A5090572957- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Botulinum Toxin and Related Neurological Disorders
- Cerebral Palsy and Movement Disorders
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Balance, Gait, and Falls Prevention
- Multiple Sclerosis Research Studies
- Prosthetics and Rehabilitation Robotics
- Neurological disorders and treatments
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Glycogen Storage Diseases and Myoclonus
- Tactile and Sensory Interactions
- Autoimmune and Inflammatory Disorders Research
- Genetic Neurodegenerative Diseases
- Muscle Physiology and Disorders
- Motor Control and Adaptation
- Parkinson's Disease and Spinal Disorders
- Advanced Neuroimaging Techniques and Applications
- Lower Extremity Biomechanics and Pathologies
- Cancer Treatment and Pharmacology
- Vestibular and auditory disorders
Azienda Ospedaliera Universitaria Pisana
2015-2024
University of Pisa
2012-2024
Ospedale Cisanello
2011-2012
This paper presents a novel electromyography (EMG)-driven hand exoskeleton for bilateral rehabilitation of grasping in stroke. The developed was designed with two distinctive features: (a) kinematics intrinsic adaptability to patient's size, and (b) free-palm free-fingertip design, preserving the residual sensory perceptual capability touch during assistance real objects. In envisaged training strategy, non paretic acted as guidance tasks. Grasping force exerted by estimated real-time from...
This paper proposes a new multimodal architecture for gaze-independent brain-computer interface (BCI)-driven control of robotic upper limb exoskeleton stroke rehabilitation to provide active assistance in the execution reaching tasks real setting scenario. At level action plan, patient's intention is decoded by means an vision system, through combination Kinect-based which can online robustly identify and track 3-D objects, eye-tracking system objects selection. generation, BCI used move...
In lower mammals, locomotion seems to be mainly regulated by subcortical and spinal networks. On the contrary, recent evidence suggests that in humans motor cortex is also significantly engaged during complex tasks. However, a detailed understanding of cortical contribution still lacking especially stereotyped activities. Here, we show areas finely control leg muscle activation treadmill walking. Using novel technique based on combination Reliable Independent Component Analysis, source...
This study, conducted in a group of nine chronic patients with right-side hemiparesis after stroke, investigated the effects robotic-assisted rehabilitation training an upper limb robotic exoskeleton for restoration motor function spatial reaching movements. The assisted was administered period 6 weeks including and antigravity To assess carry-over observed improvements movement during into improved function, kinesiologic assessment performed by means motion dynamic electromyographic...
Objective. Mobile Brain/Body Imaging (MoBI) frameworks allowed the research community to find evidence of cortical involvement at walking initiation and during locomotion. However, decoding gait patterns from brain signals remains an open challenge. The aim this work is propose validate a deep learning model decode phases Electroenchephalography (EEG). Approach. A Long-Short Term Memory (LSTM) neural network has been trained deal with time-dependent information within EEG have preprocessed...
Background: Gait and mobility impairments are common in progressive multiple sclerosis (MS), leading to reduced quality of life (QoL). Objective: In this randomized controlled study, we tested the effects robot-assisted gait training (RAGT) compared it conventional physiotherapy, measuring walking ability, depression, fatigue, QoL patients with MS severe disability. Methods: Fifty-two participants (Expanded Disability Status Scale score 6–7) completed study protocol. They received two...
A brain injury resulting from unilateral stroke critically alters functionality and the complex balance within cortical activity. Such modifications may depend on lesion location involvement. Indeed, recent findings pointed out necessity of applying a stratification based when investigating inter-hemispheric in stroke. Here, we tested whether involvement could imply differences band-specific activity symmetry post patients with cortico-subcortical subcortical strokes. We explored related to...
In this paper we propose a full upper limb exoskeleton for motor rehabilitation of reaching, grasping and releasing in post-stroke patients. The presented system takes into account the hand pre-shaping object affordability it is driven by patient's intentional control through self-paced asynchronous Motor Imagery based Brain Computer Interface (MI-BCI). developed antropomorphic eight DoFs (two hand, two wrist four arm) allows support manipulation activity at level single joint. study, show...
Up to now, the mechanism of motor impairment and recovery after stroke has been thought be based on interhemispheric competition model. According this model, which assumes that suppressing excitability contralesional hemisphere will enhance by reducing transcallosal inhibition (TCI) hemisphere, many clinical trials used non-invasive brain stimulation improve function. Despite some positive findings, meta-analysis shows an important source variability in results, questioning whether model...
What determines motor recovery in stroke is still unknown and finding markers that could predict improve a challenge. In this study, we aimed at understanding the neural mechanisms of function after using neurophysiological by means cortical excitability (Transcranial Magnetic Stimulation – TMS) brain oscillations (electroencephalography EEG). cross-sectional fifty-five subjects with chronic (62±14 yo, 17 women, 32±42 months post-stroke) were recruited two sites. We analyzed TMS measures...
Background. Neurorehabilitation protocols based on the use of robotic devices have recently shown to provide promising clinical results. However, their efficacy is still limited because poor comprehension mechanisms at basis functional enhancements. Objective. To increase basic understanding robot-mediated neurorehabilitation by performing experiments a rodent model stroke. Methods. Mice were trained pull back handle platform and performances in task evaluated before after focal cortical...
Despite the advances in field of brain computer interfaces (BCI), use sole electroencephalography (EEG) signal to control walking rehabilitation devices is currently not viable clinical settings, due its unreliability. Hybrid (hHMIs) represent a very recent solution enhance performance single-signal approaches. These are classification approaches that combine multiple human-machine interfaces, normally including at least one BCI with other biosignals, such as electromyography (EMG). However,...
Several training programs have been developed in the past to restore motor functions after stroke. Their efficacy strongly relies on possibility assess individual levels of impairment and recovery rate. However, commonly used clinical scales rely mainly subjective functional assessments are not able provide a complete description patients' neuro-biomechanical status. Therefore, current tests should be integrated with specific physiological measurements, i.e. kinematic, muscular, brain...
Abstract Background Although robotics assisted rehabilitation has proven to be effective in stroke rehabilitation, a limited functional improvements Activities of Daily Life been also observed after the administration robotic training. To this aim study we compare efficacy terms both clinical and outcomes training performed with multi-joint exoskeleton goal-oriented exercises compared conventional physical therapy program, equally matched intensity time. As secondary goal study, it was...
INTRODUCTION: There is growing evidence on the efficacy of gait robotic rehabilitation in patients with multiple sclerosis (MS), but most studies have focused parameters. Moreover, clear indications clinical use robotics still lack. As part CICERONE Italian Consensus Robotic Rehabilitation, aim this systematic review was to investigate existing concerning role lower limb improving functional recovery MS.EVIDENCE ACQUISITION: We searched for and systematically reviewed evidence-based MS,...
Gait impairment, balance problems and falls have a negative impact on independence in ADL quality of life patients affected by Hereditary Spastic Paraplegia (HSP). Since no pharmacological options are available, treatments rely mostly rehabilitation therapy, although almost data this topic exist. Given the demonstrated effectiveness robotics improving gait various neurological diseases, aim study is to test robotic-aided program training balance, walking ability adult subjects uncomplicated...
Early management of spasticity may improve stroke outcome. Botulinum toxin type A (BoNT-A) is recommended treatment for post-stroke (PSS). However, it usually administered in the chronic phase stroke. Our aim was to determine whether length time between onset and initial BoNT-A injection has an effect on outcomes after PSS treatment. This multicenter, longitudinal, cohort study included patients (time since <12 months) with who received first according routine practice. The main outcome...
Exercise is well tolerated and induces relevant improvements in physical mental functioning of persons with Multiple Sclerosis (MS). Unfortunately, due to the wide variety symptoms broad range exercise interventions, it not possible make unified recommendation as what type safe effective for MS.The aim was test impact an intensive task-oriented training on motor function quality life 17 MS patients Expanded Disability Status Scale (EDSS) between 4 5.5.Patients underwent a two-week intensive,...