A5004233631- Vibrio bacteria research studies
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- HIV Research and Treatment
- Escherichia coli research studies
- Child Nutrition and Water Access
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Pneumonia and Respiratory Infections
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Malaria Research and Control
- HIV/AIDS Research and Interventions
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Salmonella and Campylobacter epidemiology
- Tuberculosis Research and Epidemiology
- Aquaculture disease management and microbiota
- Renal Transplantation Outcomes and Treatments
- Global Maternal and Child Health
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Travel-related health issues
University of the Philippines Manila
2014-2024
Institute for Bioengineering of Catalonia
2022
Puerto Rico Department of Health
2021
Centers for Disease Control and Prevention
2021
Coalition for Epidemic Preparedness Innovations
2021
University of the Philippines System
1997-2021
University of North Carolina at Chapel Hill
2021
Universitat Autònoma de Barcelona
2018
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2018
Johns Hopkins University
2017
Background The global burden of cholera is largely unknown because the majority cases are not reported. low reporting can be attributed to limited capacity epidemiological surveillance and laboratories, as well social, political, economic disincentives for reporting. We previously estimated 2.8 million 91,000 deaths annually due in 51 endemic countries. A major limitation our previous estimate was that non-endemic countries were defined based on countries' reported cases. overcame with use a...
To estimate the global burden of cholera using population-based incidence data and reports.
Cholera remains an important public health problem. Yet there are few reliable population-based estimates of laboratory-confirmed cholera incidence in endemic areas around the world.We established treatment facility-based surveillance three sites Jakarta (Indonesia), Kolkata (India), and Beira (Mozambique). The annual was estimated using population census as denominator age-specific number cases among study cohort numerator.The lowest overall rate found Jakarta, where 0.5/1000...
Therapeutic immunization with autologous monocyte-derived dendritic cells (DCs) loaded heat-inactivated human immunodeficiency virus type 1 (HIV-1) in 12 patients chronic HIV-1 infection who were receiving highly active antiretroviral therapy (HAART) was feasible, safe, and well tolerated. Virus obtained during an initial interruption of HAART (hereafter, "stop 1") so that DCs could be pulsed. After a second 2"), set-point plasma viral load (PVL; 24 weeks after stop 2) decreased ⩾0.5 log10...
Background Killed oral cholera vaccines (OCVs) have been licensed for use in developing countries, but protection conferred by OCVs beyond two years of follow-up has not demonstrated randomized, clinical trials. Methods/Principal Findings We conducted a cluster-randomized, placebo-controlled trial two-dose regimen low-cost killed whole cell OCV residents 1 year age and older living 3,933 clusters Kolkata, India. The primary endpoint was culture-proven Vibrio cholerae O1 diarrhea episodes...
Introduction Mass vaccinations are a main strategy in the deployment of oral cholera vaccines. Campaigns avoid giving vaccine to pregnant women because absence safety data killed whole-cell (rBS-WC) vaccine. Balancing this concern is known higher risk and complications pregnancy should occur these women, as well lack expected adverse events from bacterial Methodology/Principal Findings From January February 2009, mass rBS-WC vaccination campaign persons over two years age was conducted an...
BackgroundA three-dose dengue vaccine (CYD-TDV) was licensed for use in children aged 9 years and older starting 2015 several dengue-endemic countries. In 2016, the Philippine Department of Health implemented a vaccination programme, which discontinued because safety concerns. We assessed relative risk developing virologically confirmed among who did or not receive single dose CYD-TDV by previous virus (DENV) infections at baseline classified as none, one, two more infections.MethodsIn this...
An effective vaccine against cholera has been used for public health purposes in Vietnam since the 1990s. This was reformulated to meet WHO requirements. We assessed safety and immunogenicity of bivalent (Vibrio cholerae 01 0139) killed whole cell oral a endemic area Kolkata, India.Double-blind, randomized, placebo controlled trial.The trial conducted clinical ward Infectious Diseases Hospital India.The participants were 101 healthy adults (males non-pregnant females) aged 18-40 years 100...
Vibrio cholerae O1 isolates collected during cholera outbreaks occurring from late 2007 to early 2008 in northern Vietnam were revealed represent an altered strain containing the RS1 element followed by a CTX prophage harboring El Tor type rstR and classical ctxB on large chromosome.
Background. We evaluated the herd protection conferred by an oral cholera vaccine using 2 approaches: cluster design and geographic information system (GIS) design.
Introduction The outbreak of cholera in Zimbabwe intensified interest the control and prevention cholera. While there is agreement that safe water, sanitation, personal hygiene are ideal for long term cholera, controversy about role newer approaches such as oral vaccines (OCVs). In October 2009 Strategic Advisory Group Experts advised World Health Organization to consider reactive vaccination campaigns response large outbreaks. To evaluate potential benefit this pivotal change WHO policy, we...
Killed oral cholera vaccines (OCVs) are available but not used routinely for control except in Vietnam, which produces its own vaccine. In 2007-2008, unprecedented outbreaks occurred the capital, Hanoi, prompting immunization two districts. an outbreak investigation, we assessed effectiveness of killed OCV use after a began.From 16 to 28 January 2008, vaccination campaigns with Vietnamese were held districts Hanoi. No cases detected from 5 February 4 March again identified. Beginning 8 April...
The substantial morbidity and mortality associated with recent cholera outbreaks in Haiti Zimbabwe, as well endemicity countries throughout Asia Africa, make a compelling case for supplementary control measures addition to existing interventions. Clinical trials conducted Kolkata, India, have led World Health Organization (WHO)-prequalification of Shanchol, an oral vaccine (OCV) demonstrated 65% efficacy at 5 years post-vaccination. However, before this is widely used endemic areas or risk...
Detection of dengue virus antibodies is important for understanding future risk and prevaccination screening. We aimed to evaluate the performance a IgG indirect ELISA in determining seroprevalence cohort children Philippines, using focus reduction neutralisation test (FRNT) as reference test.In this prospective population-based study, we enrolled healthy residing Bogo or Balamban, Cebu, who were be aged 9-14 years at time mass vaccination campaign. Sera collected from participants batch...
The objective of the study was to examine effect ranitidine on incidence late onset sepsis.This based information extracted from charts 569 infants admitted neonatal intensive care unit (NICU) July 2003 2005. All for seven or more days were included. Late-onset sepsis defined as a positive blood culture with clinical signs after life. Outcome measures included use ranitidine, type infection and infectious agent, birth weight gestational age, in NICU.Of admitted, 53 (9.3%) treated ranitidine....