A5037263900- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Liver Disease and Transplantation
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Neuroendocrine Tumor Research Advances
- Biliary and Gastrointestinal Fistulas
- Genetic and Kidney Cyst Diseases
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
Nippon Medical School
2013-2022
Hiroshima University
2020
Nippon Medical School Hospital
2008-2017
The University of Tokyo
1998-2011
Kitamurayama Hospital
2008
Tokyo University of Agriculture and Technology
2005
Ministry of Finance
1998
National Cancer Center
1994-1997
Kyoto City Hospital
1993-1994
Kyoto University
1990-1992
Patients with long-standing ulcerative colitis (UC) are known to have an increased risk for the development of colorectal cancer (CRC). The aim this study was clarify cumulative dysplasia or invasive and effectiveness surveillance colonoscopy in Japanese population. A total 217 patients received a 1027 colonoscopies between January 1979 December 2001 at University Tokyo hospital. found group were compared those referred our hospital from other hospitals without colonoscopy. Surveillance...
Objective. Cytomegalovirus (CMV) infection has been reported as an exacerbating factor in inflammatory bowel disease but the relationship between CMV and ulcerative colitis (UC) remains unclear. There no detailed research to elucidate clinicopathologic features of UC using surgical specimens. The aim this study was investigate patients who had undergone colectomy.Material methods. Surgical specimens taken from were examined for infection. divided into three groups: severe, refractory,...
Ulcerative colitis (UC) is associated with a high risk of colorectal cancer. To identify genes that could predict the development cancer in UC, we conducted DNA microarray analysis using nonneoplastic rectal mucosa UC patients.Gene expression 53 patients were examined. Gene profiles examined human Genome U133 Plus 2.0 gene chip array (Affymetrix). Among patients, 10 had UC-associated (UC-Ca group) whereas 43 did not (UC-NonCa group).By comparing mucosae between UC-Ca and UC-NonCa groups, 40...
contributed to improvements in patients' quality of life. 1 Many clinical observations have confirmed that anti-TNF-α mAbs are efficacious for the treatment CD.Unfortunately, however, we faced with a new complication: loss response (LOR).In Japan at time this study, an infliximab (IFX) dose escalation regimen 10 mg/kg was only allowed patients who developed LOR during scheduled maintenance therapy IFX (5 every 8 weeks) according results preapproval trial.However, often encounter cannot gain...
The noninferiority of pH-dependent release mesalamine (Asacol) once daily (QD) to 3 times (TID) administration was investigated.This a phase 3, multicenter, randomized, double-blind, parallel-group, active-control study, with dynamic and stochastic allocation using central registration. Patients ulcerative colitis in remission (a bloody stool score 0, an disease activity index ≤2), received the study drug (Asacol 2.4 g/d) for 48 weeks. primary efficacy endpoint nonrecurrence rate assessed on...
This study was undertaken to investigate factors that influenced differential diagnosis of dysplasia-associated lesion or mass and coincidental adenoma in patients with ulcerative colitis.Among 346 colitis who underwent colonoscopy between 1979 1995, 27 had macroscopic neoplastic lesions were divided into two groups: those (16 patients) (11 patients), each being categorized by the presence absence dysplasia flat mucosa adjacent elevated lesions, respectively.Thirteen detected colonoscopic...
Although ãlpha-chemokines, such as interleukin (IL)-8 and epithelial neutrophil-activating peptide 78, are implicated in the pathogenesis of inflammatory bowel disease (IBD), little information is currently available on expression cellular source growth-related gene product-alpha (GROalpha) its functional relationship to other ãlpha-chemokines intestinal mucosa patients with IBD.The contents IL-8 GROalpha organ cultures, mRNA, modulatory effects mediators GROalpha-producing cells were...
<b><i>Background:</i></b> US and European guidelines recommend budesonide for the treatment of mild-to-moderate active ileocolic Crohn's disease (CD). However, has not been approved, mesalazine is widely used as first-line in Japan. The objective this study was to evaluate efficacy safety patients with CD <b><i>Methods:</i></b> In phase 3 noninferiority (NCT01514240), 112 a baseline Disease Activity Index (CDAI) score 180-400 were randomized or...
The influence of combined replenishment L-3,5,3′-triiodothyronine (T3) and vasopressin (antidiuretic hormone [ADH]) on both hepatic metabolism systemic hemodynamics was assessed in brain-dead dogs. Arterial ketone body ratio (AKBR) measured as a parameter metabolism, which reflects the redox state (free nicotinamide adenine dinucleotide/reduced dinucleotide) liver mitochondria. Mean arterial blood pressure (MAP) significantly decreased from 110.4±3.8 to 44.4±1.7 mmHg, at 1 hr after...
Mesalazine preparations are widely used to treat mild moderately severe ulcerative colitis (UC). We compared once-daily administration of oral mesalazine in patients with quiescent UC the established 3-times-daily prescription, assessing efficacy and safety each method maintaining remission for 52 weeks.This was a double-blind, double-dummy, randomized, multicenter noninferiority study which 301 were randomly assigned treatment groups administered prolonged-release at doses 1.5 2.25 g/d once...
Adjuvant Chemotherapy Trial of TS-1 for Colon Cancer (ACTS-CC), a randomised phase III trial, demonstrated that adjuvant therapy with S-1 stage colon cancer was non-inferior in 3-year disease-free survival (DFS) to tegafur-uracil plus leucovorin (UFT/LV). We updated DFS and overall (OS) performed T x N subset analysis.A total 1518 patients curatively resected were randomly assigned receive (80-120 mg/day on days 1-28 every 42 days, four courses) or UFT/LV (UFT: 300-600 LV: 75 35 five...
Background/Aims: A subgroup analysis was conducted in Japanese patients with moderate to severe ulcerative colitis (UC) enrolled the phase 3 VISIBLE 1 study, which evaluated safety and efficacy of a new vedolizumab subcutaneous (SC) formulation.Methods: Eligible received open-label infusions 300 mg intravenous (IV) at weeks 0 2 induction phase. Patients clinical response by complete Mayo score week 6 entered double-blind maintenance were randomized 108 SC every weeks, placebo, or IV 8 weeks....
We describe a patient with symptomatic giant hepatic hemangioma treated hepatectomy. A 53-year-old woman presented upper abdominal distension and appetite loss. The medical history included multiple hemangiomas that had been detected 2 years earlier but were left untreated. Initial laboratory tests revealed pancytopenia mild coagulopathy. Computed tomography magnetic resonance imaging demonstrated hemangioma, 27 cm in diameter, the enlarged right lobe of liver. inferior vena cava was...
We present a rare case of hepatocellular carcinoma (HCC) in which spontaneous complete necrosis was confirmed with surgical resection. An 80-year-old man HCC referred to Nippon Medical School Tama Nagayama Hospital. The medical history included hypertension, managed medication, and partial lobectomy the lung owing schwannoma. A previously untreated abdominal aortic aneurysm, 51 mm maximum diameter, detected. serum concentration proteins induced by vitamin k antagonism or absence (PIVKA-2)...
MANAKA, DAI; OKAMOTO, RYOJI; YOKOYAMA, TADASHI; YAMAMOTO, YUZO; WASHIDA, MASANOBU; INO, KEHCHIRO; YAMAOKA, YOSHIO; KUMADA, KAORU; OZAWA, KAZUE Author Information
An 81-year-old woman, who had undergone left radical nephrectomy for renal cell carcinoma 17 years previously, was found to have a mass approximately 5cm in diameter the body of pancreas and an early gastric cancer. The patient suspected having pancreatic metastasis from cancer underwent distal pancreatectomy, splenectomy, gastrectomy. Histologic examination showed that tumor clear metastasized well-differentiated adenocarcinoma invaded mucosa. Twenty months after operation, well, without...
The uterus, ovary, and fallopian tube are rarely present in an inguinal hernia. We report on operation to treat just such a rare condition for right An 87-year-old Japanese woman was admitted with swelling the region purulent discharge from vagina. Vital signs were stable, but mobile mass irreducible. Computed tomography of abdomen indicated uterine tissue diagnosed hernia incarcerated uterus performed surgery that basis. incision approximately 6 cm long made skin above swollen area open...