A5101991317- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- interferon and immune responses
- T-cell and B-cell Immunology
- Gear and Bearing Dynamics Analysis
- Tribology and Lubrication Engineering
- Chemokine receptors and signaling
- Platelet Disorders and Treatments
- Natural product bioactivities and synthesis
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Nuclear Receptors and Signaling
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Inflammatory mediators and NSAID effects
- Diet and metabolism studies
- Hydraulic and Pneumatic Systems
- Wnt/β-catenin signaling in development and cancer
- Youth Development and Social Support
- Angiogenesis and VEGF in Cancer
- Behavioral Health and Interventions
- Lipid metabolism and disorders
- Virus-based gene therapy research
- Traditional Chinese Medicine Analysis
Xuzhou Medical College
2019-2025
Jiangsu Normal University
2024
Taiyuan University of Technology
2023
Xuzhou Central Hospital
2018-2022
Hubei University of Arts and Science
2016-2021
Xiangyang Central Hospital
2011-2021
Quantitative BioSciences
2021
Konkuk University
2017-2019
Merck & Co., Inc., Rahway, NJ, USA (United States)
2012-2018
Ruijin Hospital
2012
Abstract Background Obesity and inflammation are highly integrated processes in the pathogenesis of insulin resistance, diabetes, dyslipidemia, non-alcoholic fatty liver disease. Molecular mechanisms underlying inflammatory events during high fat diet-induced obesity poorly defined mouse models obesity. This work investigated gene activation signals integral to temporal development Methods Gene expression analysis multiple organs from obese mice was done with Taqman Low Density Array (TLDA)...
Abstract Thrombopoietin (Tpo) is a primary regulator of megakaryocyte and platelet production. However, studies in c-mpl-deficient mice suggest that Tpo might also play an important role early hemopoiesis. Here, the direct ability to stimulate stroma-independent growth, multilineage differentiation, progenitor cell expansion from single primitive CD34+ CD38- human bone marrow cells was investigated. alone stimulated limited clonal but synergized with c-kit ligand (KL), flt3 (FL), or IL-3...
The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 CXCL11) have been implicated as playing a central role in directing Th1 inflammatory response. Recent studies strongly support that the is very attractive therapeutic target for treating autoimmune diseases, such rheumatoid arthritis, multiple sclerosis psoriasis, to prevent transplant rejection. We describe here vitro vivo pharmacological characterizations of novel potent small molecule antagonist, SCH 546738. In...
The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 CXCL11) have been implicated as playing a central role in directing Th1 inflammatory response. Recent studies strongly support that the is very attractive therapeutic target for treating autoimmune diseases, such rheumatoid arthritis, multiple sclerosis psoriasis, to prevent transplant rejection. We describe here vitro vivo pharmacological characterizations of novel potent small molecule antagonist, SCH 546738.In...
Prostaglandin E2 (PGE2), an arachidonic acid pathway metabolite produced by cyclooxygenase (COX)-1/2, has been shown to impair anti-tumor immunity through engagement with one or more E-type prostanoid receptors (EP1-4). Specific targeting of EP receptors, as opposed COX-1/2 inhibition, proposed achieve preferential antagonism PGE2–mediated immune suppression. Here we describe the activity MF-766, a potent and highly selective small-molecule inhibitor EP4 receptor. inhibition MF-766...
The KCNN4 potassium-ion channel has been reported to play an important role in regulating antigen-induced T cell effector functions vitro. This study presents the first evidence that a selective blocker, TRAM-34, confers protection against experimental autoimmune encephalomyelitis (EAE) mouse model. Treatment with blocker did not prevent infiltration of cells spinal cord, but resulted reduction both protein and message levels TNF-alpha IFN-gamma as well several other pro-inflammatory...
Abstract Background Pancreatic cancer (PC) has become the fourth most lethal among human cancers. Long noncoding RNAs (lncRNAs) have been reported to play a role in progression of variety However, lncRNA SNHG1 PC is not clear. Methods Real‐time Quantitative PCR Detection System (qPCR) was used detect expression cells. Then, knockdown cell constructed with si‐SNHG1. AsPC‐1 and PANC1 cells were analyze ability proliferation, invasion, migration. MTT assay proliferation ability. Transwell...
To investigate the effects of anthelminthic drug niclosamide in renal cell carcinoma (RCC) and underlying mechanisms its action. The on proliferation apoptosis RCC cells were examined vitro vivo by using MTS, colony formation assay, flow cytometry xenograft cancer mouse model. Mechanism studies performed analyzing Wnt/β-catenin signaling mitochondrial functions a panel lines. We show that effectively targets two lines through inhibiting anchorage-independent formation, inducing apoptosis. It...
CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus much interest as target for inflammatory disease.Here we examined effects blockade with potent small molecule antagonist determine pharmacodynamic consequences on peripheral blood compartment context acute chronic processes.We demonstrate that antagonism vivo led rapid decrease number circulating Ly6Chi monocytes this was largely due CXCR4-dependent sequestration these cells...
Thrombopoietin (Tpo), the ligand for c-mpl and a principal regulator of megakaryocytopoiesis platelet production, has been demonstrated to stimulate growth differentiation megakaryocyte as well multipotent hemopoietic progenitor cells. In present study we demonstrate that Tpo can adhesion Mo7e cell line fibronectin (Fn) vascular molecule-1 through activation very late antigen (VLA)-4 VLA-5, molecules previously be involved in regulation steady state hemopoiesis. Tpo-induced was concentration...
A high recurrence rate has always been a serious problem for treatment of hepatocellular carcinoma (HCC). Exploring predictors postoperative and posttransplantation in patients with HCC can guide strategies clinicians.In this study, logistic regression multivariate Cox models were constructed microRNA expression profile data from The Cancer Genome Atlas (TCGA) gene omnibus (GEO). accuracy predictions was assessed using receiver operating characteristic curve (ROC) Kaplan‒Meier survival...
This study investigates the behaviors of Large Language Models (LLMs) when faced with conflicting prompts versus their internal memory. will not only help to understand LLMs' decision mechanism but also benefit real-world applications, such as retrieval-augmented generation (RAG). Drawing on cognitive theory, we target first scenario decision-making styles where there is no superiority in conflict and categorize preference into dependent, intuitive, rational/irrational styles. Another...
Meeting abstracts LAG-3 has been shown to act as an inhibitory molecule involved in the regulation of T cell activation, proliferation and homeostasis. Exhausted populations that evolve tumor microenvironment or during chronic viral infections show coordinated expression
Abstract BACKGROUND Compounds of the inner shell chestnut ( Castanea crenata ) have diverse biological activities, including anti‐cancer and anti‐oxidant activities. Here we explored effects an extract shells its bioactive component scoparone on vascular smooth muscle cell migration vessel damage. RESULTS The ethanol shells, containing 11 major compounds, inhibited platelet‐derived growth factor (PDGF)‐BB‐induced rat aortic cells (RASMCs). Among these (6,7‐dimethoxycoumarin) suppressed RASMC...
Background We aimed to analyze the success rates and access patency at 12 months between patients on chronic hemodialysis with symptomatic central venous stenosis (CVS) or occlusion (CVO), receiving high low balloon inflation pressure for treatment.Methods performed a retrospective study in which angioplasty balloons were inflated using low-pressure high-pressure management of CVS/CVO. The outcomes this rate after angioplasty, differences groups compared.Results included total 74 assigned...
The innate immune agonist STING (STimulator of INterferon Genes) binds its natural ligand 2'3'-cGAMP (cyclic guanosine-adenosine monophosphate) and initiates type I IFN production. This promotes systemic antigen-specific CD8+ T-cell priming that eventually provides potent antitumor activity. To exploit this mechanism, we synthesized a novel agonist, MSA-1, activates both mouse human with higher in vitro potency than cGAMP. Following intratumoral administration MSA-1 to panel syngeneic tumors...