A5101621202- Carbohydrate Chemistry and Synthesis
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Axial and Atropisomeric Chirality Synthesis
- Microbial Natural Products and Biosynthesis
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Molecular spectroscopy and chirality
- Synthetic Organic Chemistry Methods
- interferon and immune responses
- Spectroscopy and Chemometric Analyses
- T-cell and B-cell Immunology
- Chemical Synthesis and Analysis
- Alkaloids: synthesis and pharmacology
- Remote Sensing and Land Use
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Remote Sensing in Agriculture
- Sleep and Wakefulness Research
- Advanced Neuroimaging Techniques and Applications
- Organic and Inorganic Chemical Reactions
- Protein Kinase Regulation and GTPase Signaling
Kangwon National University Hospital
2015-2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2010-2018
Gyeongsang National University
2018
Scripps Research Institute
1999-2001
Purdue University West Lafayette
1996-1997
Full details of a diastereoselective total synthesis the vancomycin aglycon are described. Two key aromatic nucleophilic substitution macrocyclizations with formation 16-membered diaryl ethers were enlisted for sequential CD and DE ring formations, an effective macrolactamization was developed closure 12-membered biaryl AB system, defined order CD, AB, closures permitted selective thermal atropisomerism newly formed systems or their immediate precursors. This indirect control atropisomer...
The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 CXCL11) have been implicated as playing a central role in directing Th1 inflammatory response. Recent studies strongly support that the is very attractive therapeutic target for treating autoimmune diseases, such rheumatoid arthritis, multiple sclerosis psoriasis, to prevent transplant rejection. We describe here vitro vivo pharmacological characterizations of novel potent small molecule antagonist, SCH 546738. In...
The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 CXCL11) have been implicated as playing a central role in directing Th1 inflammatory response. Recent studies strongly support that the is very attractive therapeutic target for treating autoimmune diseases, such rheumatoid arthritis, multiple sclerosis psoriasis, to prevent transplant rejection. We describe here vitro vivo pharmacological characterizations of novel potent small molecule antagonist, SCH 546738.In...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDiastereoselective Total Synthesis of the Vancomycin Aglycon with Ordered Atropisomer EquilibrationsDale L. Boger, Susumu Miyazaki, Seong Heon Kim, Jason H. Wu, Olivier Loiseleur, and Steven CastleView Author Information Department Chemistry The Skaggs Institute for Chemical Biology Scripps Research 10550 North Torrey Pines Road La Jolla, California 92037 Cite this: J. Am. Chem. Soc. 1999, 121, 13, 3226–3227Publication Date (Web):March 19,...
Full details of studies leading to the total synthesis teicoplanin aglycon are provided. Key elements first generation approach (26 steps from constituent amino acids, 1% overall) include coupling an EFG tripeptide precursor common vancomycin/teicoplanin ABCD ring system and sequential DE macrocyclization 16-membered with formation diaryl ether via a phenoxide nucleophilic aromatic substitution o-fluoronitroaromatic (80%, 3:1 atropisomer diastereoselection) followed by 14-membered FG closure...
The endoplasmic reticulum (ER) is selectively degraded by ER-phagy to maintain cell homeostasis. α-synuclein accumulates in the ER, causing ER stress that contributes neurodegeneration Parkinson’s disease (PD), but role of modulation largely unknown. Here, we investigated mechanisms which recognizes for degradation ER. We found played an important and recovery function through interaction with FAM134B, where calnexin required selective FAM134B-mediated clearance via ER-phagy. Overexpression...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis of the Teicoplanin AglyconDale L. Boger, Seong Heon Kim, Susumu Miyazaki, Harald Strittmatter, Jian-Hui Weng, Yoshiki Mori, Olivier Rogel, Steven Castle, and J. Jeffrey McAteeView Author Information Department Chemistry The Skaggs Institute for Chemical Biology Scripps Research 10550 North Torrey Pines Road, La Jolla, California, 92037 Cite this: Am. Chem. Soc. 2000, 122, 30, 7416–7417Publication Date (Web):July 14,...
The degradation of teicoplanin to a series key aglycon derivatives, including those containing cleaved FG ring system, and study their thermal atropisomerism are detailed. In all cases, selective equilibration the DE system was observed provide 1:1 mixture P:M atropisomers under conditions in which AB CD atropisomer stereochemistry were unaffected. found occur with an Ea 29.3 24.8−25.2 kcal/mol for 6a (FG intact) 10/12 (cleaved system), respectively, is comparable that vancomycin (Ea = 23.6...