the potential for use in replacement treatments. The aim of present study was to evaluate therapeutic effects human placenta‑deviated MSCs (hPMSCs) asthma investigate mechanisms Notch mediated by transplanted MSCs. A Sprague‑Dawley rat ovalbumin...
ABSTRACT Neural stem cells play a vital role in maintaining tissue stability and extending lifespan. Transplanting these to treat neurodegenerative diseases faces challenges like cellular aging, low viability, immune rejection. We have effectively reprogrammed human fibroblasts into induced neural (iNSCs) via single-factor miR-302a strategy, which converted skin human-induced (hiNSCs) within 2-3 days. These showed delayed aging increased resistance oxidative stress compared wild-type cells....
Abstract Background: Neural stem cells (NSC) are essential for maintaining tissue homeostasis and promoting longevity in living organisms. As a promising approach to treating neurodegenerative diseases, NSC transplantation has been hampered by crucial issues such as cellular senescence, immune rejection, low cell viability. Methods: MiR-302a was used reprogram human mouse fibroblast into induced neural (iNSCs). In vitro, differentiation experiments were performed demonstrate that iNSCs have...
Neural stem cells (NSCs) have great potential in the application of neurodegenerative disease therapy, drug screening and modeling. NSC can be generated by reprogramming from terminally differentiated with transcription factors or small molecules. However, current methods for producing NSCs involve danger integrating foreign genes into genome problem low efficiency. Here, we report an efficient method to generate human skin-derived fibroblasts microRNA (mir-302a) 2-3 days. The induced...