A5089312377- Inflammatory Bowel Disease
- Microscopic Colitis
- Diagnosis and treatment of tuberculosis
- Antimicrobial Peptides and Activities
- Gastric Cancer Management and Outcomes
- Autoimmune and Inflammatory Disorders
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Probiotics and Fermented Foods
- Trace Elements in Health
- Genetic factors in colorectal cancer
- Pediatric health and respiratory diseases
- Colorectal and Anal Carcinomas
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Esophageal Cancer Research and Treatment
- Anorectal Disease Treatments and Outcomes
- Celiac Disease Research and Management
- Neuropeptides and Animal Physiology
Sapporo Higashi Tokushukai Hospital
2015-2025
Toho University Medical Center Sakura Hospital
2022-2023
Toho University
2022-2023
Goethe University Frankfurt
2023
Tokushima Hospital
2023
Agaplesion Markus Hospital
2023
Asahikawa Medical University
2010-2013
Asahikawa Medical College Hospital
2000-2008
University of California, Irvine
2008
Asahikawa City Hospital
2005
The alpha-defensin antimicrobial peptide family is defined by a unique tridisulfide array. To test whether this invariant structural feature determines bactericidal activity, mouse cryptdin-4 (Crp4) tertiary structure was disrupted pairs of site-directed Ala for Cys substitutions. In series Crp4 disulfide variants whose cysteine connectivities were confirmed using NMR spectroscopy and mass spectrometry, mutagenesis did not induce loss function. the contrary, in vitro activities several...
Perianal lesion is a refractory phenotype of Crohn's disease [CD] with significantly diminished quality life. We evaluated the clinical characteristics perianal lesions in newly diagnosed CD patients and impact on life Japanese CD.
The objectives of this real-world study were to determine 1-year persistence with vedolizumab in patients ulcerative colitis and evaluate factors contributing loss response. In multicenter, retrospective, observational chart review, moderately severely active who received ≥ 1 dose clinical practice at 16 tertiary hospitals Japan (from December 2018 through February 2020) enrolled. Persistence was 64.5% (n = 370); the median follow-up time 53.2 weeks. Discontinuation due response among...
Abstract Background Even after resolving pandemic, the verification of COVID-19 vaccination is important to optimise against next crisis.1,2 Methods Data at 39 institutes were prospectively acquired eight predetermined timepoints before and three manufacturers’ recommended vaccine doses including 3rd booster in a multicentre observational controlled study (UMIN000043545).3 Blood sample collections measure anti-SARS-CoV-2 spike IgG antibody titers planned prior each vaccination, 4 weeks, 3...
Using a large health insurance database in Japan, we examined the real-world usage of budesonide enteric-coated capsules (BUD) treating Crohn's disease. We analyzed data from Japan Medical Data Center claims for disease patients prescribed BUD April 2016 to March 2021, focusing on prescription status, adverse events (AEs), monitoring tests, and concomitant medications over 2 years following initiation. Patients were categorized into two groups based duration: ≤1 year >1 year. Of 7364...
Hedgehog signaling is important in the pathogenesis of pancreatic cancer. Several recent observations suggest involvement sonic hedgehog (SHH) postnatal neovascularization. We identified a novel role for SHH tumor‐associated angiogenesis Immunohistochemical analysis revealed that patched homolog 1 (PTCH1), both receptor and transcriptional target signaling, was expressed small fraction endothelial cells within cancer, but not normal tissue. When progenitor (EPC) isolated from human...
Abstract Background Given the increasing health concerns for patients with inflammatory bowel disease (IBD), amidst COVID-19 pandemic, we investigated impact of pandemic on anxiety and behavioral changes in Japanese IBD. Methods We analyzed 3032 questionnaires from IBD, aged 16 years or older visiting 30 hospitals 1 clinic between March 2020 June 2021. The primary outcome was score experienced by IBD during pandemic. Results Participants reported a median age 44 years; 43.3% were women....
To clarify field cancerization in the stomach by genetic alterations, we studied 83 cases of intestinal-type gastric cancer (GC) and paired intestinal metaplasia (IM) distant from GC 39 chronic gastritis with IM (CG-IM) for instability (GIN). Microsatellite (MSI) loss heterozygosity (LOH) were evaluated at 5 microsatellite loci. The incidence GIN was 21% (8/39) CG-IM, 48% (40/83) GC-IM, 65% (54/83) showed a significant difference among these 3 categories. By tumor location, MSI highest GC-IM...
Abstract Background Real-world data regarding ustekinumab (UST) for ulcerative colitis (UC) particularly in biologics-naïve patients is currently limited. This study aimed to elucidate the real-world effectiveness and safety of UST UC. Methods Overall, 150 with UC treated from March 2020 January 2023 were enrolled across 7 referral hospitals. To assess clinical efficacy persistence UST, retrospective analyses conducted weeks 8 56. Predictive factors concerning response examined through...
Human defensin-5 (HD-5) is one of the major antimicrobial peptides secreted by Paneth cells in human small intestine. HD-5 produced and stored as a propeptide cell granules, response to stimulation cholinergic reagents or bacterial antigens. The activation process trypsin occurs intestinal lumen produce mature HD-5. This study evaluated difference between proHD-5 bactericidal activity induction chemokine secretion vitro. Mature showed activities against all strains. Though, without enzymatic...
INTRODUCTION: The aim of this study was to evaluate the effect biologics on risk advanced-stage inflammatory bowel disease (IBD)-associated intestinal cancer from a nationwide multicenter data set. METHODS: medical records patients with Crohn's (CD) and ulcerative colitis (UC) diagnosed IBD-associated neoplasia (dysplasia or cancer) 1983 2020 were included in study. Therapeutic agents classified into 3 types: biologics, 5-aminosalicylic acid, immunomodulators. pathological stage compared...
Endoscopy is important to determine the effectiveness of treatment for Crohn's disease (CD), but searching entire small intestine difficult. Thus, we investigated usefulness leucine-rich alpha-2 glycoprotein (LRG), a new biomarker predicting mucosal activity, in evaluating activity CD intestinal lesions. This will further whether results bowel capsule endoscopy (SBCE) affect prognosis patients with CD.A total 114 who underwent SBCE were included. We analyzed correlation between LRG and...
There have been limited reports on the clinical efficacy of golimumab (GLM) in Japanese patients with ulcerative colitis (UC) real practice. This study aimed to explore real-life effectiveness and factors associated response GLM UC.This observational, retrospective, multicenter was conducted hospitals expertise inflammatory bowel disease treatment. Sixty-three treated active UC were included analysis. Clinical remission (CR) (partial Mayo (pMayo) score ≤2) induction maintenance phases after...
See Editorial "Subcutaneous integrin inhibitors may provide more treatment options for patients with moderate-to-severe ulcerative colitis" in Volume 17 on page 283.
Abstract Background The spread of coronavirus disease 2019 (COVID-19) had a major impact on the health people worldwide. clinical background and course inflammatory bowel (IBD) among Japanese patients with COVID-19 remains unclear. Methods This study is an observational cohort IBD diagnosed COVID-19. Data age, sex, (classification, treatment, activity), symptoms severity, treatment were analyzed. Results From 72 participating facilities in Japan, 187 registered from June 2020 to October...