A5087501111- Neuroscience of respiration and sleep
- Dysphagia Assessment and Management
- Respiratory Support and Mechanisms
- Neuroendocrine regulation and behavior
- Heart Rate Variability and Autonomic Control
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Sleep and Wakefulness Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Voice and Speech Disorders
- Infant Health and Development
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Child Nutrition and Feeding Issues
- Obstructive Sleep Apnea Research
- Ion channel regulation and function
- Esophageal and GI Pathology
- Adipose Tissue and Metabolism
- Olfactory and Sensory Function Studies
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Circadian rhythm and melatonin
- Intensive Care Unit Cognitive Disorders
- Ion Channels and Receptors
Hyogo University
2022-2025
Hyogo Medical University
2014-2024
Physiol (Belgium)
2023
Gifu University
2022
Ichikawa City Rehabilitation Hospital
2022
Suzuki (Japan)
2022
Hyogo Prefectural Awaji Medical Center
2021
Kyoto University
1992-2007
Yamaguchi University
2002
Kyoto University Hospital
1999-2002
Increases in the low attenuation areas (LAA) of chest x-ray computed tomography images patients with chronic obstructive pulmonary disease (COPD) have been reported to reflect development pathological emphysema. We examined statistical properties LAA clusters COPD and healthy subjects. In patients, percentage lung field occupied by LAAs (LAA%) ranged from 2.6 67.6. contrast, LAA% was always <30% The cumulative size distribution followed a power law characterized an exponent D . show that...
1. We examined the interaction between central pattern generators for respiration and deglutition in decerebrate, vagotomized, paralysed ventilated cats (n = 10), by recording activity from following nerves: hypoglossal, phrenic, thyroarytenoid triangularis sterni. Fictive breathing was spontaneous with carbon dioxide above apnoeic threshold (end‐tidal PCO2, 32 +/‐ 4 mmHg) fictive swallowing induced stimulating internal branch of left superior laryngeal nerve (SLN) continuously (0.2 ms pulse...
1. The behaviour of medullary respiratory neurons was studied during fictive coughing and swallowing evoked by electrical stimulation the superior laryngeal nerve (SLN) in decerebrate, paralysed artificially ventilated cats. Fictive coughing, respiration were monitored recording activities phrenic, hypoglossal abdominal nerves. 2. Extracellular recordings made from ventral group (VRG) Bötzinger complex (BOT). neuronal types analysed included decrementing inspiratory (I-DEC), augmenting...
Neuronal activity in the respiratory network is functionally dependent on inhibitory synaptic transmission. Using two-photon excitation microscopy, we analyzed integration of glycinergic neurons isolated inspiratory pre-Bötzinger complex-driven rhythmic slice preparation. Inspiratory (96%) and 'tonic' expiratory (4%) were identified via an increase or decrease, respectively, cytosolic free calcium concentration during inspiratory-related burst. Furthermore, BAC-transgenic mice expressing...
Recent research suggests that cognitive performance might be altered by the respiratory-synchronized activity generated in brain. Previous human studies, however, have yielded inconsistent results when assessing task during distinct respiratory phases (inspiratory phase vs. expiratory phase). We therefore tested whether was regulated based on timing of breathing components (e.g., expiratory-to-inspiratory (EI) transition) retrieval process. To determine role respiration performance, present...
The low attenuation areas on computed tomographic (CT) scans have been reported to represent emphysematous changes of the lung. However, regional distribution emphysema between inner and outer segments lung has not adequately studied. In this study compared by quantitative CT analysis contribution pulmonary function tests evaluated in patients with chronic obstructive disease (COPD).Chest images results were obtained from 73 COPD. divided into upper (cranial), middle, lower (caudal)...
Abstract The respiratory rhythm is generated and regulated by a neuronal network within the lower brainstem. While mechanisms of generation have been extensively investigated, contribution glial cells remains to be determined. Here we report effect specific blockade Krebs cycle glutamine synthetase on activity network. Application 5 m fluoroacetate, which selectively blocks cycle, suppressed rhythmic burst activity. Substitution either substrate isocitrate (3 ) or restored Blockade...
The neural inspiratory activity originates from a ventrolateral medullary region called the pre-Bötzinger complex (preBötC), yet mechanism underlying respiratory rhythmogenesis is not completely understood. Recently, role of only neurons but astrocytes in central control has attracted considerable attention. Here we report our discovery that an intracellular calcium rise subset putative precedes neuronal firing rhythmically active slices. Functional imaging hundreds preBötC cells revealed...
Rationale: Swallowing during inspiration and swallowing immediately followed by increase the chances of aspiration may cause disease exacerbation. However, mechanisms which such breathing-swallowing discoordination occurs are not well-understood. Objectives: We hypothesized that when timing swallow in respiratory cycle is inappropriate. To test this hypothesis, we monitored respiration activity healthy subjects patients with dysphagia using a non-invasive monitoring system. Measurements Main...
<h3>Introduction</h3> Impaired coordination between breathing and swallowing (breathing–swallowing discoordination) may be a significant risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). We examined breathing–swallowing discoordination in patients with COPD using non-invasive quantitative technique determined its association exacerbation. <h3>Methods</h3> recruited 65 stable outpatients who were enrolled our prospective observational cohort study did not...
The nucleus tractus solitarius (NTS) contains neurons that relay sensory swallowing commands information from the oropharyngeal cavity and premotor of dorsal group (DSG). However, spatio-temporal dynamics interplay between DSG is not well understood. Here, we employed fluorescence imaging after microinjection calcium indicator into NTS in an arterially perfused brainstem preparation rat (n = 8) to investigate neuronal population activity response superior laryngeal nerve (SLN) stimulation....
The assessment of swallowing function is important for the prevention aspiration pneumonia. We developed a new monitoring system that uses respiratory flow, sound, and laryngeal motion. applied this device to 11 healthy volunteers 10 patients with dysphagia. Videofluoroscopy (VF) was conducted simultaneously using our device. measured rising time (LRT), required larynx elevate highest position, activation duration (LAD), between onset rapid elevation when returned lowest position. In...
The purpose of this study was to test the hypothesis that risk silent aspiration is increased in non-invasive positive pressure ventilation.We analysed coordination between respiration and swallowing, 12 young volunteers 10 elder volunteers, by simultaneously monitoring respiratory flow, laryngeal movement swallowing sound three different conditions: control, continuous airway (CPAP), bi-level (BiPAP). A step-wise multiple regression analysis performed with occurrence rate inspiration after...
Two putative respiratory rhythm generators (RRGs), the para-facial group (pFRG) and pre-Bötzinger complex (preBötC), have been identified in neonatal rodent brainstem. To elucidate their functional roles during period, we evaluated developmental changes of these RRGs by optical imaging using a voltage-sensitive dye. Optical signals, recorded from ventral medulla brainstem-spinal cord preparations (P0-P4) rats (n = 44), were analysed cross correlation method. With development first few...
The pontine respiratory group (PRG) facilitates the mechanism for terminating inspiratory phase but may influence other phases in cycle as well. We determined effects of PRG lesions on response to superior laryngeal nerve stimulation delivered each decerebrate, vagotomized, paralyzed, and ventilated cats (n = 6). measured duration inspiration (TI) expiration (TE) three breaths before perturbed breath TI after perturbation. delay next was plotted against at which stimulus delivered. Before...
Spontaneous breathing occurs transiently in spinalized animals suggesting that the cervical spinal cord generates respiratory rhythm. We recorded optical signals from isolated brainstem–spinal preparations of neonatal rats using a voltage-sensitive dye, and visualized respiratory-related activity by processing data with correlation coefficient imaging technique. identified novel region extended medullo-spinal junction to C2 segment, approximately 100–300 μm deep ventral surface, termed high...
Background: The wide use of herbal plants and essential oils for the prevention treatment diseases dates back to ancient times. However, scientific basis beneficial effects such has not been precisely clarified. Objective: purpose this study was evaluate aromatherapy body on healthy subjects. Design: We compared physiologic psychologic (E), massage with carrier oil alone (C), rest in adults. Subjects: Seven (7) female 6 male volunteers participated as Interventions: Each subject underwent 3...