A5086156067- Pneumonia and Respiratory Infections
- Air Quality and Health Impacts
- Vehicle emissions and performance
- Gallbladder and Bile Duct Disorders
- Bacterial Infections and Vaccines
- Pancreatic and Hepatic Oncology Research
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Pancreatitis Pathology and Treatment
- Respiratory viral infections research
- Toxic Organic Pollutants Impact
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Microbial infections and disease research
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Energy, Environment, and Transportation Policies
- Endometrial and Cervical Cancer Treatments
- Antimicrobial Resistance in Staphylococcus
- Corneal surgery and disorders
- Management of metastatic bone disease
- Ocular Surface and Contact Lens
Ohta Nishinouchi Hospital
2024-2025
Osaka University
2007-2024
Fukushima Medical University
2022
Society of Environmental Toxicology and Chemistry
2018
University of Tokyo Hospital
2012-2017
The University of Tokyo
2013-2016
NTT Medical Center
2016
Kobe University
2009-2014
University of California, Davis
2001-2013
Kanagawa Dental University
2008-2009
Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed establish simple score model (SuPER model: Support Reduction) that can applied Methods: This multicenter study enrolled 2074 patients who underwent Among them, 1037 each were randomly assigned the development validation cohorts. In cohort, was established via...
Clinical isolates of Haemophilus influenzae from Japan (n = 296) and the United States 100) were tested by microdilution method for susceptibility in vitro to 10 beta-lactam antibiotics molecular mechanisms resistance. For all isolates, PCR was used identify six elements, including beta-lactamase-producing ampicillin (AMP)-resistance (BLPAR) beta-lactamase-nonproducing AMP-resistance (BLNAR) genes as follows: (1) TEM-1 type beta-lactamase gene, (2) ROB-1 (3) part normal ftsI gene encoding...
ABSTRACT A total of 395 Haemophilus influenzae strains from 226 Japanese institutions participating in the Nationwide Surveillance Study Group for Bacterial Meningitis were received 1999 to 2002. All analyzed by PCR identify resistance genes, and their susceptibilities β-lactam agents determined. Of these strains, 29.1% β-lactamase nonproducing ampicillin (AMP) susceptible (BLNAS) lacked all genes; 15.4% producing AMP resistant had bla TEM-1 gene; 30.6% (low-BLNAR) a Lys-526 or His-517 amino...
A total of 195 Mycoplasma pneumoniae strains were isolated from 2,462 clinical specimens collected between April 2002 and March 2004 pediatric outpatients with respiratory tract infections. Susceptibilities to six macrolide antibiotics (ML), telithromycin, minocycline, levofloxacin, sitafloxacin determined by the microdilution method using PPLO broth. 183 M. isolates susceptible all agents had excellent MIC90s in following order: 0.00195 microg/ml for azithromycin 0.0078 clarithromycin,...
The number of heavy-duty vehicles using alternative fuels such as compressed natural gas (CNG) and new low-sulfur diesel fuel formulations equipped with after-treatment devices are projected to increase. However, few peer-reviewed studies have characterized the emissions particulate matter (PM) other toxic compounds from these vehicles. In this study, chemical biological analyses were used characterize identifiable air pollutants emitted both CNG low-sulfur-diesel-fueled transit buses tested...
Tight junctions (TJs) and adherens (AJs) are major junctional apparatuses in epithelial cells. Claudins adhesion molecules (JAMs) cell (CAMs) at TJs, whereas cadherins nectins CAMs AJs. JAMs associated with ZO proteins, beta- alpha-catenins, afadin. We previously showed that first form cell-cell adhesions where the cadherin-catenin complex is recruited to AJs, followed by recruitment of JAM-ZO claudin-ZO complexes apical side AJs TJs. It not fully understood how TJ components studied roles...
ABSTRACT In this study, real-time PCR with pathogen-specific molecular beacons (MB) and primers was evaluated for prediction of community-acquired pneumonia (CAP) causative agents, detecting six main CAP Streptococcus pneumoniae , Haemophilus influenzae Mycoplasma Chlamydophila Legionella pneumophila pyogenes simultaneously. The assay fresh clinical specimens from infants children ( n = 389) adults 40). MB probes are both pathogen specific, namely, the lytA gene S. mip L. 16S rRNA genes...
The antibiotic susceptibilities, genotypes of penicillin (PEN)-binding protein genes (pbp), and serotype distributions Streptococcus pneumoniae isolates from meningitis patients were investigated by a nationwide surveillance group in Japan between 1999 2002. We analyzed 146 children (</=17 years old) 73 adults (>/=18 old). Isolates with or without abnormal pbp1a, pbp2x, pbp2b identified PCR classified into six genotype patterns 90% MIC (MIC(90)) values for PEN: (i) strains three normal...
Laminins are the major cell-adhesive proteins in basement membrane, consisting of three subunits termed alpha, beta, and gamma. The putative binding site for integrins has been mapped to G domain alpha chain, although trimerization with beta gamma chains is necessary exert its integrin activity. mechanism underlying requirement by laminins remains poorly understood. Here, we show that C-terminal region chain involved modulation activity laminins. We found deletion but not two amino acids...
In total, 24 polycyclic aromatic hydrocarbons (PAHs) in both gas and particle phases 35 nitro-PAHs phase were analyzed the exhaust from heavy-duty diesel vehicles equipped with after-treatment for particulate matter (PM) NOX control. The test carried out using a chassis dynamometer under highway cruise, transient Urban Dynamometer Driving Schedule (UDDS), idle operation. efficiently abated more than 90% of total PAHs. Indeed, particle-bound PAHs reduced by >99%, gaseous removed at various...
The present retrospective study aimed to examine the association between expression of long non‑protein‑coding RNAs (lncRNAs) and clinical prognosis in pretreatment formalin-fixed, paraffin-embedded (FFPE) tissue samples cervical squamous cell carcinoma patients that underwent platinum‑based chemoradiation therapy. Between 2001 2013, 49 consecutive with were selected for (median follow‑up period, 44.1 months). possessed an International Federation Gynecology Obstetrics stage IB1/IIA1 (with...
Journal Article The Rat-Bite Fever Spirochete, with Comparative Study of Human, Wild Rat and Field Vole Strains Get access Shigeru Kusama, Kusama Kitasato Institute for Infectious Diseases, Tokyo Search other works by this author on: Oxford Academic PubMed Google Scholar Rokuzo Kobayashi, Kobayashi Katsuya Kasai Volume 24, Issue 4, April 1919, Pages 366–375, https://doi.org/10.1093/infdis/24.4.366 Published: 01 1919 history Received: 09 December 1918
Antibiotic susceptibilities, genes mediating beta-lactam and macrolide resistance, serotypes were analysed for strains of Streptococcus pneumoniae.A total 392 S. pneumoniae isolated from paediatric patients with community-acquired pneumonia between May 2002 2004. All classified into six genotype patterns according to the mutations found in pbp1a, pbp2x pbp2b identified by PCR. These results are represented adding 'g', indicating genotypic identification.Thirty-nine per cent isolates showed...
ABSTRACT The in vitro activity of tebipenem (TBM), a new oral carbapenem antibiotic, against Streptococcus pneumoniae clinical isolates ( n = 202) was compared with those 15 reference agents. were classified into five genotypic classes after PCR identification abnormal pbp1a , pbp2x and pbp2b genes: (i) penicillin-susceptible S. (PSSP) no pbp genes 34; 16.8%), (ii) penicillin-intermediate (gPISP) only an gene [gPISP 2x )] 48; 23.8%), (iii) gPISP 32; 15.8%), (iv) 16; 7.9%), (v)...
This is a retrospective study aimed at clarifying the details of recurrence patterns and sites in patients with cervical cancer treated definitive radiation therapy (RT). Data were analyzed from consecutive patients, admitted to University Tokyo Hospital (Tokyo, Japan) between 2001 2013, who had received RT, or without chemotherapy, for International Federation Gynecology Obstetrics stages IB-IVA cancer. One hundred thirty-seven formed patient cohort. The median follow-up period surviving...
To evaluate the morphological characteristics of posterior corneal regions including keratic precipitates in eyes with cytomegalovirus (CMV) endotheliitis using anterior segment spectral domain optical coherence tomography (SD-OCT).Thirteen 13 patients polymerase chain reaction-proven CMV were included this study. Slit-lamp images and SD-OCT cornea obtained to analyze clinical structures precipitates. Morphological changes throughout course an antiviral treatment also investigated.Anterior...
We developed a real-time PCR to detect Mycoplasma pneumoniae with primer set designed for the 16S rRNA gene. Clinical samples (n=937) were collected from children community-acquired pneumonia between April 2002 and March 2004 at 12 Japanese medical institutions. Sensitivity of was calculated as 10 colony-forming units per reaction tube using pMP01 plasmid carrying 225-bp target DNA fragment gene in M. M129, standard strain. Results, obtained within 2 h, compared those conventional culture...
The purpose of this retrospective study was to assess the efficacy salvage radiation therapy (RT) or chemoradiation (CRT) for locoregional recurrence (LR) esophageal cancer after curative surgery. Forty-two patients who received RT CRT LR surgery between November 2000 and May 2012 were reviewed. intended regimen 60 Gy in 30 fractions combined with concurrent platinum-based chemotherapy. Median follow-up periods 17.9 months all evaluable 28.2 still alive (19 patients) at analysis time. 1-,...
The conjunctival epithelium consists of epithelial cells and goblet derived from stem/progenitor cells. However, the source these is not well known because no specific markers for have been discovered. Therefore, to identify cell markers, we performed single-cell RNA sequencing a population human-induced pluripotent stem (hiPSCs). following were identified: BST2, SLC2A3, AGR2, TMEM54, OLR1, TRIM29. Notably, BST2 was strongly positive in basal epithelium, which thought be rich Moreover, able...