A5080420508- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Voice and Speech Disorders
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Sleep and Wakefulness Research
- Dysphagia Assessment and Management
- Olfactory and Sensory Function Studies
- Parkinson's Disease and Spinal Disorders
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Technology Use by Older Adults
- Brain Tumor Detection and Classification
- Mobile Health and mHealth Applications
- Clinical Reasoning and Diagnostic Skills
- HIV/AIDS Impact and Responses
- Educational Games and Gamification
- Global Public Health Policies and Epidemiology
- Neurology and Historical Studies
- Advanced Neuroimaging Techniques and Applications
- Biochemical Analysis and Sensing Techniques
- History of Medical Practice
TU Dresden
2014-2024
University Hospital Carl Gustav Carus
2019-2024
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2023
John Wiley & Sons (United States)
2023
Hospital de Santa Maria
2022
University of Lausanne
2022
University of Lisbon
2022
University Hospital of Lausanne
2022
Klinik und Poliklinik für Neurologie
2017-2020
King's College Hospital NHS Foundation Trust
2014-2017
Objective Decrease of olfactory function in Parkinson's disease (PD) is a well-investigated fact. Studies indicate that pharmacological treatment PD fails to restore patients. The aim this investigation was whether patients with would benefit from "training" odors terms an improvement their general function. It has been hypothesized training should produce both improved sensitivity towards the used process and overall increase Methods We recruited 70 subjects loss into single-center,...
Abstract Different stages of Parkinson’s disease (PD) are defined by clinical criteria, while late-stage PD is marked the onset morbidity milestones and rapid deterioration. Based on neuropathological evidence, degeneration in dopaminergic system occurs primarily early stage PD, raising question what drives progression PD. This study aimed to investigate whether associated with increased neurodegeneration dynamics rather than functional decompensation using blood-based biomarker serum...
Parkinson's Disease (PD) is a progressive neurodegenerative disorder, manifesting with subtle early signs, which, often hinder timely and diagnosis treatment. The development of accessible, technology-based methods for longitudinal PD symptoms tracking in daily living, offers the potential transforming disease assessment accelerating diagnosis.A privacy-aware method classifying patients healthy controls (HC), on grounds speech impairment present PD, proposed. Voice features from running...
Abstract Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, affecting more than 1% of population above 60 years old with both motor and non-motor symptoms escalating severity as it progresses. Since cannot be cured, treatment options focus on improvement PD symptoms. In fact, evidence suggests that early intervention has potential to slow down symptom progression improve general quality life in long term. However, initial are usually very subtle and, a result,...
Night-time sleep disturbances are important non-motor symptoms and key determinants of health-related quality life (HRQoL) in patients with Parkinson's disease (PD). The KinetiGraph (PKG) can be used as an objective measure different motor states periods immobility may reflect episodes sleep. Our aim was to evaluate whether PKG marker disturbed night-time PD.In this prospective comparative study, data from recordings over six consecutive 24 h compared Hauser diaries scales focusing on state,...
Parkinson's Disease (PD) is a neurodegenerative disorder with early non-motor/motor symptoms that may evade clinical detection for years after the disease onset due to their mildness and slow progression. Digital health tools process densely sampled data streams from daily human-mobile interaction can objectify monitoring of behavioral patterns change appearance PD-related signs. In this context, touchscreens capture micro-movements fingers during natural typing; an unsupervised activity...
Abstract Fine-motor impairment (FMI) is progressively expressed in early Parkinson’s Disease (PD) patients and now known to be evident the immediate prodromal stage of condition. The clinical techniques for detecting FMI may not robust enough here, we show that subtle PD can effectively estimated from analysis natural smartphone touchscreen typing via deep learning networks, trained stages initialization fine-tuning. In a validation dataset 36,000 sessions 39 subjects (17 healthy/22 with...
Background and purpose Neurology is rapidly evolving as a result of continuous diagnostic therapeutic progress, which influences the daily work neurologists. Therefore, updating residency training programmes crucial for future neurology. Several countries are currently discussing and/or modifying structure their neurology programme. A detailed up‐to‐date overview available European will aid this process. Methods questionnaire addressing numerous aspects in was distributed among 38 national...
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder with both motor and non-motor symptoms. Despite the progressive nature of PD, early diagnosis, tracking disease’s natural history measuring drug response are factors that play major role in determining quality life affected individual. Apart from common symptoms, i.e., tremor at rest, rigidity bradykinesia, studies suggest PD associated disturbances eating behavior energy intake. Specifically, drug-induced impulsive disorders...
Parkinson's Disease (PD) is a slowly evolving neuro-logical disease that affects about 1% of the population above 60 years old, causing symptoms are subtle at first, but whose intensity increases as progresses. Automated detection these could offer clues to early onset disease, thus improving expected clinical outcomes patients via appropriately targeted interventions. This potential has led many researchers develop methods use widely available sensors measure and quantify presence PD such...
The effects of subthalamic stimulation (subthalamic nucleus-deep brain stimulation, STN-DBS) on impulsive and compulsive behaviours (ICB) in Parkinson's disease (PD) are understudied.To investigate clinical predictors STN-DBS ICB.In this prospective, open-label, multicentre study patients with PD undergoing bilateral STN-DBS, we assessed preoperatively at 6-month follow-up postoperatively. Clinical scales included the Questionnaire for Impulsive-Compulsive Disorders PD-Rating Scale...
Parkinson's Disease (PD) is the second most common neurodegenerative disorder worldwide, causing both motor and non-motor symptoms. In early stages, symptoms are mild patients may ignore their existence. As a result, they do not undergo any related clinical examination; hence delaying PD diagnosis. an effort to remedy such delay, analysis of data passively captured from user's interaction with consumer technologies has been recently explored towards remote screening signs. current study,...
Human-Computer Interaction (HCI) and games set a new domain in understanding people’s motivations gaming, behavioral implications of game play, adaptation to player preferences needs for increased engaging experiences the context HCI serious (HCI-SGs). When latter relate with health status, they can become part their daily life as assistive status monitoring/enhancement systems. Co-designing HCI-SGs be seen combination art science that involves meticulous collaborative process. The design...