A5021876776- Diet and metabolism studies
- Nutritional Studies and Diet
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Diet, Metabolism, and Disease
- Sodium Intake and Health
- Fatty Acid Research and Health
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Blood Pressure and Hypertension Studies
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Health and Risk Factors
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Consumer Attitudes and Food Labeling
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cholesterol and Lipid Metabolism
- Epigenetics and DNA Methylation
- Atherosclerosis and Cardiovascular Diseases
Harvard University
2016-2025
Brigham and Women's Hospital
2014-2024
Harvard University Press
2004-2024
Concord Consortium
2022
GTx (United States)
2021
Pediatrics and Genetics
2018
George Institute for Global Health
2017
Johns Hopkins University
1995-2017
Beth Israel Deaconess Medical Center
1989-2017
The George Institute for Global Health
2017
In patients with high cholesterol levels, lowering the level reduces risk of coronary events, but effect levels in majority disease, who have average is less clear.In a double-blind trial lasting five years we administered either 40 mg pravastatin per day or placebo to 4159 (3583 men and 576 women) myocardial infarction had plasma total below 240 deciliter (mean, 209) low-density lipoprotein (LDL) 115 174 139). The primary end point was fatal event nonfatal infarction.The frequency 10.2...
It is known that obesity, sodium intake, and alcohol consumption influence blood pressure. In this clinical trial, Dietary Approaches to Stop Hypertension, we assessed the effects of dietary patterns on
The effect of dietary composition on blood pressure is a subject public health importance. We studied the different levels sodium, in conjunction with Dietary Approaches to Stop Hypertension (DASH) diet, which rich vegetables, fruits, and low-fat dairy products, persons those without hypertension.
Improving diet and lifestyle is a critical component of the American Heart Association’s strategy for cardiovascular disease risk reduction in general population. This document presents recommendations designed to meet this objective. Specific goals are consume an overall healthy diet; aim body weight; recommended levels low-density lipoprotein cholesterol, high-density triglycerides; normal blood pressure; glucose level; be physically active; avoid use exposure tobacco products. The balance...
The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies extend beyond 1 year.We randomly assigned 811 overweight adults to one four diets; the targeted percentages energy derived from in diets were 20, 15, 65%; 25, 55%; 40, 45%; 35%. consisted similar foods met guidelines cardiovascular health. participants offered group individual instructional sessions 2 years. primary outcome was change body after...
The association of triglycerides with incident cardiovascular disease remains controversial. Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role atherosclerosis.To determine (fasting vs nonfasting) and risk future events.Prospective study 26,509 initially healthy US women (20,118 6391 participating Women's Health Study, enrolled between November 1992 July 1995 undergoing follow-up for a median 11.4 years....
Background —Elevated plasma concentrations of C-reactive protein (CRP) are associated with increased cardiovascular risk. We evaluated whether long-term therapy pravastatin, an agent that reduces risk, might alter levels this inflammatory parameter. Methods and Results —CRP were measured at baseline 5 years in 472 randomly selected participants the Cholesterol Recurrent Events (CARE) trial who remained free recurrent coronary events during follow-up. Overall, CRP highly correlated ( r =0.60,...
We studied whether inflammation after myocardial infarction (MI) is a risk factor for recurrent coronary events and randomized treatment with pravastatin reduces that risk.A nested case-control design was used to compare C-reactive protein (CRP) serum amyloid A (SAA) levels in prerandomization blood samples from 391 participants the Cholesterol Recurrent Events (CARE) trial who subsequently developed nonfatal MI or fatal event (cases) an equal number of age- sex-matched remained free these...
A substantial body of evidence strongly supports the concept that multiple dietary factors affect blood pressure (BP). Well-established modifications lower BP are reduced salt intake, weight loss, and moderation alcohol consumption (among those who drink). Over past decade, increased potassium intake patterns based on “DASH diet” have emerged as effective strategies also BP. Of public health relevance findings related to blacks older individuals. Specifically, especially sensitive...
The independent contributions of subfractions high-density lipoprotein (HDL) cholesterol (HDL2 and HDL3) apolipoproteins in predicting the risk myocardial infarction are unclear. Prospective data sparse, but HDL2 is widely believed to be a more important predictor than HDL3.
High intakes of dietary sugars in the setting a worldwide pandemic obesity and cardiovascular disease have heightened concerns about adverse effects excessive consumption sugars. In 2001 to 2004, usual intake added for Americans was 22.2 teaspoons per day (355 calories day). Between 1970 2005, average annual availability sugars/added increased by 19%, which 76 Americans’ daily energy intake. Soft drinks other sugar-sweetened beverages are primary source diets. Excessive has been linked with...
Postmenopausal estrogen-replacement therapy may reduce the risk of cardiovascular disease, and this beneficial effect be mediated in part by favorable changes plasma lipid levels. However, effects on lipoprotein levels postmenopausal estrogens low doses currently used have not been precisely quantified, mechanism these is unknown.
Reduced intake of saturated fat is widely recommended for prevention cardiovascular disease. The type macronutrient that should replace remains uncertain.To compare the effects 3 healthful diets, each with reduced intake, on blood pressure and serum lipids.Randomized, 3-period, crossover feeding study (April 2003 to June 2005) conducted in Baltimore, Md, Boston, Mass. Participants were 164 adults prehypertension or stage 1 hypertension. Each period lasted 6 weeks body weight was kept...
Although diabetes is a major risk factor for coronary heart disease (CHD), little information available on the effects of lipid lowering in diabetic patients. We determined whether lipid-lowering treatment with pravastatin prevents recurrent cardiovascular events patients CHD and average cholesterol levels.The Cholesterol And Recurrent Events (CARE) trial, 5-year trial that compared effect placebo, included 586 (14.1%) clinical diagnoses diabetes. The participants were older, more obese,...
Background —Levels of tumor necrosis factor-α (TNF-α) increase with acute ischemia. However, whether elevations TNF-α in the stable phase after myocardial ischemia (MI) are associated increased risk recurrent coronary events is unknown. Methods and Results —A nested case-control design was used to compare levels obtained an average 8.9 months initial MI among 272 participants Cholesterol And Recurrent Events (CARE) trial who subsequently developed nonfatal or a fatal cardiovascular event...
In a previous study, higher concordance to the MIND diet, hybrid Mediterranean-Dietary Approaches Stop Hypertension was associated with slower cognitive decline. this study we related these three dietary patterns incident Alzheimer's disease (AD).We investigated diet-AD relations in prospective of 923 participants, ages 58 98 years, followed on average 4.5 years. Diet assessed by semiquantitative food frequency questionnaire.In adjusted proportional hazards models, second (hazards ratio or...
Higher levels of serum phosphate are associated with adverse cardiovascular outcomes, especially in the setting overt hyperphosphatemia. Given biological importance phosphorus, it is plausible that higher within normal range may also be outcomes.We performed a post hoc analysis data from Cholesterol And Recurrent Events (CARE) study. Baseline were measured 4127 fasting participants who randomized to receive pravastatin 40 mg daily or placebo and followed up for median 59.7 months. We used...
The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific the nutrition literature on dementia prevention.
BACKGROUND: Higher levels of red blood cell distribution width (RDW) may be associated with adverse outcomes in patients heart failure. We examined the association between RDW and risk all-cause mortality cardiovascular a population people coronary disease who were free failure at baseline. METHODS AND RESULTS: performed post hoc analysis data from Cholesterol Recurrent Events study. Baseline was measured 4111 participants randomized to receive pravastatin 40 mg daily or placebo followed for...