A5011303634- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Bone health and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Developmental Biology and Gene Regulation
- Curcumin's Biomedical Applications
- Reproductive biology and impacts on aquatic species
- Nanoparticle-Based Drug Delivery
- Medicinal Plant Pharmacodynamics Research
- Birth, Development, and Health
- Bone health and osteoporosis research
- Bone and Dental Protein Studies
- Animal Genetics and Reproduction
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- Congenital heart defects research
- Nanoplatforms for cancer theranostics
- Zebrafish Biomedical Research Applications
- Regulation of Appetite and Obesity
- Cancer-related molecular mechanisms research
VNU University of Science
2019-2023
Vietnam National University, Hanoi
2019-2021
National University of Singapore
2011-2015
Singapore Bioimaging Consortium
2012-2015
University of Würzburg
2003-2006
Osteoclasts are macrophage-related bone resorbing cells of hematopoietic origin. Factors that regulate osteoclastogenesis great interest for investigating the pathology and treatment diseases such as osteoporosis. In mammals, receptor activator NF-κB ligand (Rankl) is a regulator osteoclast formation activation: its misexpression causes stimulation osteoporotic loss. Here, we report an phenotype induced by overexpression Rankl in medaka model. We generated transgenic lines express GFP under...
To further elucidate pituitary adrenal interactions during development, we studied the organogenesis of interrenal organ, teleost homolog mammalian gland, in zebrafish. this end compared wild-type zebrafish development with that mutants lacking cell types including corticotrophs. In addition, effects ACTH receptor (Mc2r) knockdown and dexamethasone (dex) on feedback. Until 2 d post fertilization (2 dpf) assessed by transcripts key steroidogenic genes (cyp11a1, mc2r, star) is independent...
(1) Background: Magnetite (Fe3O4) nanoparticles have great potential for biomedical applications, including hyperthermia and magnetic resonance imaging. In this study, we aimed to identify the biological activity of nanoconjugates composed superparamagnetic Fe3O4 coated with alginate curcumin (Fe3O4/Cur@ALG) in cancer cells. (2) Methods: The were evaluated biocompatibility toxicity on mice. MRI enhancement capacities Fe3O4/Cur@ALG determined both vitro vivo sarcoma models. (3) Results:...
Osteoclasts are bone resorbing cells derived from the monocyte/macrophage lineage. Excess osteoclast activity leads to reduced mineral density, a hallmark of diseases such as osteoporosis. Processes regulating therefore targeted in current osteoporosis therapies. To identify and characterize drugs for treatment diseases, suitable vivo models needed complement cell culture assays. We have earlier reported transgenic medaka lines expressing osteoclast-inducing factor Receptor Activator Nuclear...
Although curcumin in the form of nanoparticles has been demonstrated as a potential anti-tumor compound, impact and nanocurcumin vitro on normal cells vivo animal models is largely unknown. This study evaluated toxicity curcumin-loaded micelles several tumor cell lines, primary stromal cells, zebrafish embryos. Breast line (MCF7) (human umbilical cord vein endothelial human fibroblasts, cord-derived mesenchymal stem cells) were used this study. A embryotoxicity (FET) assay was conducted...
Tetrapod vertebrae are sclerotome-derived metameric structures. Cells from this tissue provide cartilage that surrounds the notochord and give rise to vertebral centrum as well arches. Eventually, later on, is remodeled into bone. Vertebral body development in teleost fish different, since mineralization of sheath first step formation no involved process. Thus, sclerotomal contribution early has been questioned. In contrast, arches often have cartilaginous precursors. short review we compare...
Abstract Given the limitations and side effects of many synthetic drugs, natural products are an important alternative source for drugs medications diseases. Icariin (ICA), one main flavonoids from plants Epimedium genus, has been shown to ameliorate osteoporosis improve bone health in preclinical studies. Those studies have used different vivo models, mostly rodents, but underlying mechanisms remain unclear. The present study shows, first time, that ICA reduces damage a Rankl‐induced medaka...
Objective: To assess the expression level of osteoblast-specific collagen10a1 gene and degree bone mineralization during early larval stages col10a1:nlGFP transgenic medaka fish to identify a specific developmental time window suitable for conducting anabolic effect evaluations bioactive substances. Methods: Homozygous hemizygous groups at 7, 9, 10, 11, 14 days post fertilization (dpf) were used in study (n=…/group). The subjected live staining with alizarin red S (ARS) dye visualize their...