A5033657263- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Hernia repair and management
- Inflammatory Biomarkers in Disease Prognosis
- Intestinal and Peritoneal Adhesions
- Genetic factors in colorectal cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Urological Disorders and Treatments
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Gastrointestinal disorders and treatments
- Anorectal Disease Treatments and Outcomes
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Sexual Differentiation and Disorders
- Testicular diseases and treatments
- MRI in cancer diagnosis
Tokai University
2014-2025
Tokai University Hospital
2016-2019
Shonan Oiso Hospital
2016-2017
Serum carcinoembryonic antigen (CEA) has been widely used for postoperative surveillance colorectal cancer. However, serum CEA a poor diagnostic accuracy detecting recurrence. We tested the hypothesis that determining cutoff values according to preoperative levels would enhance accuracy.Serum was measured before and 1-6 months after surgery in 783 patients with curatively resected colon cancer from 2005 through 2013. The during were determined separately levels.In negative CEA, recurrence...
Abstract Aim Ulcerative colitis (UC) is a known contributor to the development of colitis‐associated cancer (CAC), although exact mechanism remains be elucidated. CAC typically presents as flat type macroscopically and manifests histologically mucinous carcinoma signet ring cell carcinoma. While relationship between disease duration chronic inflammation has been studied, impact on outcomes yet thoroughly investigated. The aim this study examine effect UC clinicopathological features CAC....
Multidisciplinary treatments for advanced rectal cancer are diverse. Neoadjuvant chemoradiation therapy (nCRT) is a total neoadjuvant treatment option. Some studies have reported that tumor-infiltrating lymphocytes (TILs) and inflammatory blood factors [(neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), systemic immune index (SII)] predictors of nCRT efficacy. However, the relationship between changes in TILs during resulting tumor regression grade (TRG) remains unclear. In this...
Rectal cancer is associated with a higher rate of surgical complications. The ability to predict the risk complications before treatment would facilitate design personalized strategies optimally suited for each patient. We retrospectively studied 260 patients rectal who underwent radical surgery examine relations between and 5 types scores. Complications developed in 56 (21.5%). Nineteen had infectious complications, 16 intestinal obstruction, 12 other Twelve out 187 received low anterior...
Abstract Background Seprafilm did not decrease small bowel obstruction (SBO), but significantly decreased reoperation in patients with inflammatory disease. However, the preventive effect colon cancer remains unclear. Methods We conducted a randomized controlled trial cancer. The study group comprised 345 In seprafilm (n = 166), two sheets of were inserted under midline incision. Patients who admitted and required decompression considered to have SBO. Results median follow‐up was 61.9...
<b><i>Background:</i></b> To prevent surgical site infection (SSI) in colorectal surgery, the combination of mechanical bowel preparation (MBP), oral antibiotic (OABP), and intravenous antibiotics have been proposed as standard treatment. We conducted an RCT comparing incidence SSI between MBP + OABP alone after receiving a single dose antibiotics. <b><i>Methods:</i></b> The study group comprised 254 patients who underwent elective surgery for...
Although intracorporeal anastomosis (IA) for colon cancer requires longer operative time than extracorporeal (EA), its short-term postoperative results, such as early recovery of bowel movement, have been reported to be equal or better. As IA opening the intestinal tract in abdominal cavity under pneumoperitoneum, there are concerns about intraperitoneal bacterial infection and recurrence peritoneal dissemination due spread bacteria tumor cells. However, contamination medium-term oncological...
Mucinous rectal carcinoma has been reported to have a lower survival rate and poorer histologic response chemoradiotherapy(CRT). Magnetic resonance imaging (MRI) can accurately evaluate the amount of mucin pools (MP) in primary cancer tissue. We compared degree MP on MRI before after CRT with findings resected specimens investigate predictors CRT. The study group comprised 205 patients adenocarcinoma who received preoperative MPs were measured specimens. was classified into five classes...
Regorafenib and trifluridine/tipiracil (TAS-102) are novel antitumor agents for patients with refractory metastatic colorectal cancer. However, it is unclear which may derive a survival benefit from these drugs in real‑life clinical practice. We evaluated retrospectively the efficacy safety of regorafenib TAS‑102 at single institution between June 2013 November 2015. Cox regression analysis was carried out to obtain predictive scores (the nearest integers hazard ratio) benefit. Forty‑four...
The histologic response to neoadjuvant chemoradiotherapy (nCRT) has been intimately related outcomes in locally advanced rectal cancer. Serum carcinoembryonic antigen (CEA) levels change after nCRT and surgery as compared with before nCRT.The subjects were 149 patients cancer who received between 2005 2013. divided into 4 groups according the serum CEA levels: group 1, 55 negative nCRT; 2, 41 positive that became 3, 37 surgery; 4, 16 well surgery.Pathological complete response, T...
<b><i>Objective:</i></b> We previously reported that the largest diameter of retrieved lymph nodes (LNs) correlates with number LNs and is a prognostic factor in stage II colon cancer. examine whether T, B, natural killer (NK) cells are related to survival. <b><i>Methods:</i></b> The subjects comprised 320 patients An LN was selected each patient. positive area ratios stained for CD3 CD20, numbers CD56-positive were measured....
Abstract Aim Although the oncological impact of lateral lymph node dissection on enlarged nodes has been gradually accepted over last decade, that without swelling remains doubtful. This study aimed to develop a prediction model for future risk local recurrence and clarify value adding in locally advanced rectal cancer nodes. Methods retrospective, multi‐institutional recruited 812 patients with cStage II/III low <7 mm. Total was hypothetical when never performed. Results Overall, total...
<b><i>Background:</i></b> Colorectal neuroendocrine carcinoma (NEC) is a rare disease, and mixed cases with colorectal adenocarcinoma also exist. The histogenesis of this disease remains unclear. We studied the numbers marker-positive cells in tissue normal mucosal to investigate relation between NEC discuss NEC. <b><i>Methods:</i></b> total 354 curatively resected stage II or III colon cancer 36 rectal treated at Tokai University Hospital...
<b><i>Background:</i></b> Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains established. We previously that histological changes on biopsy specimens obtained 7 days after starting nCRT are strong predictors of response nCRT....
BackgroundIn rectal cancer who received chemoradiotherapy, the number of Lymph nodes (LNs) required remains unclear. We conducted a randomized controlled trial to determine whether preoperative tattooing increases LNs and enhances detection rate metastatic LNs.MethodsEighty patients with chemoradiotherapy were randomly assigned receive no (C group) or (T group).ResultsThe was significantly higher in T group (13.3 ± 7.4, mean SD) than C (8.8 5.9, p < 0.001), however, positive did not differ...
The National Comprehensive Cancer Network (NCCN) guidelines recommend local excision and observation as standard treatment for selected patients with clinical T1N0M0 rectal cancer. In pathological T1 (pT1) cancer who received excision, the recurrence rate is at least 10%. We studied oncological outcomes in pT1 chemoradiotherapy (CRT) after excision.Local was performed 65 (≤8 cm from anal verge, tumor size < 30 mm, well or moderately differentiated adenocarcinoma). CRT (40 45 Gy 1.8-2.0...
<b><i>Objective:</i></b> The histologic response to neoadjuvant chemoradiotherapy (CRT) has been intimately related outcomes in locally advanced rectal cancer. However, reliable prognostic factors have yet be established. <b><i>Subjects and Methods:</i></b> study group comprised 198 patients with cancer who received CRT. A modified classification based on the combination of ypStage tumor regression grade (TRG) was developed. II TRG 2 classified...
<b><i>Background:</i></b> FOLFIRI plus bevacizumab have been widely used as first-line treatment for metastatic colorectal cancer (mCRC). Pharmacokinetics and pharmacodynamics suggested a low dose of irinotecan given long-term infusion is expected to enhance antitumor activity. We conducted randomized phase II study compare oral S-1 with 24-h versus bevacizumab. <b><i>Methods:</i></b> The subjects comprised 120 chemotherapy-naïve patients mCRC....
In patients with colorectal cancer, the rate of recurrence increases as histologic stage progresses. However, prediction in individual is difficult. Many studies have reported on relation between outcomes and tissue-infiltrating lymphocytes (TILs). The aim our study was to clarify TILs oncologic colon cancer using propensity score matching analysis.The group comprised 513 who received curative resection. By for sex, age, tumor location, T stage, N type, adjuvant therapy conventional...
坐骨ヘルニアは,坐骨孔より脱出するヘルニアであり,閉鎖孔ヘルニアとともに骨盤底ヘルニアに分類されている.今回われわれは,閉鎖孔ヘルニアに併存していた坐骨ヘルニアの1例を経験した.症例は93歳,女性.右臀部から大腿背側にかけての疼痛,腹部膨満,嘔吐を主訴に受診した.腹部CT検査にて,右閉鎖孔ヘルニア嵌頓とそれに伴う小腸イレウス,右坐骨ヘルニアと診断し,手術を施行した.右閉鎖孔に小腸が嵌頓し壊死していたため,小腸部分切除術を施行した.右坐骨孔の小腸の嵌入は開腹時に自然整復されており,ヘルニア嚢の奥に傍卵巣嚢腫の嵌入を認め嚢腫切除術を施行した.右閉鎖孔・右坐骨孔は単純閉鎖した.閉鎖孔ヘルニアと坐骨ヘルニアは,骨盤底筋群の脆弱化という同様の機序がある.坐骨ヘルニアはすべてのヘルニアの中で最も稀と報告されているが,無症候性の場合もあり,両疾患の合併を念頭に置いた診断・治療が必要であると考えられた.
Preoperative chemoradiotherapy (CRT) using 5-fluorouracil (5-FU)-based chemotherapy is the standard of care for rectal cancer. The effect additional during period between completion radiotherapy and surgery remains unclear. Predictive factors CRT may differ combination with S-1 tegafur-uracil/leucovorin (UFT/LV).The subjects were 54 patients locally advanced cancer who received preoperative or UFT/LV. pathological tumor response was assessed according to regression grade (TRG). expression...