A5069005175- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Mycorrhizal Fungi and Plant Interactions
- Fungal Biology and Applications
- Synthesis and Properties of Aromatic Compounds
- Plant Pathogens and Fungal Diseases
- Advanced Power Amplifier Design
- Radio Frequency Integrated Circuit Design
- Organic and Molecular Conductors Research
- Photochromic and Fluorescence Chemistry
- Organic Chemistry Cycloaddition Reactions
- Porphyrin and Phthalocyanine Chemistry
- Crystallography and molecular interactions
- Forest Ecology and Biodiversity Studies
- Concrete and Cement Materials Research
- Neuroscience and Neuropharmacology Research
- Semiconductor Lasers and Optical Devices
- GaN-based semiconductor devices and materials
- Pluripotent Stem Cells Research
- Innovative concrete reinforcement materials
- Oxidative Organic Chemistry Reactions
- Advancements in Battery Materials
- Wireless Power Transfer Systems
- Luminescence and Fluorescent Materials
- Semiconductor materials and devices
Osaka University
1982-2024
Kyoto University
2001-2023
KRI
2023
EA Pharma (Japan)
2018-2022
Kumamoto University
2022
Tosei General Hospital
2022
Shinshu University
2008-2020
Ōtani University
2006-2020
Shiga Medical Center
1989-2019
Lake Biwa Museum
2019
Effects of a perfluorosulfonate ionomer (PFSI) and polytetrafluoroethylene (PTFE) loaded carbon (PTFE‐C) on the catalyst layer in electrode polymer electrolyte fuel cell (PEFC) prepared by new method based process PFSI‐colloid formation were investigated electrochemical techniques mercury pore sizer. The microstructure its effect PEFC performance affected contents both PFSI PTFE‐C. has two distinctive distributions with boundary ca. 0.04 μm. volume larger (secondary pore) deceased an...
Analysis of ALS patient iPSC-derived motor neurons indicates that Src/c-Abl inhibitors may have potential for treating ALS.
Highlights•Rapid, robust neuronal induction from human iPSCs to model AD drug responsiveness•iPSC-based screening of pharmaceutical compounds for Aβ phenotypes•A combination existing drugs synergistically improve phenotypes AD•Anti-Aβ cocktail decreases toxic levels in neurons derived patients' cellsSummaryIn the process development, vitro studies do not always adequately predict human-specific responsiveness clinical trials. Here, we applied advantage iPSC-derived neurons, which offer...
Effects of microstructure carbon supports for platinum catalyst and perfluorosulfonate‐ionomer (PFSI) distribution in the layer on consequent performance polymer‐electrolyte fuel cells, prepared by a new method based process PFSI colloid formation, were investigated electrochemical techniques, mercury pore sizer, adsorption [Brunauer‐Emmett‐Teller Barrett‐Joyner‐Halenda] methods, CO adsorption. The its effect cell affected contents supports. distributed distinctive pores 0.04 to 1.00 μm....
A new preparation method for the catalyst layer in electrodes of a polymer electrolyte fuel cell, based on process preparing perfluorosulfonate‐ionomer (PFSI) colloid, was developed. In this method, both good network PFSI and uniformity PFSIs Pt particles were achieved with colloid formation chains specific organic solvents. The applicable solvents had dielectric constants ranging from 3 to 10. colloids selectively adsorbed onto carbon agglomerates highly dispersed surface, paste‐formation...
We have previously reported a preparation process for the catalyst layer of polymer electrolyte fuel cells (PEFCs) using perfluorosulfonate ionomer (PFSI) colloid. In this paper we report recent improvements in method preparation. present method, carbon‐supported platinum (Pt‐C) was mixed with poor solvent PFSI and solution added to mixture. The colloidal formed immediately adsorbed on Pt‐C without coagulation. As result, reaction area increased, internal resistance decreased, gaseous...
Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized by extraskeletal bone formation through endochondral ossification. Patients with FOP harbor point mutations in ACVR1, type I receptor for BMPs. Although mutated ACVR1 (FOP-ACVR1) has been shown to render hyperactivity BMP signaling, we others have uncovered mechanism which FOP-ACVR1 mistransduces signaling response Activin-A, molecule that normally transduces TGF-β signaling. Activin-A evokes enhanced...
The first step in developing regenerative medicine approaches to treat renal diseases using pluripotent stem cells must be the generation of intermediate mesoderm (IM), an embryonic germ layer that gives rise kidneys. In order achieve this goal, establishing efficient, stable and low-cost method for differentiating IM small molecules is required. study, we identified two retinoids, AM580 TTNPB, as potent inducers by high-throughput chemical screening, established rapid (five days) efficient...
This paper summarizes the relation between molecular structure and dispersion-adsorption mechanisms of 3 types comb-type superplasticizers used in Japan. The action compatibility cements are influenced by polymers such as copolymer components grafted chain length poly (ethylene-oxide) (PEO). Many reports regarding concrete research have investigated influence on fluidity production selfcompacting concrete. However, many not considered effect structures superplasticizers. should be useful for...
The effects of carbon supports for platinum‐ruthenium (Pt‐Ru) catalysts on anode performance direct methanol fuel cells (DMFC) were investigated. Good polarization characteristics the electrode obtained a Pt‐Ru catalyst supported an acetylene black with high specific surface area and pore size distribution in range 3 to 8 nm. increased increase volume Analyses various blacks carried out several techniques: adsorption (Brunauer‐Emmett‐Teller (BET) Barrett‐Joyner‐Halenda (BJH) methods),...
The properties of Ta2N and TaN compound films as a diffusion barrier between Cu Si have been investigated by examining compositional depth profiles obtained Auger electron spectroscopy. use is effective for improving the thermal stability contact system raising silicide formation temperature compared with Ta barrier. Cu/TaN/Si fairly stable due to annealing 1 h even at 750 °C. This interpreted compound, which chemically inert well this temperature. Eliminating grain growth also suppressing...
Abstract A rapid and convenient procedure for the quantitative determination of fatty acid composition plasma lipids is described. Human was applied directly to preadsorbent zones thin‐layer silica gel plates with added antioxidant, internal standards carriers. The chromatography (TLC) were partially developed methanol followed by chloroform/methanol (1∶1, v/v), then they fully in hexane/diethyl ether/acetic (80∶20∶1, v/v/v) separate major classes lipids. Silica from regions containing...
We developed a novel inbred strain of mouse with age-related brain atrophy and it was named "Senescence Accelerated Mouse (SAM)-P/10." Macroscopic morphometry indicated that the brains SAM-P/10 showed age-dependent involutional changes mainly in frontal portion cerebrum. The weight decreased by 8.6% throughout lifespan. There were no obvious defects postnatal development. Semi-macroscopic revealed prominent neocortex, olfactory cortex amygdala. Microscopic neocortical neurons lost aging,...
This paper describes the history and new trends in development of chemical admixtures Japan. PC (polycarboxylic acid)-based agents are main products superplasticizer market. A low-stickiness type PC-based has been developed based on conventional superplasticizer. The flowing speed concrete with low stickiness is faster than that By addition a viscosity agent consisting mix anionic cationic surface active agents, three dimensional reticulation structures formed fresh cement paste can be...
The relationship between adenylate cyclase activity in the synaptic membrane fraction (M1) of rat brain and lipid peroxidation these membranes was examined. In presence 5 mM dithiothreitol (DTT), 1 to 10 microM Fe/+ activated 2- 4-fold. Of several metal ions, Fe2+ most effective. Other enzymes M1, such as Mg2+-ATPase, (Na+-K+)-ATPase, 5'-nucleotidase, acetylcholinesterase, phosphodiesterase, were not by plus DTT. Activation DTT accompanied production malondialdehyde, a product peroxidation....
Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disorder characterized by extraskeletal bone formation through endochondral ossification. FOP patients harbor gain-of-function mutations in ACVR1 (FOP-ACVR1), type I receptor for morphogenetic proteins. Despite numerous studies, no drugs have been approved FOP. Here, we developed high-throughput screening (HTS) system focused on the constitutive activation of FOP-ACVR1 utilizing chondrogenic ATDC5 cell line that stably...
To deal with the broad spectrum of coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that threaten human health, it is essential to not only drugs develop target viral proteins but also consider host proteins/cellular processes protect them from being hijacked for infection and replication. this end, has been reported autophagy deeply involved in infection. In study, we used airway organoids screen a chemical library autophagic modulators identify...
Mowat–Wilson syndrome (MWS) is a multiple congenital anomaly characterized by moderate or severe intellectual disability, characteristic facial appearance, microcephaly, epilepsy, agenesis hypoplasia of the corpus callosum, heart defects, Hirschsprung disease, and urogenital/renal anomalies. It caused de novo heterozygous loss function mutations including nonsense mutations, frameshift deletions in ZEB2 at 2q22. encodes zinc finger E‐box binding homeobox 2 protein consisting 1,214 amino...
The reaction of several azulenylalkynes having an aryl substituent with elemental sulfur afforded the corresponding azuleno[2,1-<italic>b</italic>]thiophenes in good yields.