A5081222851- Urinary Tract Infections Management
- Viral gastroenteritis research and epidemiology
- Antibiotic Resistance in Bacteria
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Urinary Bladder and Prostate Research
- RNA Interference and Gene Delivery
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Respiratory viral infections research
- Cancer Immunotherapy and Biomarkers
- Bacteriophages and microbial interactions
- Bladder and Urothelial Cancer Treatments
- Pediatric Urology and Nephrology Studies
- Antibiotics Pharmacokinetics and Efficacy
- Hepatitis C virus research
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
- Virus-based gene therapy research
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Vibrio bacteria research studies
- Enterobacteriaceae and Cronobacter Research
Kobe University
2016-2025
Himeji Medical Center
2025
Okayama University Hospital
2023
Nagoya University Hospital
2021
Kobe International University
2020
Osaka University
2019
Kobe University Hospital
2017
Tokyo Women's Medical University
2009-2013
Nagoya University
2011
Shionogi (Japan)
1988
The value of the hepatobiliary phase gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) in patients with hepatocellular carcinoma (HCC) has not been evaluated detail.Between 2008 and 2009, 61 HCC within Milan criteria underwent Gd-EOB-DTPA-enhanced MRI hepatectomy. tumor margin was determined preoperatively based on images. Microscopic portal vein invasion (MPVI), intrahepatic metastasis (IM), recurrence 1 year after hepatectomy were 24 non-smooth margins at...
Antimicrobial stewardship teams (ASTs) have been well-accepted in recent years; however, their clinical outcomes not fully investigated urological patients. The purpose of this study was to evaluate the intervention via a retrospective review patients, as discussed AST meetings, who were treated with broad-spectrum antibiotics between 2014 and 2018 at Department Urology, Kobe University Hospital Japan. Interventions meetings for patients identified by pharmacists having received...
Cancer immunotherapy using antigen-pulsed dendritic cells can induce strong cellular immune responses by priming cytotoxic T lymphocytes. In this study, we pulsed tumor cell lysates with VP-R8, a cell-penetrating D-octaarginine-linked co-polymer of N-vinylacetamide and acrylic acid (PNVA-co-AA), into the DC2.4 murine line to improve antigen uptake then determined anti-tumor effect in tumor-bearing mice. were lysate EL4, lymphoma line, VP-R8 generate vaccine. For vivo EL4 subcutaneously...
Tumor-associated macrophages (TAMs) and microvessel density (MVD) play an essential role for tumor progression in prostate cancer (PCa). In this study, we evaluated the association between TAMs, infiltration with angiogenesis response to androgen deprivation therapies (ADTs) PCa evaluate TAM as a predictive factor survival. Fifty-four specimens were collected stained CD 68 antibody investigated tumor. Von Willebrand was MVD around foci. We assessed patient's age, preoperative serum...
Abstract Recently, immune checkpoint inhibitor (ICI) based combination therapies, including anti-PD-1 antibody, nivolumab with anti-CTLA-4 and ipilimumab have become the primary treatment option for metastatic or unresectable renal cell carcinoma (RCC). However, despite of two ICIs, 60–70% patients are still resistant to first-line cancer immunotherapy. In present study, undertook immunotherapy RCC using an oral vaccine ( Bifidobacterium longum displaying WT1 tumor associated antigen B....
The SWItch Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, which includes components such as SMARCA4 and SMARCA2, regulates gene expression by controlling compaction accessibility in an ATP-dependent manner. These are also implicated carcinogenesis. Thoracic SMARCA4-deficient undifferentiated tumor is a recently introduced category the fifth edition of WHO classification 2021, typically exhibiting rhabdoid morphology adults. In contrast, tumors occurring within abdominal...
Abstract Muscle-invasive bladder cancer (MIBC), a highly heterogeneous disease, shows genomic instability and high mutation rate, making it difficult to treat. Recent studies revealed that stem cells (CSCs) play critical role in MIBC frequent recurrence morbidity. Previous research has shown Cyclooxygenases-2 (COX-2) is particularly expressed cells. In recent years, the development of oncolytic adenoviruses their use clinical trials have gained increased attention. this study, we composed...
Background Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry ( MALDI ‐ TOF MS ) contributes to rapid identification of pathogens in the clinic but has not yet performed especially well for Gram‐positive cocci (GPC) causing complicated urinary tract infection UTI ). The goal this study was investigate possible clinical use as a method bacterial directly from urine . Methods applied samples gathered 142 suspected patients 2015‐2017. We modified standard procedure...
Abstract Studies on the aberrant control of extracellular matrices (ECMs) have mainly focused role malignant cells but less that stromal fibroblasts during cancer development. Herein, by using paired normal and prostate cancer-associated (CAFs) derived from a coculture cell model clinical patient samples, we demonstrated although CAFs promoted growth, matrix metalloproteinase-3 (MMP-3) was lower in elevated relative to their counterparts. Furthermore, hydrogen peroxide characterized as...
Abstract Previously, we constructed a recombinant Bifidobacterium longum displaying partial mouse Wilms' tumor 1 (WT1) protein (B. 420) as an oral cancer vaccine using bacterial vector and demonstrated that administration of B. 420 significantly inhibited growth compared with the Db126 WT1 peptide in TRAMP-C2, castration-resistant prostate (CRPC) syngeneic model. The present study 1.0×109 colony-forming units induced higher cytotoxicity against TRAMP-C2 cells than intraperitoneal injection...
Variation by country in urinary tract infection (UTI)-causative bacteria is partly due to the differences use of antibiotics. We compared their frequencies and antibiotic susceptibilities treatment patients with UTI from 2 cities, Kobe, Japan, Surabaya, Indonesia. retrospectively analyzed 1,804 urine samples collected 2014 (1,251 11 months at Kobe University Hospital 544 Dr. Soetomo Surabaya). Surabaya data were divided into adult pediatric because a substantial number specimens...
Despite the revolutionary progress of immune checkpoint inhibitors (CPIs) for cancer immunotherapy, CPIs are effective only in a subset patients. Combining and vaccines to achieve better clinical outcomes is reasonable approach since CPI enhances vaccine-induced tumor-associated antigen (TAA) specific CTL. Among various TAAs so far identified, WT1 protein one most promising as vaccine target. Until now trials have demonstrated modest efficacy. These were based on peptides or dendritic cells...
The incidence of bacteremia caused by Enterococcus faecium, which is highly resistant to multiple antibiotics, increasing in Japan. However, risk factors for the acquisition E. faecium infection and mortality due enterococcal are not well known. We compared demographic, microbiological, clinical characteristics using a Cox regression model univariate analysis. performed multivariate analysis identify patients treated between 2014 2018. Among 186 with bacteremia, two groups included...
Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) such as PD-1/PD-L1 has been well established for various types of cancer. Monotherapy with ICIs, however, can achieve a durable response in only subset patients. There is great unmet need the ICI-resistant-tumors. Since patients who respond to ICIs should have preexisting antitumor T cell response, combining cancer vaccines that forcibly induce an reasonable strategy. However, preferred administration sequence combination and...
Phase I clinical studies of 7432‐S, a new oral cephalosporin, including randomized placebo‐controlled trial were conducted with 40 healthy volunteers, in single‐dose studies, 7432‐S was orally administered at doses 25, 50, 100, and 200 mg. The mean plasma levels peaked 2.1 to 3.0 hours reached 1.9, 3.6, 5.6, 11.6 μg/ml, respectively. Linear correlation observed between AUC values given. half‐lives the 0.88 2.26 1.53 ± 0.33 hours. urinary recoveries 67.5 75.2% dose within 24 partially...
Antimicrobial agents are administered to humans and livestock, bacterial antimicrobial resistance (AMR) released into the environment. In this study, investigate trend of AMR in humans, environment, we performed a metagenomic analysis multidrug-resistant bacteria with CHROMagar ESBL environmental river water samples, which were collected using syringe filter units from waters near hospitals, downtown areas, residential treatment plants Surabaya, Indonesia. Our results showed that