A5035454390- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Inflammatory Bowel Disease
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Anorectal Disease Treatments and Outcomes
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Diverticular Disease and Complications
- Autoimmune and Inflammatory Disorders
- Colorectal Cancer Screening and Detection
- Intraperitoneal and Appendiceal Malignancies
- Hepatocellular Carcinoma Treatment and Prognosis
- Metastasis and carcinoma case studies
- Virus-based gene therapy research
- Abdominal vascular conditions and treatments
- Cancer Research and Treatments
- Diagnosis and treatment of tuberculosis
- Appendicitis Diagnosis and Management
- Multiple and Secondary Primary Cancers
- Stoma care and complications
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
Nara Medical University Hospital
2015-2025
Nara Medical University
2015-2025
The University of Tokyo
2007-2018
PROBLEM: Recurrent spontaneous abortion (RSA) is a common complication of pregnancy for which there no known cure. Therefore, effective treatment needed. Published results from controlled clinical trials allogeneic leukocyte immunization women suffering RSA have given conflicting results. To address this controversy, the international raw data all patients who had been entered into that included control group were collected and analyzed. The primary question to be answered was whether...
RECK, a membrane-anchored regulator of matrix metalloproteinases (MMPs), is widely expressed in healthy tissue, whereas it at lower levels many tumor-derived cell lines. Studies mice and cultured cells have shown that restoration RECK expression inhibits tumor invasion, metastasis, angiogenesis. However, the clinical relevance these findings remains to be fully documented. Here we examined one its targets, MMP-9, colorectal cancer tissue.The MMP-9 samples from 53 patients were determined by...
Colitis-associated intestinal cancer (CAC) can develop in patients with inflammatory bowel disease; however, the malignant grade of CAC may differ from that sporadic colorectal (CRC). Therefore, we compared histological findings distinct stage between and CRC to evaluate features CAC.
Abstract Background Chemotherapy is the typical choice for treating colorectal cancer with synchronous peritoneal metastases. Nonetheless, surgical resection may be chosen if metastases are resectable. Unfortunately, there no reliable preoperative or intraoperative prognostic indicator. This study aimed to determine significance of Glasgow score (GPS) in patients Methods We conducted a prospective on 143 and concurrent Our analysis included factors, such as GPS, using data from institutional...
To clarify the risk factors affecting prognosis after primary tumor resection (PTR) in patients with metastatic colorectal cancer synchronous peritoneal metastasis (mCRC-SPM). Patients were enrolled prospectively JSCCR project "Grading of Peritoneal Seeding Colorectal Cancer." Factors that may influence overall survival-age, sex, location tumor, lymph node metastasis, presence liver degree index (PCI), cure, and postoperative chemotherapy-in PTR group examined using multivariate analysis. Of...
Abstract Aim Ulcerative colitis (UC) is a known contributor to the development of colitis‐associated cancer (CAC), although exact mechanism remains be elucidated. CAC typically presents as flat type macroscopically and manifests histologically mucinous carcinoma signet ring cell carcinoma. While relationship between disease duration chronic inflammation has been studied, impact on outcomes yet thoroughly investigated. The aim this study examine effect UC clinicopathological features CAC....
Endoscopic phenotypes of pouchitis according to the Chicago Classification have been reported be associated with poor pouch outcomes in ulcerative colitis (UC). Here, we aimed assess prevalence endoscopic and their predictability for outcomes. This retrospective multicenter study included UC patients aged 18 years or older who underwent total colectomy between January 2000 March 2020. The primary endpoints were frequencies chronic failure. findings evaluated at initial pouchoscopy 3 10 after...
Primary tumor location of colon cancer has been reported to affect the prognosis after curative resection. However, some reports suggested impact was varied by stage. This study analyzed prognostic sidedness in stages II, III, and liver metastasis resection using propensity-matched analysis.Right-sided defined as a located from cecum splenic flexure, while any more distal left-sided cancer. Patients who underwent at Nara Medical University hospital between 2000 2016 were analyzed.There 110...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 593:127-139 (2018) - DOI: https://doi.org/10.3354/meps12514 Reconstruction of salinity history associated with movements mangrove fishes using otolith oxygen isotopic analysis Kotaro Shirai1,*, Futa Koyama2, Naoko Murakami-Sugihara1, Kusuto Nanjo3, Tomihiko Higuchi1, Hiroyoshi Kohno4, Yoshiro Watanabe1, Ken...
INTRODUCTION: Colorectal cancer (CRC) is one of the major life-threatening complications in patients with Crohn's disease (CD). Previous studies CD-associated CRC (CD-CRC) have involved only small numbers patients, and no large series been reported from Asia. The aim this study was to clarify prognosis clinicopathological features CD-CRC compared sporadic CRC. METHODS: A nationwide database used identify (n = 233) 129,783) over a 40-year period, 1980 2020. Five-year overall survival (OS),...
INTRODUCTION: The aim of this study was to evaluate the effect biologics on risk advanced-stage inflammatory bowel disease (IBD)-associated intestinal cancer from a nationwide multicenter data set. METHODS: medical records patients with Crohn's (CD) and ulcerative colitis (UC) diagnosed IBD-associated neoplasia (dysplasia or cancer) 1983 2020 were included in study. Therapeutic agents classified into 3 types: biologics, 5-aminosalicylic acid, immunomodulators. pathological stage compared...
Oxaliplatin-based chemotherapy is widely used to treat advanced colorectal cancer (CRC). Sinusoidal obstruction syndrome (SOS) due oxaliplatin a serious type of chemotherapy-associated liver injury (CALI) in CRC patients. SOS thought be caused by the sinusoidal endothelial cell damage, which results release unusually-large von Willebrand factor multimers (UL-VWFMs) from cells. To investigate pathophysiology CALI after oxaliplatin-based chemotherapy, we analyzed plasma concentration (VWF) and...
The novel 2019 coronavirus disease (COVID-19), which is caused by infection with the severe acute respiratory syndrome 2, has spread rapidly around world and many deaths. COVID-19 involves a systemic hypercoagulable state arterial/venous thrombosis induces unfavorable prognosis. Herein, we present first case in East Asia where an superior mesenteric artery (SMA) occlusion associated pneumonia was successfully treated surgical intervention.A 70-year-old man presented to his local physician...
Moderate rectal distension elicits recto-rectal reflex contractions and simultaneous recto-internal anal sphincter relaxations that together comprise the defecation reflex. Both reflexes are controlled by 1) pelvic nerves, 2) lumbar colonic 3) enteric nervous system. The aim of present study was to explore a novel approach repairing dysfunction using plasticity pathways. Experiments were performed in anesthetized guinea pigs with ethyl carbamate. rectum 30 mm oral from verge transected...
Coagulation factor IX (FIX) is synthesized by hepatocytes, and the lack of this protein causes hemophilia B. Liver nonparenchymal cells, including liver sinusoidal endothelial cells (LSECs) extrahepatic in body, are scarcely shown to have an ability synthesize secrete FIX. The present study investigated existence responsible for synthesizing FIX other than hepatocytes mice using gene expression analyses FIX-specific clotting assays. Among several organs investigated, liver, lung, spleen,...