A5084437019- Neutropenia and Cancer Infections
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Herpesvirus Infections and Treatments
- Antibiotic Resistance in Bacteria
- Hepatitis Viruses Studies and Epidemiology
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Animal Virus Infections Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Mycology
- Syphilis Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Infections and bacterial resistance
- Bartonella species infections research
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- Sinusitis and nasal conditions
- Antimicrobial Resistance in Staphylococcus
- Venous Thromboembolism Diagnosis and Management
- Pediatric health and respiratory diseases
- Acne and Rosacea Treatments and Effects
- Polyomavirus and related diseases
- Oral health in cancer treatment
- Glioma Diagnosis and Treatment
Catholic University of Korea
2015-2024
Bucheon St. Mary's Hospital
2016-2023
Institut de Recherche Vaccinale
2017
St. Paul's Hospital
2015
Woosuk University
2010
Stenotrophomonas maltophilia causes serious infections in immunocompromised hosts. Here, we analyzed the clinical characteristics of S. bloodstream infection (BSI) patients with hematologic malignancies and evaluated vitro synergistic effects antimicrobial combinations. We retrospectively reviewed all consecutive episodes BSIs adult from June 2009 to May 2014, susceptibility synergy tests using high-throughput bioluminescence assay performed for available isolates. Among 11,004 admissions...
Global data on the epidemiology and susceptibility of Aspergillus are crucial in management invasive aspergillosis. Here, we aimed to determine characteristics clinical environmental isolates, focusing mainly hematologic malignancy patients.
Abstract Background Numerous vaccine strategies are being advanced to control SARS-CoV-2, the cause of COVID-19 pandemic. EuCorVac-19 (ECV19) is a recombinant protein nanoparticle that displays SARS-CoV-2 receptor-binding domain (RBD) on immunogenic nanoliposomes. Methods Initial study phase 2 randomized, observer-blind, placebo-controlled trial assess immunogenicity, safety, and tolerance ECV19 was carried out between July October 2021. Two hundred twenty-nine participants were enrolled at...
Abstract Background Vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI) is generally associated with the delayed administration of adequate antibiotics. The identification risk factors and outcomes VRE BSI necessary for establishing strategies managing neutropenic fever in patients hematological malignancies. Methods We retrospectively analysed consecutive cases enterococcal neutropenia after chemotherapy or stem cell transplantation between July 2009 December 2011 at a...
Background: Carbapenemase-producing Enterobacteriaceae (CPE) are Gram-negative bacteria with increasing prevalence of infection worldwide.In Korea, 25 cases CPE isolates were reported by the Korea Centers for Disease Control and Prevention in 2011.Most detected mainly at tertiary referral hospitals.We analyzed risk factors carbapenem-resistant (CRE) a mid-sized community-based hospital Korea. Materials Methods:We retrospectively all consecutive episodes from January 2013 to February 2014.CRE...
The risk factors and clinical impacts of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) remain controversial, no data have been reported in Korea. This study aimed to investigate the epidemiology importance CAPA diagnostic efforts identify predictors on outcomes.Between January 2020 May 2021, severely critically ill COVID-19 patients were extracted from seven hospitals Catholic Medical Center through a warehouse. Corticosteroid use was subcategorized into total...
EuCorVac-19 (ECV-19), an adjuvanted liposome-displayed receptor binding domain (RBD) COVID-19 vaccine, previously reported interim Phase 2 trial results showing induction of neutralizing antibodies 3 weeks after prime-boost immunization. The objective this study was to determine the longer-term antibody response vaccine.To assess immunogenicity 6 and 12 months vaccination, participants in (NCT04783311) were excluded if they: 1) withdrew, 2) infection or additional 3) exhibited increasing...
Background:The aim of this study was to investigate the clinical features and epidemiology bloodstream infections (BSIs) in 2 distinctive hematological wards Catholic Blood Marrow Transplantation (BMT) center. Materials Methods:We retrospectively reviewed medical data patients who developed BSIs from June 2009 May 2010 hematologic at BMT center.Ward A is a 44-bed unit mainly conducting conventional high dose chemotherapy ward B 23-bed exclusively BMT.Results: Overall, 222 BSI episodes were...
Incidence, epidemiology, and risk factors of invasive fungal diseases (IFDs) in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients can vary from different cohorts countries. Therefore, we performed a nationwide study to establish proper antifungal prophylaxis strategies based on stratifications IFDs after all-HSCT Korea (RISK study). This was multicenter, retrospective, observational Korea. All consecutive adult patients who received allo-HSCT 2013 were included. The...
Background: In South Korea, the one-dose varicella vaccine was included in National Immunization Program for children aged 12–15 months 2005, and coverage reached >95%. The impact of vaccination on herpes zoster (HZ) investigated, accounting demographic changes over time.Methods: We calculated crude age-sex standardized incidence rates (IRs) age-specific IRs HZ from 2003 to 2015, using Health Information Database including approximately 50 million Koreans. annual rate ratios (IRRs) were a...
Vaccination with an adenoviral vector vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can result in the rare development of thrombosis thrombocytopenia mediated by platelet-activating antibodies platelet factor 4 (PF4). This is a life-threating condition that may be accompanied bleeding due to cerebral venous sinus or splanchnic vein. Herein, we describe first fatal case Korea, presenting intracranial hemorrhage caused thrombosis. A 33-year-old Korean man...
Background The risk of developing tuberculosis (TB) in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is expected to be relatively high an intermediate TB burden country. This single-center retrospective study was conducted investigate factors and the incidence after HSCT. Methods From January 2004 March 2011, 845 adult patients were enrolled. Starting April 2009, given isoniazid (INH) prophylaxis based on interferon-γ release assay results. analyzed before compared it...
Breakthrough invasive fungal diseases (bIFDs) during voriconazole treatment are concerning, as they associated with high rates of mortality and pathogen distribution. To evaluate the prevalence, incidence, patient characteristics, including IFD events, overall bIFDs for aspergillosis (IA). We retrospectively analyzed medical records consecutive patients who had undergone IA bIFD events between January 2011 December 2015. Eleven occurred in 9 patients. The prevalence incidence were 2.25%...
Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is increasingly identified as a cause of acute pyelonephritis (APN) among patients without recent health care contact, i.e., community-associated APN. This case-control study compared 75 cases ESBL-EC APN (CA-ESBL) to 225 controls non-ESBL-EC (CA-non-ESBL) identify the risk factors for acquisition and investigate impact ESBL on treatment outcomes (CA-APN) caused by E. at Korean hospital during 2007 2013. The baseline...
Although yeast bloodstream infections (BSIs) are increasingly being reported in patients with hematological malignancies undergoing antifungal therapy, clinical information regarding breakthrough is scarce. The aim of this study was to determine the risk factors for and outcomes BSIs era newer agents. Between 2011 2014, all consecutive who developed were included a case-control wherein (cases) de novo (controls) compared. Of 49 BSIs, 21 (43%) met criteria infections. proportions Candida...
Dasatinib, a tyrosine kinase inhibitor, is widely used for patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Although the drug has potent immunosuppressive effect, infectious complications during dasatinib treatment have been reported rarely. We describe five who developed cytomegalovirus (CMV) colitis treatment, in whom was initially confused other causes. The patients, three leukemia, two were diagnosed CMV based on endoscopic...
In South Korea, despite the implementation of a universal single-dose vaccination program for children aged 12–15 months in 2005, varicella incidence rate remains significant. Prior case-control studies have reported that currently used vaccines are extremely inefficacious. We estimated vaccine effectiveness (VE) by fitting dynamic transmission model to age-specific data from 2007 2015 and available coverage data. The initial efficacy primary failure rates were be 61.1% 38.9%, respectively....
While the epidemiology and clinical differences of various Candida spp. has been relatively well-identified, data regarding invasive aspergillosis (IA) caused by different Aspergillus are insufficient. We aimed to determine culture-positive pulmonary (IPA) compare characteristics outcomes fumigatus IPA with those non-fumigatus in patients hematologic diseases. All consecutive cases from 2011 2015 were reviewed retrospectively. There 430 proven/probable 76 IPA. Excluding multiple species...
With the rise in multidrug-resistant (MDR) bacterial infections, there has been increasing interest combinations of ≥2 antimicrobial agents with synergistic effects. We established an MDR strain library to screen for vitro synergy by using a broth microdilution checkerboard method and high-throughput luciferase-based cell viability assay. In total, 39 strains, including 23 carbapenem-resistant gram-negative bacteria, 9 vancomycin-intermediate Staphylococcus aureus, 7 vancomycin-resistant...
Because primary antifungal prophylaxis is widely used for immunocompromised hosts, the incidences of unusual fungal infections have increased. Trichosporon asahii has emerged as an important life-threatening opportunistic systemic pathogen because increased use cytotoxic or immunosuppressant agents, along with high mortality rates. Here, we describe a case catheter-related T. bloodstream infection multiple septic skin nodules in both arms and legs patient who was neutropenic period after...
PurposePosaconazole is effective for the prophylaxis of invasive fungal infections (IFIs) in patients with acute myeloid leukemia or myelodysplastic syndrome during remission induction chemotherapy. However, a cost–benefit analysis posaconazole versus fluconazole itraconazole has not been conducted Korea.MethodsWe retrospectively reviewed data all consecutive who received primary antifungal chemotherapy our leukemia/myelodysplastic cohort from December 2010 to November 2013. Patient...
Streptococcus suis is a zoonotic pathogen that can cause severe systemic infections in humans as well swine. In recent decades, the number of S. has increased, particularly Southeast Asia. Although most cases human are reported sporadic, few outbreaks have been noted. Interestingly, these proposed to be associated with concomitant Korea, four sporadic and non-fatal infection reported. We herein report case life-threating sepsis for first time Korea. The patient was healthy pig farmer,...