A5062791427- Electronic Packaging and Soldering Technologies
- 3D IC and TSV technologies
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Silicon Carbide Semiconductor Technologies
- Aluminum Alloys Composites Properties
- Liver physiology and pathology
- High voltage insulation and dielectric phenomena
- Copper Interconnects and Reliability
- Dielectric materials and actuators
- Influenza Virus Research Studies
- Advanced Welding Techniques Analysis
- Pancreatic function and diabetes
- Virus-based gene therapy research
- Semiconductor materials and interfaces
- RNA Interference and Gene Delivery
- Platelet Disorders and Treatments
- Semiconductor materials and devices
- Pluripotent Stem Cells Research
- Intermetallics and Advanced Alloy Properties
- Protease and Inhibitor Mechanisms
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Microstructure and mechanical properties
Waseda University
2014-2025
Nara Medical University
2011-2025
Nara Medical University Hospital
2024
University of North Carolina at Chapel Hill
2013-2021
Kindai University
2017-2021
University of North Carolina Health Care
2015-2020
Graduate School USA
1999-2020
IPS Research (United States)
2017-2019
Kansai University
2017-2018
Tokyo Women's Medical University
2009-2017
Patients with cancer have a higher risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), compared to the general population. Cancer-associated (CAT) is thrombotic event that occurs as complication or therapy. Major factors determining VTE in patients include not only treatment history patient characteristics, but also type site. Cancer types can be broadly divided into three groups based on risk: high (pancreatic, ovarian, brain, stomach,...
In tumors, extravascular fibrin forms provisional scaffolds for endothelial cell (EC) growth and motility during angiogenesis. We report that fibrin-mediated angiogenesis was inhibited tumor delayed following postnatal deletion of Tgfbr2 in the endothelium Cdh5-CreERT2 Tgfbr2fl/fl mice (Tgfbr2iECKO mice). ECs from Tgfbr2iECKO failed to upregulate fibrinolysis inhibitor plasminogen activator 1 (Serpine1, also known as PAI-1), due part uncoupled TGF-β-mediated suppression miR-30c. Bypassing...
The interface is critical for the design of polymer nanocomposites with desirable properties. effect behavior on properties low nanoparticle loading has been well documented. However, our understanding role in highly filled still limited because lack comprehensive research work. In this contribution, by using BaTiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> nanoparticles six kinds surface chemistry, we have prepared epoxy (50 vol%...
The knowledge of the structure-property relationship at nanoscale level is important to develop advanced dielectric polymer composites. Herein epoxy/polyhedral oligomeirc silsesquioxanes (POSS) composites with homogeneous nanostructure were prepared. Unlike conventional inorganic nanoparticles (e.g., silica) used for nanocomposite preparation, POSS molecules in this work have three advantages: a comparable size segments chains, being capable reacting base polymer, good solubility many...
To identify plasma biomarkers that can be early predictors of mortality in critically ill patients with primary influenza A/H1N1.A prospective, multicenter, case-cohort pilot study.Three academic ICUs.Fifteen A/H1N1 included seven survivors and eight nonsurvivors. For comparison, age- gender-matched healthy controls (n = 27) were also studied.Plasma was prepared from whole blood drawn on ICU admission (ICU day 1). Microvesicle tissue factor activity, thrombin-antithrombin complexes, D-dimers...
This study proposes Ni Micro-Plating Bonding (NMPB) as a new bonding method for semiconductor packages power devices with high heat resistance such SiC. NMPB enables at low temperatures (55°C) by using nickel plating, melting point metal. was conducted newly developed plating solution and lead frames chevron-shaped profile designed NMPB, the strength microstructure of bonded area were evaluated. As result, it found that exhibits stronger compared to conventional lead-free solder....
While the conventional understanding of haemostatic plug formation is that coagulation proceeds efficiently on surface activated platelets at vascular injury site to form a robust plug, this does not explain clinical reality platelet dysfunction results in mild bleeding phenotype, whereas disorders exhibit severe phenotypes, particularly deep tissues. Here, we introduce an vivo imaging method observe internal and subsequent mice report after bleeding, occurs primarily outside blood vessel...
Highly filled dielectric polymer nanocomposites with high constant nanoparticles (e.g., BaTiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) have promising application in many fields such as energy storage. The effectiveness of these to increase the and density resulting has already been demonstrated. However, role interface between matrix on thermal expansion, storage breakdown strength-the three parameters that are important for...
A heparin-modified thermoresponsive surface bound with heparin-binding epidermal growth factor-like factor (HB-EGF) was designed to allow creation of transferrable and functional hepatocyte sheets. prepared by covalently tethering heparin onto poly(
Interactions between muscle and bone have been recently noted. We reported that the vestibular system plays crucial roles in changes induced by hypergravity mice. However, details of mechanisms which gravity change affects through still remain unknown. Here, we investigated humoral factors linking to myostatin‐related hypergravity‐induced mice with lesions (VL). Hypergravity elevated serum mRNA levels follistatin, an endogenous inhibitor myostatin, soleus VL blunted hypergravity‐enhanced...
Abstract A new class of hydrogels utilizing DNA (DNA quadruplex gel) has been constructed by directly and symmetrically coupling deoxynucleotide phosphoramidite monomers to the ends polyethylene glycols (PEGs) in liquid phase, using resulting DNA‐PEG‐DNA triblock copolymers as macromonomers. Elongation merely four deoxyguanosine residues on PEG, which produces typically ≈10 grams desired DNA‐PEG conjugates one synthesis, resulted intelligent biodegradable formation, are responsive various...
Gene- or cell-based therapies aimed at creating delivery systems for coagulation factor VIII (FVIII) protein have emerged as promising options hemophilia A treatment. However, several issues remain to be addressed regarding the efficacies and adverse events of these new classes therapies. To improve an existing therapy involving subcutaneous transplantation FVIII-transduced blood outgrowth endothelial cells (BOECs), we employed a novel cell-sheet technology that allows individual dispersed...