A5102022639- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Autoimmune and Inflammatory Disorders Research
- Pulmonary Hypertension Research and Treatments
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Liver physiology and pathology
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Peripheral Neuropathies and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vasculitis and related conditions
- Nitric Oxide and Endothelin Effects
- Gastrointestinal Tumor Research and Treatment
- Eicosanoids and Hypertension Pharmacology
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Diabetes and associated disorders
- Chronic Lymphocytic Leukemia Research
- Inflammatory mediators and NSAID effects
- Hair Growth and Disorders
Tokushima Red Cross Hospital
2004-2024
Showa University
1995-2008
Fukushima Medical University
1995-2001
Imperial Household Agency
1993-1998
Objective To compare the efficacy and safety between tocilizumab added to methotrexate switched from in patients with active rheumatoid arthritis (RA). Methods This is a 2-year randomised, controlled study. RA moderate or high disease activity despite were randomly assigned either (add-on) (switch). The primary endpoint was DAS28 remission rate at week 24. Secondary objectives included other clinical indices, radiological outcomes assessed van der Heijde-modified total Sharp scoring system...
Objective To evaluate the sustained remission and low disease activity after discontinuation of tocilizumab in patients with rheumatoid arthritis who were treated alone or combination methotrexate. Methods The SURPRISE study was a 2-year, open-label randomised controlled study. Among had been to additional (ADD-ON) switch (SWITCH) first year, those achieved based on score for 28 joints (DAS28-ESR<2.6) discontinued at week 52 observed following weeks. endpoint second year included...
To investigate the significance of presence or absence thymus in development pulmonary hypertension (PH) following monocrotaline (MCT) administration, degree MCT-induced PH (MCT-PH) athymic nude (F344/N Jcl-rnu) rats was compared with that their euthymic (rnu/+) littermates.Histopathological studies lung terms interstitial edema, congestion, thickening alveolar wall, inflammatory cell infiltration and degeneration arteries were performed by staining hematoxylin-eosin (HE), elastin van Gieson...
Experimental pulmonary hypertension (PH) was induced by a single injection of monocrotaline (MCT), pyrrolizidine alkaloid extracted from Crotalaria spectabilis. The effect beraprost sodium, stable prostacyclin analogue, on the development MCT-induced PH in rats studied. Chronic administration sodium at dose 30 micrograms/kg/day initiated same day as MCT decreased degree determined weight ratio right ventricular free wall to that left ventricle plus septum depending duration administration....
Anticardiolipin antibodies (aCL) were studied in relation to pulmonary hypertension (PH) 22 patients with mixed connective tissue disease (MCTD) or systemic lupus erythematosus (SLE). The mean arterial pressure (mPAP) values similar the 12 MCTD and 10 SLE patients: 26 ± 11 25 mm Hg, respectively. However, frequency of PH was higher (60%) than (33%). titers aCL significantly (38 27 IU/ml) (17 7 IU/ml; p < 0.02). Two high had multiple cerebral infarction transverse myelitis, deep vein...
The applicability of monitoring concentrations serum KL-6 and surfactant protein-D (SP-D) in the detection methotrexate-associated lung injury (MTX pneumonitis) patients with rheumatoid arthritis (RA) was investigated. these markers, sequentially measured two RA complicated MTX pneumonitis, were increased accordance severity pneumonitis. Conversely, markers decreased improvement suggesting that could be applicable not only for detecting onset but also therapeutic response...
Objectives: To validate the usefulness of a hepatic fibrosis scoring system fibrosis-4 (FIB-4) index to diagnose liver diseases in rheumatoid arthritis (RA) patients treated with methotrexate (MTX).Methods: The FIB-4 (age(years) × AST(U/L)/platelet (PLT) (109/L) √ALT(U/L)), proposed as predictor for HIV/HCV coinfection, was evaluated this study. RA on MTX treatment were screened by values detect fibrotic change liver. Liver biopsy specimens examined histologically high values.Results:...
To evaluate the clinical and structural efficacy of tocilizumab (TCZ) during its long-term administration in patients with rheumatoid arthritis (RA).In total, 693 RA who started TCZ therapy were followed for 3 years. Clinical was evaluated by DAS28-ESR Boolean remission rates 544 patients. Joint damage assessed calculating modified total Sharp score (mTSS) 50 patients.When reason discontinuation limited to inadequate response or adverse events, 1-, 2-, 3-year continuation 84.0%, 76.8%,...
A 63-year-old woman was referred to Fukushima Red Cross Hospital with an enlargement of the left submandibular gland and subcutaneous bleeding in chest legs. diffuse pancreas also detected by abdominal computed tomography, laboratory data showed severe thrombocytopenia. She diagnosed IgG4-related disease (IgG4-RD) complicated autoimmune thrombocytopenia treated methylprednisolone, after which number platelets favorably increased. Further investigation for liver dysfunction revealed...
Fibrin glue has been used as a hemostatic and adhesive agent for many years, but its efficacy in digestive surgery is still controversial. In this study, we evaluated the effect of fibrin on healing small large bowel anastomotic portions by measurement bursting pressure. Further, preventing intra-abdominal adhesion formation was assessed. Our results indicated that enhanced resistance towards an elevation intraluminal pressure bowel, not bowel. Concomitantly, did significantly attenuate...
In a 31-year-old Japanese man with cytophagic histiocytic panniculitis (CHP) remission was achieved by combination of combined chemotherapy CHOP and cyclosporin A treatment. He admitted to our hospital in January 1994 recurrent high fever 40.2 degrees C tender violaceous subcutaneous nodules on his trunk, arms legs. developed pancytopenia, hemorrhagic diathesis, liver dysfunction. Histological examination the biopsied nodule revealed lobular fat necrosis massive infiltration histiocytes...
Introduction: Collagen phagocytosis by fibroblasts is involved in the intracellular pathway related to collagen breakdown soft connective tissues. The possible role of lipopolysaccharide (LPS) regulating this fibroblast function has not been elucidated so we investigated effect LPS from Actinobacillus actinomycetemcomitans , a periodontopathic bacterium, on phagocytic activity human gingival and associated regulatory mechanisms. Methods: pretreatment stimulated binding collagen‐coated beads...
A 66-year-old man was referred to our hospital with an increasing subepithelial lesion in the gastric antrum. Using esophagogastroduodenoscopy, a tumor steep, 20-mm-high rise protruding lumen observed. The mucosal surface of reddish, ulcers forming at base. Moreover, mobile and soft. biopsy specimen taken from ulcer, but tissue not collected submucosa. Endoscopic ultrasonography (EUS) showed high echoic mass However, because ulceration red, mesenchymal internal bleeding inferred be lipoma....
A 36-year-old woman with primary biliary cirrhosis (PBC)-CREST (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly and telangiectasia) overlap syndrome complicated by Sjögren's arthritis is reported. She had suffered from sclerodactyly, morning stiffness, arthralgia sicca symptoms since 34 years of age. exhibited an increased level alkaline phosphatase hyperglobulinemia at 2.8 g/dl without any symptoms, histological findings the biopsy specimen liver were consistent...
An 18‐year‐old woman with abdominal pain was diagnosed as having splenic cysts by computed tomography scan. She had high serum levels of CA19‐9 (2886.8 U/mL; normal value, <35 U/mL), CA125 (131.1 U/mL) and soluble IL‐2 receptor (1490 range, 220–530 U/mL). The resected spleen weighed 1050 g, 14 × 28 cm, more than 10 macroscopic up to 10.3 9.5 cm. There were numerous microscopic in the several on capsule. cyst fluid 2 165 550 U/mL 160 400 U/mL, respectively. After surgery, tumor markers...
The initial presentation of a patient with Wegener's granulomatosis was indistinguishable from that Henoch-Schönlein purpura. presented skin purpura and pulmonary hemorrhage followed by in the colon. diagnosis this at time With time, massive lesions sinus those cavities lung became apparent, specimen obtained lesion disclosed to be granulomatous inflammation. Retrospectively, proteinase 3 antineutrophil cytoplasmic antibody turned out strongly positive her stored serum presentation.(Internal...
<h3>Background</h3> The SURPRISE study is an open-label trial comparing the strategy of tocilizumab (TCZ) plus methotrexate (MTX) (ADD-ON) with switching to TCZ (SWITCH) in Japanese rheumatoid arthritis (RA) patients inadequate response MTX (MTX-IR). Interim 24-wk data showed ADD-ON be superior SWITCH efficacy as assessed using DAS28 remission criteria. Longer-term including radiographic effect are needed assess 2 strategies over time. <h3>Objectives</h3> To 52-wk and safety a TCZ-based...
Introduction: Chronic liver damage from methotrexate (MTX) is not uncommon, and fatal outcome rare. We experienced a case of hepatic failure leading to death. considered the cause death through this proposed method prevent progression injury. Patient concerns: report patient with rheumatoid arthritis treated MTX for 15 years. Diagnosis, interventions, outcomes: A biopsy revealed histological changes similar those advanced nonalcoholic steatohepatitis (NASH), most likely induced by MTX. was...