A5019936714- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vibrio bacteria research studies
- Child Nutrition and Water Access
- Global Socioeconomic and Political Dynamics
- Virology and Viral Diseases
- Dengue and Mosquito Control Research
- Poverty, Education, and Child Welfare
- Immune responses and vaccinations
- Vaccine Coverage and Hesitancy
- Marriage and Family Dynamics
- Legal and Social Justice Studies
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 impact on air quality
- Salmonella and Campylobacter epidemiology
- Global Maternal and Child Health
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cybercrime and Law Enforcement Studies
University of the Philippines Manila
2015-2025
University of the Philippines System
2020-2023
Health and Human Development (2HD) Research Network
2018-2023
National Institutes of Health
2018-2023
Coalition for Epidemic Preparedness Innovations
2021
University of North Carolina at Chapel Hill
2021
Puerto Rico Department of Health
2021
Centers for Disease Control and Prevention
2021
BackgroundA three-dose dengue vaccine (CYD-TDV) was licensed for use in children aged 9 years and older starting 2015 several dengue-endemic countries. In 2016, the Philippine Department of Health implemented a vaccination programme, which discontinued because safety concerns. We assessed relative risk developing virologically confirmed among who did or not receive single dose CYD-TDV by previous virus (DENV) infections at baseline classified as none, one, two more infections.MethodsIn this...
Detection of dengue virus antibodies is important for understanding future risk and prevaccination screening. We aimed to evaluate the performance a IgG indirect ELISA in determining seroprevalence cohort children Philippines, using focus reduction neutralisation test (FRNT) as reference test.In this prospective population-based study, we enrolled healthy residing Bogo or Balamban, Cebu, who were be aged 9-14 years at time mass vaccination campaign. Sera collected from participants batch...
The standard dengue virus (DENV) neutralization assay inconsistently predicts protection. We compare how IgG ELISA, envelope domain III (EDIII), or non-structural protein 1 (NS1) binding antibodies, and titers from plaque reduction tests (PRNTs) using mature viruses are associated with dengue. ELISA measures antibodies that bind to inactivated DENV1-4. EDIII NS1 assays measure the PRNTs neutralizing each specific DENV serotype. Healthy children (n = 1206) in Cebu, Philippines were followed...
Abstract EuCorVac‐19 (ECV‐19) is a recombinant receptor binding domain (RBD) COVID‐19 vaccine that displays the RBD (derived from SARS‐CoV‐2 Wuhan strain) on immunogenic liposomes. This study compares safety and immunogenicity of ECV‐19 to COVISHIELD TM (CS) adenoviral‐vectored vaccine. Interim analysis presented randomized, observer‐blind, immunobridging Phase 3 trial in Philippines 2600 subjects, with treatment biospecimen collection between October 2022 January 2023. Healthy male female...
Background Despite being a cholera-endemic country, data on cholera in the Philippines remain sparse. Knowing areas where is known to occur and factors that lead its occurrence will assist planning preventive measures disaster mitigation. Methods Using sentinel surveillance data, PubMed ProMED searches covering information from 2008–2013 event-based reports 2010–2013, we assessed epidemiology of Philippines. spatial log regression, role water, sanitation population density incidence cholera....
ObjectiveVaccination with the first licensed dengue vaccine is recommended only for those who have had previous infection virus (DENV). A point-of-care test desired sensitivity of 95% and specificity 98% could facilitate pre-vaccination screening. We evaluated a newly developed, automated immunoglobulin fluorescence immunoassay determining serostatus.MethodsWe used serum samples collected just prior to mass vaccination in Cebu, Philippines. Healthy children residing Bogo Balamban would be...
Dengue seroprevalence data are useful for understanding epidemiologic trends and transmission dynamics, making decisions about implementation of dengue control programs. A logistical challenge to surveys is the collection transport serum samples. For conducting large repeated serosurveys, dried blood spots (DBS) would allow easier sample collection, shipment, transport, storage than standard methods. Further evidence needed understand how well DBS performs compared with methods in laboratory...
Dengue fever is an important public health problem in the Philippines. In April 2016, Department of Health launched a three-dose school based dengue vaccination program nine- to fourteen-year-old children three regions with highest number cases using CYD-TDV (Dengvaxia, Sanofi Pasteur). July 2017, community-based was implemented Cebu province. The discontinued December 2017 amidst controversy, after first dose had been administered. We assessed effectiveness single against hospitalized...
Recent work demonstrates the limitations of standard dengue virus (DENV) neutralization assay to predict protection against dengue. We perform studies compare how a commercial IgG ELISA, envelope domain III (EDIII) or non-structural protein 1 (NS1) binding antibodies, and titers from plaque reduction tests (PRNTs) using reference clinical mature viruses are associated with disease. Healthy children (n = 1,206) in Cebu, Philippines were followed for 5 years. High ELISA values (≥3) reduced...
SARS-CoV-2 serological testing is useful to determine seroprevalence, epidemiological trends, and the extent of transmission. The collection transport serum samples can be logistically challenging, especially in remote underserved areas. Dried blood spots (DBSs) would allow easier sample logistical handling compared with standard collection, particularly for extensive repeated serosurveys. We evaluated sensitivity, specificity, positive predictive value (PPV), negative (NPV) IgG ELISA...
Background. Measles cases have decreased ever since vaccination has been introduced through the DOH Expanded Program on Immunization (DOH EPI) in Philippines. Elimination is current goal. However, despite high vaccine coverage, a nationwide outbreak occurred 2013.
 Objectives. This study aimed to present measles incidence rates before and after introduction of vaccine, describe changing epidemiology measles, assess effectiveness baseline reporting.
 Methods. National data from 1960...
Zika virus (ZIKV) is a member of the Flaviviridae family, which includes other clinically notable viruses such as 4 dengue serotypes (DENV-1-4). Distinguishing DENVs from ZIKV using established serologic assays widely used for monitoring DENV transmission difficult because antibody cross-reactivity between these closely related flaviviruses. We describe modified and improved recombinant envelope domain III-based assay detecting type-specific antibodies in regions with endemic transmission....
Abstract Cross-reactive antibodies (Abs) to epitopes that span envelope proteins on the virion surface are hypothesized protect against dengue. Here, we measured Abs targeting quaternary dimer epitope (EDE) as well neutralizing and binding evaluate their association with dengue virus (DENV) infection, vaccine response, disease outcome in vaccinated unvaccinated children (n=252) within a longitudinal cohort Cebu, Philippines (n=2,996). EDE were prevalent strongly associated broad...
Pandemics and natural disasters are recognized to cause major disruptions. The main objective of this study was explore the impacts COVID-19 supertyphoon Odette in Cebu, Philippines. A total 2630 participants were interviewed exploring Odette. majority respondents (2486/2630; 94.5%) had financial problems due COVID-19. Almost three out four (1962/2630; 74.6%) experienced moderate severe impact on their mental health. a third (874/2630; 33.2%) reported physical well-being, mostly related...
Phase 3, randomized, controlled, multicenter, equivalence trial.Recruitment of participants occurred between 04Februray2020 and 15July2020 at four centers in the Philippines: University East - Ramon Magsaysay Memorial Medical Center Inc., Quezon City; Philippines Manila National Institute Health, Ermita Manila; Asian Hospital Center, Metro Manila, Study; Research Unit, Tropical Disease Foundation, Makati City, Philippines.1800 adults children 6-months to 45-years age.Participants received a...
To assess the prevalence of hepatitis B in Philippines, we conducted a cross-sectional study among 5 to 6 year old children born 2007–2008, when birth dose started be implemented country. The was from 25 July 22 October 2013 24 provinces and used 3-stage cluster design probability-proportional size sampling. Blood obtained sera were tested for surface antigen (HBsAg). survey included 2,769 children, whom 26% received timely (within hours birth) 89% 3 doses vaccine. Due problems initial...
Background. Deaths may occur due to complications of measles. The most common measles complication is pneumonia and accounts for measles-related deaths.
 Objective. study aimed identify risk factors developing among cases.
 Methodology. A cross-sectional was conducted using surveillance data from an outbreak in the Philippines January 2013 December 2014. Data on age, sex, area residence, clinical manifestations, receipt vaccine, other exposure variables were obtained analyzed...