A5100694708- Cancer survivorship and care
- Cancer Risks and Factors
- Digital Communication and Language
- Allelopathy and phytotoxic interactions
- Health and Wellbeing Research
- Breast Cancer Treatment Studies
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Respiratory viral infections research
- Voice and Speech Disorders
- Lymphatic System and Diseases
- Inhalation and Respiratory Drug Delivery
- HER2/EGFR in Cancer Research
- Physical Activity and Health
- Fungal Infections and Studies
- Cancer Immunotherapy and Biomarkers
- Pneumonia and Respiratory Infections
- Plant Parasitism and Resistance
- Nail Diseases and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Phytoestrogen effects and research
- Plant Pathogens and Fungal Diseases
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Radiation Dose and Imaging
Okayama University Hospital
2019-2024
Okayama University
2019-2024
Okayama Shoka University
2020
Shizuoka City Hospital
2014-2019
Izumi City General Hospital
2016
Tokyo Women's Medical University Adachi Medical Center
2013-2014
Tokyo University of Agriculture and Technology
2012
Waseda University
2012
Kyoto University
1991-2010
Hokkaido University
2010
Abstract We conducted a population‐based prospective cohort study in Japan to examine the relationship between body mass index (BMI) and risk of incidence any cancer at individual sites. Body was calculated from self‐administered weight height baseline. Relative risks (RR) 95% confidence intervals (CI) were multivariate proportional‐hazards models. Among 27,539 persons (15,054 women 12,485 men) aged 40 years or older who free enrollment 1984, 1,672 (668 1,004 developed during 9 follow‐up. In...
Rationale: Matrix metalloprotease (MMP)-9 is an elastolytic endopeptidase produced by activated macrophages that may be involved in the development of human pulmonary emphysema and could inhibited with existing compounds. Mouse models have demonstrated excess MMP-9 production can result permanent alveolar destruction.Objectives: To determine if causes cigarette smoke–induced using knockout mice samples.Methods: lungs were analyzed for inflammation airspace enlargement a mainstream...
Abstract We made detailed research for relationships among physical condition, self‐efficacy and psychological adjustment of patients with advanced cancer in Japan. The sample consisted 85 (42 males 43 females) patients. Interviews were conducted some measurement scales including the Self‐efficacy scale Advanced Cancer (SEAC), Hospital Anxiety Depression Scale (HADS). Karnofsky Performance Status (KPS) medication status also recorded from evaluation by physicians. used structural equation...
BACKGROUND: The relation between body mass index (BMI) and mortality is not well established. objective of this study was to examine the association in Japanese adults.METHODS: In 1990, 18,740 men 20,870 women Miyagi Prefecture rural northern Japan (40-64 years age) completed a self-administered questionnaire including height weight. Cox regression used estimate relative risk (RR) according levels BMI, with adjustment for age, marital status, smoking, drinking, walking, weight change since...
The findings of this study revealed a 22% prevalence Streptococcus pneumoniae among healthy children in Japan; the tended to increase with age. We identified attendance at day-care facilities and presence older siblings as major risk factors associated pneumococcal carriage. A significant decrease colonization was observed during summer; however, seasonal variation independent various factors. Our suggest that prior immunization heptavalent conjugate vaccine within current recommended...
To evaluate the clinical and structural efficacy of tocilizumab (TCZ) during its long-term administration in patients with rheumatoid arthritis (RA).In total, 693 RA who started TCZ therapy were followed for 3 years. Clinical was evaluated by DAS28-ESR Boolean remission rates 544 patients. Joint damage assessed calculating modified total Sharp score (mTSS) 50 patients.When reason discontinuation limited to inadequate response or adverse events, 1-, 2-, 3-year continuation 84.0%, 76.8%,...
Angiosarcoma of the breast is very rare and can be divided into primary secondary angiosarcoma. Radiation-induced angiosarcoma (RIAS) classified as Diagnosis RIAS difficult due to its rarity, interpretation pathological imaging complicated. In National Comprehensive Care Network (NCCN) guidelines, first choice treatment surgery with negative margins. Adjuvant radiotherapy (RT) for close soft tissue margins should considered. Preoperative or adjuvant chemotherapy nonmetastatic disease not...
Abstract Purpose Metformin has been suggested to possibly reduce cancer risk. However, the mechanism underlying positive effects of metformin on treatment remains unclear. We conducted a prospective study evaluate preoperative in patients with early breast cancer. Method evaluated immunological factors (TILs, CD4 + , CD8 PD-L1, IFNγ and IL-2) by comparing core needle biopsies (CNB) obtained before surgical specimens. Seventeen were enrolled this from January December 2016. also analyzed 59...
Plant biodiversity has been studied to explore allelopathic species for the sustainable management of weeds reduce reliance on synthetic herbicides. Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.), was found have plant growth-inhibitory effects, and carnosic acid reported as an allelochemical in plant. In this study, effects seasonal variation (2011−2012) concentration phytotoxicity rosemary leaves from two locations Tunisia (Fahs Matmata) were investigated. The determined...
Trastuzumab-emtansine (T-DM1) is a therapeutic agent molecularly targeting human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC), and it especially effective for MBC with resistance to trastuzumab. Although several reports have described T-DM1 resistance, few examined the mechanism underlying after development of acquired We previously reported that YES1, member Src family, plays an important role in trastuzumab HER2-amplified cells. newly established...
The nitration of tyrosine has been suggested to play a role in the pathogenesis neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's (AD).In present study, we identified four targets protein nitration, T-complex polypeptide 1 alpha subunit (TCP-1), neurofilament L (NFL), glial fibrillary acidic (GFAP) clathrin heavy chain (CHC), normal rat cortex using proteomics approach.There have no reports on these proteins being by nitrated...
Plants produce several chemically diverse bioactive substances that may influence the growth and development of other organisms when released into environment in a phenomenon called allelopathy. Several these allelopathic species also have reported medicinal properties. In this study, potential effects more than hundred plants from Cambodia were tested using dish pack method. The bioassay method specifically targets volatile allelochemicals. Twenty-five found to significant inhibitory on...
Pharmaceutical plants contain several phytochemicals that are sources of myriad biological activities. These activities can be explored in multiple fields for the benefit mankind. with high ethnobotanical indices (i.e., use value and relative frequency citation) were reported potential to inhibit lettuce elongation through leachates volatiles. The focus study was assess Chinese pharmaceutical both antioxidants, as well allelopathic potentials explore any underlying relationship. estimation...
In order to elucidate the antitumor effect and mechanism of action photodynamic therapy (PDT) using photosensitizing agent mono-L-aspartyl chlorin e6 (NPe6) a semiconductor laser, we conducted morphologic study on uterine cervical cancer cell lines. First, tumor shrinkage was confirmed in growth inhibition test. Next, changes after PDT were examined, since major change appeared be necrosis secondary obstruction blood vessels around tumor, an NPe6 uptake experiment performed. The results that...
We report a case of kerion celsi due to Trichophyton tonsurans. An 18-year-old male student judo practitioner had alopecic patches, black dots and subcutaneous abscesses on the right temporal region. The damaged hair represented endothrix infection with T. tonsurans, as assessed by mycological examinations. He was treated oral itraconazole without any therapeutic effect, followed terbinafine good effect. A skin biopsy showed neutrophil, lymphocyte histiocyte infiltration into dermis tissue...