Katsumasa Kobayashi
A5013809362- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Diverticular Disease and Complications
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Intraperitoneal and Appendiceal Malignancies
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Tumor Research and Treatment
- Thyroid Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Abdominal vascular conditions and treatments
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Platelet Disorders and Treatments
- Cancer Treatment and Pharmacology
- Asthma and respiratory diseases
- Occupational and environmental lung diseases
- Hospital Admissions and Outcomes
- Abdominal Trauma and Injuries
- Xenotransplantation and immune response
- Vascular Anomalies and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Pancreatitis Pathology and Treatment
- Antimicrobial Peptides and Activities
Tokyo Metropolitan Bokutoh Hospital
2015-2024
Tokyo Medical University
2023
Kagoshima University
2023
Akita University
2023
Kitasato University
2023
American Society for Gastrointestinal Endoscopy
2022
University of Tsukuba Hospital
2013
Nagoya City University
2013
National Hospital Organization Mito Medical Center
2009
Kunitachi Sakura Hospital
1998-2000
Abstract In a previous study we showed that recombinant human tumor necrosis factor‐α (rTNF‐α) has no cytolytic effect on Meth A fibrosarcoma cells in vitro but it strong anti‐tumor activity vivo. the present work, define vivo mode of action rTNF‐α solid‐form implanted intradermally (i.d.) mice. exhibited when given intravenously (i.v.) 7 or 10 days after implantation, not 3 implantation. Light and electron microscopy impaired microcirculation by producing fibrin‐like substances newly formed...
INTRODUCTION: The bleeding source of hematochezia is unknown without performing colonoscopy. We sought to identify whether colonoscopy a risk-stratifying tool etiology and predict outcomes presenting symptoms can differentiate the etiologies in patients with hematochezia. METHODS: This multicenter retrospective cohort study conducted at 49 hospitals across Japan analyzed 10,342 admitted for outpatient-onset acute RESULTS: Patients were mostly elderly population, 29.5% had hemodynamic...
Abstract Background Direct and indirect clipping treatments are used worldwide to treat colonic diverticular bleeding (CDB), but their effectiveness has not been examined in multicenter studies with more than 100 cases. Objective We sought determine the short‐ long‐term of direct versus for CDB a nationwide cohort. Methods studied 1041 patients who underwent ( n = 360) or 681) at 49 hospitals across Japan (CODE BLUE‐J Study). Results Multivariate analysis adjusted age, sex, important...
Background The rebleeding risks and outcomes of endoscopic treatment for acute lower gastrointestinal bleeding (ALGIB) may differ depending on the location, type, etiology stigmata recent hemorrhage (SRH) but have yet to be fully investigated. We aimed identify high risk SRH propose an optimal strategy. Methods retrospectively analyzed 2699 ALGIB patients with at 49 hospitals (CODE BLUE-J Study), whom 88.6 % received treatment. Results 30-day rates untreated significantly differed among...
Currently, large, nationwide, long-term follow-up data on acute lower gastrointestinal bleeding (ALGIB) are scarce. We investigated risks of recurrence after hospital discharge for ALGIB using a large multicenter dataset.
Portal vein thrombosis (PVT) is one of the common complications liver cirrhosis. Although anticoagulation contributes to thrombus resolution and considered first-choice treatment, its impact on patients' prognosis still controversial. This study aimed clarify benefit mortality, function, incidence cirrhosis-related in cirrhotic PVT patients.We conducted a multicenter retrospective review which we included 78 eligible patients with out 439. After propensity score matching, 21 were each...
The study aimed to identify prognostic factors for patients with acute lower gastrointestinal bleeding and develop a high-accuracy prediction tool. analysis included 8254 cases of hematochezia who were admitted urgently based on the judgment emergency physicians or gastroenterology consultants (from CODE BLUE J-study). Patients randomly assigned derivation cohort validation in 2:1 ratio using random number table. Assuming that present at time admission are involved mortality within 30 days...
Background and AimsWe aimed to determine the optimal timing of colonoscopy factors that benefit patients who undergo early for acute lower GI bleeding.MethodsWe identified 10,342 with hematochezia (CODE BLUE-J study) admitted 49 hospitals in Japan. Of these, 6270 underwent a within 120 hours were included this study. The inverse probability treatment weighting method was used adjust baseline characteristics among (≤24 hours, n = 4133), elective (24-48 1137), late (48-120 1000) colonoscopy....
Background/Aims: Recently, endoscopic detachable snare ligation (EDSL) has become increasingly common as treatment for colonic diverticular hemorrhage. This study aimed to evaluate the efficacy and safety of EDSL in comparison with clipping (EC) Methods: From April 2013 September 2017, 131 patients were treated or EC at Tokyo Metropolitan Bokutoh Hospital. We retrospectively evaluated patient characteristics clinical outcomes, including early rebleeding rates (rebleeding within 30 days after...
Abstract Background and Aim The 10‐mm self‐expandable metal stent (SEMS) is the standard for endoscopic transpapillary biliary drainage before pancreatic cancer surgery. However, efficacy of stents thinner than 10 mm has not been adequately validated. Therefore, we aimed to evaluate safety a 6‐mm fully covered SEMS (FCSEMS) distal malignant obstruction (DMBO) during preoperative chemotherapy cancer. Methods This was single‐arm, multicenter, prospective phase II study initial DMBO primary...
Ligation therapy, including endoscopic detachable snare ligation (EDSL) and band (EBL), has emerged as an treatment for colonic diverticular bleeding (CDB); its comparative effectiveness risk of recurrent remain unclear, however. Our goal was to compare the outcomes EDSL EBL in treating CDB identify factors after therapy.We reviewed data 518 patients with who underwent (n = 77) or 441) a multicenter cohort study named Colonic Diverticular Bleeding Leaders Update Evidence From Multicenter...
Abstract Background The value of endoscopy for acute lower GI bleeding (ALGIB) remains unclear, given few large cohort studies. We aim to provide detailed clinical data ALGIB management and identify patients at risk adverse outcomes based on endoscopic diagnosis. Methods conducted a multicenter, retrospective study, named CODE BLUE J-Study, in 49 hospitals throughout Japan studied 10,342 cases admitted outpatient-onset hematochezia. Results Cases were mostly elderly, with 29.5% hemodynamic...
Abstract Background and Aim While short long attachment caps are available for colonoscopy, it is unclear which type more appropriate stigmata of recent hemorrhage (SRH) identification in acute hematochezia. This study aimed to compare the performance versus hematochezia diagnoses outcomes. Methods We selected 6460 patients who underwent colonoscopy with from 10 342 cases CODE BLUE‐J study. performed propensity score matching (PSM) balance baseline characteristics between cap users. Then,...
The hemostatic mechanism of endoscopic detachable snare ligation (EDSL) for colonic diverticular hemorrhage (CDH) is similar to that band ligation, which effective and safe. However, because reports on EDSL are scarce, we conducted a two-center cohort study evaluate its effectiveness.
Stigmata of recent hemorrhage (SRH) directly indicate a need for endoscopic therapy in acute lower gastrointestinal bleeding (LGIB). Colonoscopy would be prioritized patients with highly suspected SRH, but the predictors colonic SRH remain unclear. We aimed to construct predictive model efficient detection using nationwide cohort.We retrospectively analyzed 8360 admitted through hospital emergency departments LGIB CODE BLUE-J Study (49 hospitals throughout Japan). All underwent inpatient...
Anti-tumor activities of lemnalol (I), a new ylangene-type sesquiterpenoid isolated from the Japanese soft coral Lemnalia tenuis VERSEVELDT, its stereoisomer (II) and ketone derivative, lemnalone (III), were studied. Lemnalol (I) renders murine peritoneal exudate cells (PEC) cytotoxic, though it has no direct cytotoxicity itself, to syngeneic tumor in vitro, while also inhibits growth vivo. The does not show PEC-mediated or cytotoxicity, (III) exhibits strong vitro. It is suggested that...
The effects of a new antiallergic drug, quinotolast [sodium 5-(4-oxo-1-phenoxy-4H-quinolizine-3-carboxamido)tetrazolate monohydrate], were studied and compared with those tranilast, amlexanox, pemirolast, repirinast disodium cromoglycate (DSCG) in experimental allergic models. Quinotolast potently inhibited such type I reactions as passive cutaneous anaphylaxis (PCA) anaphylactic bronchoconstriction rats by both intravenous oral dosing. All these stronger than the reference drugs tested....