A5102996973- Physics of Superconductivity and Magnetism
- Neurogenesis and neuroplasticity mechanisms
- Quantum and electron transport phenomena
- Disaster Management and Resilience
- Developmental Biology and Gene Regulation
- Immune Cell Function and Interaction
- Magnetic and transport properties of perovskites and related materials
- Pluripotent Stem Cells Research
- Advanced Chemical Physics Studies
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Rare-earth and actinide compounds
- Mitochondrial Function and Pathology
- Semiconductor Lasers and Optical Devices
- Neuroscience and Neuropharmacology Research
- Thin-Film Transistor Technologies
- Semiconductor materials and devices
- Semiconductor Quantum Structures and Devices
- Wnt/β-catenin signaling in development and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- GaN-based semiconductor devices and materials
- Metabolism and Genetic Disorders
- Cancer Immunotherapy and Biomarkers
- Magnetic confinement fusion research
- Inflammatory Bowel Disease
Tohoku University
2014-2024
Mitsubishi Tanabe Pharma Corporation
2011-2024
KAN Research Institute
2013-2022
Tottori University
2002-2022
Kyoto University
1992-2021
Mitsubishi Group (Japan)
2016-2018
Yokohama National University
2014
Nagoya University
1989-2013
Keio University
2004-2012
Niigata University
2004-2010
Human induced pluripotent stem cells (iPSCs) can provide a promising source of midbrain dopaminergic (DA) neurons for cell replacement therapy Parkinson's disease. However, iPSC-derived donor inevitably contain tumorigenic or inappropriate cells. Here, we show that human DA progenitor be efficiently isolated by sorting using floor plate marker, CORIN. We scalable culture conditions on laminin fragment, and the sorted CORIN(+) expressed markers, FOXA2 LMX1A. When transplanted into...
High-performance poly-Si TFTs were fabricated by a low-temperature 600 degrees C process utilizing hard glass substrates. To achieve low threshold voltage (V/sub TH/) and high field-effect mobility ( mu /sub FE/), the conditions for low-pressure chemical vapor deposition of active layer optimized. Effective hydrogenation was studied using multigate (maximum ten divisions) thin-poly-Si-gate TFTs. The crystallinity after thermal annealing at depended strongly on temperature maximum 550-560 C....
Abstract Human induced pluripotent stem cells (iPSCs) can provide a promising source of midbrain dopaminergic (mDA) neurons for cell replacement therapy Parkinson’s disease (PD). However, iPSC-derived donor inevitably contain tumorigenic or inappropriate cells. To eliminate these unwanted cells, sorting using antibodies specific markers such as CORIN ALCAM has been developed, but neither marker is ventral midbrain. Here we employ double selection strategy expressing both and LMX1A::GFP,...
Previously, we have shown that TAL1 and the LIM-only protein gene (LMO) are regularly coactivated in T-cell acute lymphoblastic leukemia (T-ALL). This observation is likely to relate findings LMO highly synergistic tumorigenesis double-transgenic mice. To understand molecular mechanisms of functional synergy between transcriptional regulation, tried identify downstream target genes regulated by a subtractive PCR method. One isolated genes, for retinaldehyde dehydrogenase 2 (RALDH2), was...
The mechanism underlying the determination of neurotransmitter phenotype in developing mesencephalon, particularly GABAergic versus glutamatergic fate, remains largely unknown. Here, we show mice that basic helix-loop-helix transcriptional repressor gene Helt (also known as Megane and Heslike) functions a selector determines over fate mesencephalon. was coincidently expressed all progenitor domains for mesencephalic neurons. In mesencephalon Helt-deficient embryos, neurons were mostly absent...
Cerebellar corticogenesis begins with the assembly of Purkinje cells into plate (PP) by embryonic day 14.5 (E14.5) in mice. Although dependence PP formation on secreted protein Reelin is well known and a prevailing model suggests that migrate along 'radial glial' fibers connecting ventricular pial surfaces, it not clear how behave response to initiate PP. Furthermore, what nascent look like vivo. When start axonogenesis must also be elucidated. We show generated E10.5 posterior...
Abstract —Cardiomyocytes are terminally differentiated cells characterized as withdrawal cell-cycle machinery, but nonetheless they known to express regulators. Because many proteins related the cell cycle induce apoptosis in proliferating cells, we examined involvement of these pathway cardiomyocytes. Primary rat cardiomyocytes were exposed a severe hypoxic condition apoptosis. The rate increased ≈40% under 24 hours hypoxia evaluated by TUNEL method. cyclin A protein level assessed...
Drosophila melanogaster somatic sexual differentiation is accomplished by serial function of the products sex-determination genes. Sex-lethal (Sxl), one such gene. It functionally expressed only in female flies. The sex-specific expression this gene regulated alternative mRNA splicing which results either inclusion or exclusion translation stop codon containing third exon. Although previous genetic and molecular analyses suggest that functional Sxl maintained a positive feedback loop, where...
Background Oligodendrocyte precursor cells ( OPC s) regulate neuronal, glial, and vascular systems in diverse ways display phenotypic heterogeneity beyond their established role as a reservoir for mature oligodendrocytes. However, the detailed changes of s after cerebral ischemia remain largely unknown. Here, we aimed to investigate roles reactive ischemic brain. Methods Results The behavior was evaluated mouse model stroke produced by transient middle artery occlusion vivo. For vitro...
The susceptibility to neurological and psychiatric disorders reveals sexual dimorphism in the structure function of human brains. Recent evidence has also demonstrated sex-related differences cellular components brain, including neurons, microglia, astrocytes, endothelial cells. Oligodendrocyte precursor cells (OPCs) regulate neuronal system various ways play crucial roles brain homeostasis beyond their well-known role as a reservoir for mature oligodendrocytes. Although recent studies have...
We investigate metal-insulator transitions in the half-filled Holstein-Hubbard model as a function of on-site electron-electron interaction U and electron-phonon coupling g. use several different numerical methods to calculate phase diagram, results which are excellent agreement. When is dominant, transition Mott insulator; when dominates, localized bipolaronic state. In former case, always found be second order. This contrast state, clearly first order for larger values U. also present...
The number of rRNA genes in Mycobacterium bovis BCG was examined by Southern hybridization end-labeled 5S, 16S, and 23S rRNAs with BamHI, PstI, SalI digests M. DNA. Each RNA probe gave only one radioactive band three kinds DNA digest. These results suggest that chromosomes may carry a minimum set genes. Hybridization randomly labeled SalI, BglII, PvuII from the same organism supported these conclusions. 6.4-kilobase-pair fragment containing entire structural for both 16S cloned into pBR322....
The complete nucleotide sequence of the 16S rRNA gene Mycobacterium bovis BCG was determined. Its coding region estimated to be 1,536 base pairs long. in M. has homologies 75 and 89% with those Escherichia coli Streptomyces lividans, respectively.