A5049576659- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Bone Metabolism and Diseases
- Medicinal Plant Pharmacodynamics Research
- Nuclear Receptors and Signaling
- Neurological disorders and treatments
- Piperaceae Chemical and Biological Studies
- Water Quality and Pollution Assessment
- Inflammasome and immune disorders
- Autism Spectrum Disorder Research
- Heavy metals in environment
- Geochemistry and Elemental Analysis
- RNA regulation and disease
- Adenosine and Purinergic Signaling
- Cancer-related molecular mechanisms research
- Botulinum Toxin and Related Neurological Disorders
- MicroRNA in disease regulation
Hallym University
2020-2024
University of Veterinary Medicine Hannover, Foundation
2023
Hallym University Sacred Heart Hospital
2021-2022
Vietnam National University, Hanoi
2019-2021
VNU University of Science
2019-2021
Yonsei University
2021
Vietnam Academy of Science and Technology
2021
Abstract The accumulation of alpha-synuclein (αSyn) is widely recognized as the main pathological process in Parkinson’s disease (PD). Additionally, neuroinflammation considered to be one contributing mechanisms development PD. In light this, it hypothesized that reactive microglia exacerbate propagation αSyn and neurodegeneration, while inhibition microglial activity may mitigate these effects. To test this hypothesis, preformed fibrils (PFF)-injected PD mouse model was employed....
According to a few studies, α-synuclein (αSyn) propagation has been suggested play key role in the pathomechanism of Parkinson's disease (PD), but neurodegeneration and involvement inflammation its pathologic progression are not well understood with regard temporal relationship. In this study, help PD mouse model injected intrastriatal αSyn preformed fibril (PFF), evolution propagation, inflammation, was explored perspective striatum whole brain. PFF-injected striatum, inflammatory response...
Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological hallmark Parkinson's disease (PD). In addition, accumulating evidence indicates that activated inflammatory responses are involved the pathogenesis PD. Thus, achieving better understanding interaction between inflammation and synucleinopathy relation to PD process will facilitate development promising disease-modifying therapies. this review, discussed, human, animal, laboratory studies relevant relationship...
Abstract Given the limitations and side effects of many synthetic drugs, natural products are an important alternative source for drugs medications diseases. Icariin (ICA), one main flavonoids from plants Epimedium genus, has been shown to ameliorate osteoporosis improve bone health in preclinical studies. Those studies have used different vivo models, mostly rodents, but underlying mechanisms remain unclear. The present study shows, first time, that ICA reduces damage a Rankl‐induced medaka...
Background: Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive Parkinson’s disease (PD) and contribute to the risk of sporadic PD. However, relationship between PD-related PINK1 mutations alpha-synuclein (α-syn) aggregation—a main pathological component PD—remains unexplored. Objective: To investigate whether α-syn pathology is exacerbated absence after preformed fibril (PFF) injection a PD mouse model its effects on neurodegeneration. Methods: In this study,...
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Abstract – HCTN7. Plasma cholesterol level plays an important role in atherosclerosis and cardiovascular diseases. Piperine, alkaloid form of black pepper is known to reduce uptake. In this paper, piperine-loaded chitosan nanoparticles (CTS-PIP NPs) were prepared by ionic gelation method. Molecular interactions among the components confirmed FT-IR spectroscopy. Transmission electron microscopy (TEM) images revealed spherical-shaped with diameter <100 nm. CTS-PIP NPs displayed positive...
Abstract Alpha-synuclein (αSyn) propagation has been determined to play a key role in the pathomechanism of Parkinson’s disease (PD), but neurodegeneration and involvement inflammation its pathologic progression are yet be well understood with regard temporal relationship. In this study, by means PD mouse model injected intrastriatal αSyn preformed fibril (PFF), evolution propagation, inflammation, was explored perspective striatum whole brain. PFF-injected striatum, inflammatory responses...