A5080663291- Gout, Hyperuricemia, Uric Acid
- Pneumonia and Respiratory Infections
- Advanced MRI Techniques and Applications
- Bone Tumor Diagnosis and Treatments
- Alcohol Consumption and Health Effects
- Sarcoma Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Cerebrospinal fluid and hydrocephalus
- Oral and Maxillofacial Pathology
- Radiation Dose and Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Soft tissue tumor case studies
- Bone and Joint Diseases
- Respiratory and Cough-Related Research
- Musculoskeletal synovial abnormalities and treatments
- Antibiotic Resistance in Bacteria
- Diet, Metabolism, and Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Pediatric health and respiratory diseases
- MRI in cancer diagnosis
- Eosinophilic Disorders and Syndromes
- Vascular Malformations and Hemangiomas
- Advanced X-ray and CT Imaging
Teikyo University
2013-2025
Takamatsu Red Cross Hospital
2024
University of California, San Diego
2020-2022
Osaka City University
2020-2021
Tokyo Medical University
2021
Hyogo Medical University
2004-2018
Yamato Municipal Hospital
2003
Japan Women's University
1996-1997
Tokyo Polytechnic University
1995
Sapporo National Hospital
1985-1986
IVL is characterized by a propensity for intravascular tumor cell proliferation. Premortem diagnosis of difficult because its nonspecific clinical, laboratory, and imaging manifestations. This study examined cerebral MR patterns their changes with without chemotherapy. Nine 11 patients studied presented abnormal findings. We define 5 findings: 1) infarctlike lesions, 2) white matter 3) meningeal enhancement, 4) masslike 5) hyperintense lesions in the pons on T2WI. Seven only 1 pattern, while...
FR167653 was discovered as a cytokine production inhibitor, but its target molecule has remained unclear. We examined the effect of on activities purified protein kinases. dose dependently inhibited p38alpha mitogen-activated kinase activity without affecting other had no cyclooxygenase (COX)-1 or COX-2 activities, whereas SB203580 them. suppressed endogenous p38 in interleukin-1-stimulated NRK-F cells. These results indicate that is kinase-selective inhibitor COX activity. To evaluate role...
Clearance of cerebrospinal fluid (CSF) is important for the removal toxins from brain, with implications neurodegenerative diseases. Imaging evaluation CSF outflow in humans has been limited, relying on venous or invasive intrathecal injections contrast agents. The objective this study was to introduce a novel spin-labeling MRI technique detect and quantify movement endogenously tagged CSF, then apply it evaluate normal varying ages.
Purpose: Cerebrospinal fluid (CSF) clearance is essential for maintaining a healthy brain and cognition by removal of metabolic waste from the central nervous system. Physical exercise has been shown to improve human health; however, effect physical on intrinsic CSF outflow in humans remains unexplored. The purpose this study was investigate pathways quantitative metrics individuals with active sedentary lifestyles. In addition, investigated among subjects before after 3 weeks activity.
Objective: It has been demonstrated that uridine infusion induces insulin resistance in rats. Furthermore, it was recently reported plasma is correlated with homeostasis model assessment of (HOMA-R) hypertensive patients. Therefore, we investigated whether HOMA-R patients non-insulin-dependent diabetes mellitus (NIDDM). Subjects and Methods: The subjects were 23 male NIDDM (average age 63 years) 18 healthy males 60 years). Blood samples drawn after an overnight fast, then measured using...
As the outermost barrier of body, skin is a major target oxidative stress. In brain, estrogen has been reported synthesized locally and protects neurons from Here, we explored whether also in to protect stress aberrant local synthesis involved disorders. Enzymes receptor expression cells were examined first by quantitative real-time PCR Western blot analyses. Interestingly, enzyme was mainly localized epidermal keratinocytes receptors expressed melanocytes among 13 kinds cultured human...
Abstract We present a new, extremely rare nonmyxoid cellular variant of extraskeletal myxoid chondrosarcoma. Although diagnosis is radiologically and pathologically challenging, FDG PET/CT MRI accurately showed the malignancy high tumor density. A 52-year-old woman complained left dorsal mass, which presented inhomogeneous intermediate signals on T2-weighted images, with diffusion restriction, strong enhancement, increased accumulation (SUV max , 5.2). biopsy was inconclusive, highly...
Fresh blood imaging (FBI) utilizes physiological signal differences between diastole and systole, causing a long acquisition time. The purpose of this study is to develop fast FBI technique using centric k
The purpose of this study was to investigate the effect ovariectomy on osteoinductive activity in bone rat. Homograft implantation decalcified humeral diaphysis from ovariectomized or sham-operated rats performed and harvested after several time periods. A significant decrease induction found terms soft X-ray photography, alkaline phosphatase activity, mineral content expression osteocalcin (BGP; gla-protein) implants group comparison those animals. This result suggested that level probably...
Abstract: The presence of types alkaline phosphatase (ALP) other than the tissue non‐specific type enzyme in rat liver and its increase by fat feeding are known. In order to examine expression intestinal ALP liver, specific oligonucleotide primers corresponding two mRNAs (RTIN‐1 and‐2) were designed amplified means reverse transcriptase‐polymerase chain reaction (RT‐PCR). It was found that RTIN‐1 mRNA expressed only intestine but not while RTIN‐2 both liver. By feeding, increased Thus, it...
When treating gout patients, we have incidentally found elevated serum levels of adiponectin in some after administration benzbromarone. In the present study, determined whether benzbromarone increases level patients and investigated mechanism involved. Sixty-nine with were separated into two groups, then treated for 1 year uric acid-lowering therapy using or allopurinol. After overnight fasting, blood samples drawn before at beginning treatment. an vitro 3T3L1 cells incubated medium...
The clinical effectiveness and side effects of DL-8280 in the treatment lower respiratory tract infections including pneumonias were compared with those amoxicillin (AMPC) by a double-dummy fashion.The following diseases included this study; infectious exacerbation chronic bronchitis diffuse panbronchiolitis, (bronchiectasis, bronchial asthma, pulmonary emphysema, lung fibrosis, inactive tuberculosis) various kinds bacterial pneumonias.Two hundred mg dose was orally administered 3 times per...