A5022419322- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Cognitive Abilities and Testing
- Restless Legs Syndrome Research
- Cognitive Functions and Memory
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Sleep and related disorders
- Blood Pressure and Hypertension Studies
- Stroke Rehabilitation and Recovery
- Health, Environment, Cognitive Aging
- Aging and Gerontology Research
- Autism Spectrum Disorder Research
- Children's Physical and Motor Development
- Advanced Neuroimaging Techniques and Applications
- Balance, Gait, and Falls Prevention
- Mind wandering and attention
- Medical Practices and Rehabilitation
- Olfactory and Sensory Function Studies
- Technology Use by Older Adults
University of Cologne
2020-2025
University Hospital Cologne
2018-2025
Forschungszentrum Jülich
2025
Johnson Matthey (Germany)
2023
Jewish General Hospital
2022
McGill University
2022
Gender Studies
2018-2021
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) highlights an early α-synucleinopathy. This study compared health-related quality of life (hrQoL) in 62 individuals with iRBD 19 healthy controls (HC) and 29 Parkinson's disease (PD) identified factors linked to poorer hrQoL. HrQoL was significantly lower (83.33 ± 16.96) HC (92.29 5.49, p = 0.027). Poorer hrQoL severity multiple non-motor symptoms, most prominently fatigue depressive symptoms being significant predictors ( <...
Abstract Accelerometry enables passive, continuous, high-frequency monitoring under free-living conditions. For individuals with isolated REM sleep behavior disorder (iRBD), a potential prodromal phase of Parkinson’s disease (PD) and dementia Lewy bodies, accelerometry has been primarily applied to aid diagnosis assess phenoconversion risk. To extend this knowledge, we cross-sectionally combined clinical assessments focusing on non-motor symptoms accelerometry-derived features physical...
ABSTRACT Background Isolated REM sleep behavior disorder (iRBD) indicates an early α‐synucleinopathy with approximately 90% of individuals pheno‐converting to Parkinson's disease (PD), dementia Lewy bodies (DLB), or multiple system atrophy (MSA). Recently, prodromal definitions (pPD, pDLB, pMSA) have been introduced. Objective To investigate the overlap in established iRBD cohort. Methods We applied current diagnostic criteria for pPD, and pMSA N = 55 from local Results All except two...
Abstract INTRODUCTION In neuropsychological diagnostics, the assignment of cognitive tests to domains is usually not empirically based. Hence, we aimed assess dimensionality structure cognition in individuals with Parkinson's disease (PD) and conceptually replicate findings cognitively healthy (CHIs). METHODS We performed Exploratory Graph Analysis (EGA) for analysis test scores N = 698 PD from DEMPARK/LANDSCAPE study. Redundancy was reduced based on Unique Variable (UVA) before...
Contralesional 1-Hz repetitive transcranial magnetic stimulation (rTMS) over the right pars triangularis combined with speech-language therapy (SLT) has shown positive results on recovery of naming in subacute (5-45 days) post-stroke aphasia. NORTHSTAR-CA is an extension previously reported NORTHSTAR trial to chronic aphasia (>6 months post-stroke) designed compare effectiveness same rTMS protocol both phases.
Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) cohorts have provided insights into the earliest neurodegenerative processes in α‐synucleinopathies. Even though polysomnography (PSG) remains gold standard for diagnosis, an accurate questionnaire‐based algorithm to identify eligible subjects could facilitate efficient recruitment research. Objective This study aimed optimize identification of with iRBD from general population. Methods Between June 2020 and...
Abstract Background Isolated REM sleep behavior disorder (iRBD) is an early α-synucleinopathy often accompanied by incipient cognitive impairment. As executive dysfunctions predict earlier phenotypic conversion from iRBD to Parkinson’s disease and Lewy body dementia, training focusing on functions could have disease-modifying effects for individuals with iRBD. Methods The study CogTrAiL-RBD investigates the short- long-term effectiveness feasibility underlying neural mechanisms of a...
The most frequently used instrument to assess health-related quality of life (HrQoL) in Parkinson's disease (PD) is the Disease Questionnaire 39 (PDQ-39). However, both dimensionality eight PDQ-39 subscales and their summary score recently faced criticism. Furthermore, data on disease-related neuropsychological determinants role gender HrQoL PD are inconclusive yet. Therefore, our aim was reevaluate structure further explore PD. 245 patients (age: M = 69.64, SD 8.43; 62.9% male; H&Y: Md...
Abstract Background Cognitive reserve (CR) is considered a protective factor for cognitive function and may explain interindividual differences of performance given similar levels neurodegeneration, e.g., in Alzheimer´s disease. Recent evidence suggests that CR also relevant Parkinson’s disease (PD). Objective We aimed to explore the role life-stage specific overall cognition domains cross-sectionally longitudinally PD. Methods The cross-sectional analysis with data from DEMPARK/LANDSCAPE...
Abstract Background Mild cognitive impairment (MCI) involves decline beyond typical age-related changes, but without significant daily activity disruption. It can encompass various domains as the causes of MCI are diverse. well frequent comorbid neuropsychiatric conditions like depression and anxiety affect individuals’ quality life. Early interventions essential, computerized training (cCT) is an established treatment method. This paper presents protocol for NeuroNation MED Effectiveness...
Meta-analyses have demonstrated cognitive training (CT) benefits in Parkinson's disease (PD) patients. However, the patients' status has only rarely been based on established criteria. Also, prediction analyses of CT success sparsely conducted.To determine effects PD patients with mild impairment (PD-MCI) and noncognitive outcomes compared to an active control group (CG) analyze predictors.Sixty-four PD-MCI (age: 67.61 ± 7.70; UPDRS-III: 26.58 13.54; MoCA: 24.47 2.78) were randomized either...
Meta-analyses indicate positive effects of cognitive training (CT) in patients with Parkinson's disease (PD), however, most previous studies had small sample sizes and did not evaluate long-term follow-up. Therefore, a multicenter randomized controlled, single-blinded trial (Train-ParC study) was conducted to examine CT PD mild impairment (PD-MCI). Immediately after CT, an enhancement executive functions demonstrated. Here, we present the results 6 12 months CT.At baseline, 64 PD-MCI were...
Objective: Depressive symptoms have a high prevalence in patients with Parkinson's disease (PD) and are associated cognitive dysfunction. Especially PD mild impairment (MCI), time-efficient valid instrument for the assessment of depression primarily focusing on psychological disregarding confounding somatic is needed. We performed an examination psychometric properties Beck Depression Inventory II (BDI-II) Fast Screen (BDI-FS). Methods: The sample consisted 64 [22 females 42 males, mean age:...
Background: Music-assisted treadmill training (MATT) is a new therapy approach for Parkinson's disease (PD) patients, combining with rhythmic auditory cueing and visual feedback. PD studies have shown larger positive effects on motor outcomes than usual training. However, cognition, in contrast, are less clear. Existing provided intensive protocols included only stable medicated patients. Thus, pilot randomized controlled trial (RCT) was designed to analyze the feasibility of shorter...
Abstract Background Subjective cognitive decline (SCD) may occur very early in the course of Parkinson’s disease (PD) before onset objective decline. Data on neural correlates and determinants SCD PD are rare. Objective The aim present study was to identify as well sociodemographic, clinical, neuropsychological predictors patients with PD. Methods We retrospectively analyzed 30 without impairment (23% female, 66.90 ± 7.20 years, UPDRS-III: 19.83 9.29), which n = 12 were classified having no...
Cognitive integrity is a fundamental driver of health. The exact structure strategies against cognitive impairment still under debate.To compare the short-term effects multicomponent training (BrainProtect) with those general health counseling (GHC) on abilities and health-related quality life (HRQoL) in healthy adults Germany.In this parallel randomized controlled trial (RCT), 132 eligible cognitively (age ≥50 years, Beck Depression Inventory ≤9/63; Montreal Assessment ≥26/30) were to...
Background: Age-related neuronal changes impact cognitive integrity, which is a major contributor to health and quality of life. The best strategy prevent decline Alzheimer’s disease still debated. Objective: To investigate the long-term effects eight-week multicomponent training program BrainProtect ® on abilities compared general counseling (GHC) in cognitively healthy adults Germany. Methods: Healthy (age ≥50 years) previously randomized either GHC ( n = 72) or (intervention group, IG,...
Abstract Even after a long time of research on dual-tasking, the question whether two tasks are always processed serially (response selection bottleneck models, RSB) or also in parallel (capacity-sharing models) is still going on. The first models postulate that central processing stages cannot overlap, producing Task 2. second class posits cognitive resources shared between tasks, allowing for processing. In series three experiments, we aimed at inducing vs. serial by manipulating relative...
Background: Cognitive impairment is a very frequent and severe nonmotor symptom of Parkinson’s disease (PD). Early intervention in this at-risk group for cognitive decline may be crucial long-term preservation functions. Computerized working memory training (WMT) has been proven beneficial non-PD patient populations, but such evidence still needed patients with PD. Objective: This study aimed to evaluate the effect WMT on visuo-spatial (WM) cognitively unimpaired Methods: A single-blind...