A5103098511- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Central Venous Catheters and Hemodialysis
- Lung Cancer Treatments and Mutations
- Hair Growth and Disorders
- Skin and Cellular Biology Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Venous Thromboembolism Diagnosis and Management
- Folate and B Vitamins Research
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Cardiac Arrhythmias and Treatments
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Pluripotent Stem Cells Research
- Electrodeposition and Electroless Coatings
- Esophageal and GI Pathology
- Advanced NMR Techniques and Applications
- Breast Lesions and Carcinomas
- Laser Material Processing Techniques
- Dialysis and Renal Disease Management
University of Pennsylvania
2007-2021
Hospital of the University of Pennsylvania
2014-2017
Mount Sinai Hospital
2017
Mount Sinai Hospital
2017
NewYork–Presbyterian Hospital
2016
Penn Presbyterian Medical Center
2016
University of Illinois Chicago
2016
Cornell University
2016
Brigham and Women's Hospital
2016
Veterans Health Administration
2016
During early rodent development, the parietal endoderm appears from an inner cell mass and produces large amounts of basement membrane components, such as laminin-1 collagen IV. To elucidate regulatory network for gene expression during these procedures, we constructed a series short interfering RNA vectors targeted to various transcription factors, transfected them into F9 embryonal carcinoma cells, evaluated effects silencing on induction differentiation component production by treating...
Purpose To characterize hepatocellular carcinoma (HCC) cells surviving ischemia with respect to cell cycle kinetics, chemosensitivity, and molecular dependencies that may be exploited potentiate treatment transarterial embolization (TAE). Materials Methods Animal studies were performed according institutionally approved protocols. The growth kinetics of HCC studied in standard ischemic conditions. Viability measured by using flow cytometry. Cytotoxicity profiling was a colorimetric...
The proteasome inhibitor bortezomib was tested in a cell screen as single agent with good efficacy multiple hematologic and solid cancer lines. Phase II/III studies have supported the use of malignancies. In tumors, however, results been poor. There is data that can induce PTEN expression resulting down-regulation PI3K-Akt signaling. We others shown Akt radiation sensitization. therefore evaluated head neck line SQ20B sensitizer. constitutively active mutation EGFR robust response. found 10...
AIMTo assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts (TIPS) and compare outcomes with maximally TIPS. METHODS Polytetrafluoroethylene covered TIPS (Viatorr) fromJuly 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution.Two hundred thirty patients had 10 mm (mTIPS), while 43 who increased risk hepatic encephalopathy (HE), based on clinical evaluation or low pre-TIPS gradient (PSG), 8 (smTIPS).Group...
The cellular response and serum blocking factors of 70 cancer patients were assessed by micro-MLC PHA-stimulation techniques. Serum level carcinoembryonic antigen (CEA) was determined radioimmunoassay, an attempt made to correlate the concentration CEA with inhibitory effect each on blastogenic lymphocytes from healthy subjects. A direct correlation found between activity, extent disease. However, negative sera also inhibited transformation autologous normal homologous lymphocytes. This...
The hair follicle is one of the skin appendages that develops through reciprocal epithelial-mesenchymal interactions. Although a large number studies have been made on mechanisms development, whole molecular mechanism governs development remains poorly defined. To further understand basis it necessary to identify genes drive morphogenesis. As an initial approach, we attempted gene products associated with mouse development. Genes upregulated in vibrissal placodes were screened by polymerase...
In this study, we describe new methods for studying cancer cell metabolism with hyperpolarized 13C magnetic resonance spectroscopy (HP MRS) that will enable quantitative studies at low oxygen concentrations. Cultured hepatocellular carcinoma cells were grown on the surfaces of non-porous microcarriers inside an NMR spectrometer. They perfused radially from a central distributer in modified tube (bioreactor). The level perfusate was continuously monitored and controlled externally....