A5051387686- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- IgG4-Related and Inflammatory Diseases
- Cancer Genomics and Diagnostics
- Biliary and Gastrointestinal Fistulas
- Genetic factors in colorectal cancer
- Dysphagia Assessment and Management
- Neuroblastoma Research and Treatments
- Complement system in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease and Transplantation
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
Fukushima Medical University
2016-2025
Fukushima Medical University Hospital
2014-2024
National Institutes of Health
2020
Yale University
2020
Harvard University
2020
Rockefeller University
2020
Brigham and Women's Hospital
2020
Federation of American Societies for Experimental Biology
2020
University Gastroenterology
2018
Fukushima University
2018
Background: This study aimed to perform a comprehensive gene expression analysis in patients with early-stage gastric cancer (EGC) identify profiles specific (GC) lesions. Methods: Biopsy specimens were collected from one EGC lesion and three background mucosal areas of scheduled for endoscopic submucosal dissection (ESD). Lesion-specific these four biopsies analyzed using DNA microarrays. Patients concurrent EGCs at the time an ESD or history GC classified into multiple group (n = 26),...
As gemcitabine is a key anti-tumor agent for unresectable pancreatic ductal adenocarcinoma (PDAC), it important to predict the outcomes of chemotherapy. The present study aimed confirm whether derived neutrophil‑to‑lymphocyte ratio (dNLR) able chemotherapy outcomes. To elucidate role dNLR in patients that underwent chemotherapy, current evaluated clinicopathological variables 31 with PDAC treated gemcitabine. correlation between variables, and progression‑free survival (PFS) overall (OS)...
The complement system, a part of the innate immune can be activated via three different pathways. In alternative pathway, factor D (FD) plays essential roles in both initiation and amplification loop circulates as an active form. Mannose-binding lectin-associated serine proteases (MASPs) are key enzymes lectin MASP-1 and/or MASP-3 reported to involved activation FD. current study, we generated mice monospecifically deficient for or found that sera MASP-1-deficient lacked pathway activity,...
Endoscopic ultrasound‑guided biliary drainage (EUS‑BD) is performed as a second method when endoscopic retrograde cholangiopancreatography‑guided fails. There are several severe adverse events in EUS‑BD, and avoiding technical failure desirable. Although EUS‑BD skilled treatment, the appropriate conditions for beginners not well known. The present study aimed to clarify cases beginners. retrospective cohort included patients with malignant obstruction who underwent which was by between March...
Abstract Background The prognosis of pancreatic cancer (PC) has been improved by new chemotherapy regimens (combination 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin (FOLFIRINOX) or gemcitabine plus nab-paclitaxel (GnP)). Unfortunately, chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse event these two regimens. efficacy pregabalin for CIPN reported in previous studies. However, the mirogabalin remains unknown. Thus, this study, we aimed to clarify which drug...
Fixation of an esophageal self-expandable metal stent (SEMS) with over-the-scope-clip (OTSC) system for a benign stricture to prevent migration has been reported. However, the efficacy SEMS fixation OTSC malignant remains unclear. The aim this retrospective study was evaluate feasibility stricture.Twelve patients who underwent placement and were included in study. primary endpoint technical success. secondary clinical success, which defined as improvement at least 1 grade dysphagia score...
Abstract Background The efficacy of immune checkpoint blockade in the treatment microsatellite instability (MSI)-high tumors was recently reported. Therefore, acquisition histological specimens is desired cases unresectable solid pancreatic lesions (UR SPLs). This study investigated endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for UR SPL tissue and MSI evaluation. Methods A total 195 patients who underwent EUS-guided aspiration (EUS-FNA) or EUS-FNB...
We aimed to clarify the role of complement C3a and its receptor C3aR in progression pancreatic ductal adenocarcinoma (PDAC).We evaluated serum levels C3 patients with PDAC. expression tissue was assessed using a microarray. To confirm protumoral effects PDAC, we conducted vitro experiments PDAC cell lines (Panc-1 MiaPaca-2) that exhibit high expression.Serum both were higher 26 than 28 nontumor-bearing controls. In microarray, observed increased cells, especially cases metastatic lesions....
Background and study aims The safety efficacy of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in very elderly patients remains unclear. aim this was to evaluate the ESD EGC age 85 years older. Patients methods who underwent between September 2003 April 2015 were divided into 3 groups: (≥ years; 43 patients), (65 - 84 511 non-elderly ( ≤ 64 161 patients). Adverse events (AEs) used as primary endpoint assess ESD, treatment outcomes (i. e., en bloc resection rate,...
To investigate the location to which a pancreatic stent should be inserted prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).Over ten-year period at our hospital, 296 patients underwent their first ERCP procedure and had inserted; this study included 147 who performed primarily for biliary investigation PEP. We divided these into two groups: 131 with head (head group) 16 up body or tail (body/tail group). Patient characteristics factors were compared...
Schwannomas are difficult to diagnose using imaging alone. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is an effective and safe tissue sampling technique. Nevertheless, few reports have described EUS-FNA for schwannoma.This study evaluates the efficacy of diagnosing retrospective examined six consecutive schwannoma patients who were diagnosed as having either from results or surgically resected specimens. The primary endpoint was diagnostic accuracy schwannoma. secondary...
The aim of this study was to review the efficacy contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) in diagnosing gallbladder (GB)-protruded lesions. Thirty-eight patients underwent CH-EUS for diagnosis GB-protruded Twenty-four whose major axes their largest lesions were longer than 10 mm recruited. ability diagnose malignant or benign reviewed. We treated with brindled enhanced patterns as and those uniformly unenhanced benign. Furthermore, three gastroenterologists who not...
Objectives The aim of this study was to review the suitability endoscopic ultrasonography‐guided fine needle aspiration (EUS‐FNA) for ruling out malignancy in autoimmune pancreatitis patients. Methods We retrospectively reviewed 40 patients (type 1:37 patients; type 2: two possible pancreatitis: one patient) who received EUS‐FNA. Among patients, 34 were not histopathologically diagnosed with by EUS‐FNA, and they followed up more than 6 months our hospital. Moreover, 14 pancreatic cancer...
Autoimmune pancreatitis (AIP) is treatable with steroids, but relapse frequent. The efficacy of steroid pulse therapy has been shown for various autoimmune diseases, not become established therapy. In this study, we reviewed the in 24 subjects who were diagnosed AIP type 1 at our hospital. Patient characteristics, time-course serum IgG4, and cumulative relapse-free survival rate compared between patients received oral (oral group) those treated (pulse group). Serum IgG4 was reduced...
Objective: The efficacy of sedation during endoscopic injection sclerotherapy (EIS) for esophageal varices (EVs) in patients with liver cirrhosis remains unclear. aim this study is to compare the and safety between propofol- midazolam-based EIS.
Pancreatic stents to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis
A 63-year-old woman was referred to Fukushima Red Cross Hospital with an enlargement of the left submandibular gland and subcutaneous bleeding in chest legs. diffuse pancreas also detected by abdominal computed tomography, laboratory data showed severe thrombocytopenia. She diagnosed IgG4-related disease (IgG4-RD) complicated autoimmune thrombocytopenia treated methylprednisolone, after which number platelets favorably increased. Further investigation for liver dysfunction revealed...
Other than surgery, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the only procedure for histologically diagnosing autoimmune pancreatitis (AIP). However, adequate specimens are difficult to obtain. Recently, more were reported be obtained with EUS-FNA a wet suction technique (WEST) conventional EUS-FNA.To diagnose AIP by WEST.Eleven patients possible type 1 between February 2016 and August 2018 underwent WEST (WEST group), four punctures 19 or 22 G needles. As historical...
Proper sedation is necessary for the safe and satisfactory completion of endoscopic submucosal dissection (ESD) early gastric cancer. This study was conducted as a comparative trial efficacy safety, comparing propofol-based midazolam-based during ESD cancer patients.This examined 64 lesions in 58 patients treated using with midazolam plus pentazocine between July 2013 January 2014 (group M) 237 216 by propofol February December 2015 P). The two groups were compared terms frequency body...
Predicting the prognosis of unresectable pancreatic ductal adenocarcinoma (PDAC) is useful in determining appropriate management strategy. The present study aimed to investigate association between PDAC and inflammation‑based markers, such as neutrophil‑to‑lymphocyte ratio (NLR), platelet‑to‑lymphocyte ratio, prognostic nutritional index, modified Glasgow score (mGPS) controlling status score. A total 72 patients with who received chemotherapy were included. Inflammation‑based markers...
Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary cases unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for MSI evaluation patients with UR-PC.A total 89 UR-PC who underwent aspiration (EUS-FNA) or EUS-FNB 22-G needles at...
We investigated the factors predictive of failure when placing multiple endoscopic selfexpandable metallic stents (SEMSs) to relieve a malignant biliary obstruction.The angle between target duct stricture and first implanted SEMS was significantly higher in than success group.There were fewer wire or dilation devices passing cell group group.The smaller patients with cell.In conclusion, large identified as factor for stent-in-stent placement.