A5029337185- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Cardiac Arrhythmias and Treatments
- Sodium Intake and Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Healthcare cost, quality, practices
- Disaster Response and Management
- Hemodynamic Monitoring and Therapy
- Cardiovascular and exercise physiology
- Cardiovascular Health and Disease Prevention
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Pregnancy and preeclampsia studies
- Shoulder Injury and Treatment
- Safety and Risk Management
- Birth, Development, and Health
- Restless Legs Syndrome Research
- Gastrointestinal motility and disorders
- Gestational Diabetes Research and Management
- Adrenal and Paraganglionic Tumors
University of Alberta
1992-2022
University of British Columbia
2008-2010
Vancouver General Hospital
2006
Health Sciences Centre
2004
Sunnybrook Health Science Centre
2004
University of Alberta Hospital
1990-1996
Alberta Hospital Edmonton
1996
Shaughnessy Hospital
1985-1988
Queen's University
1976-1983
Reasons for an increase in maximal O2 consumption (VO2max) following blood reinfusion remain unclear; thus the present investigation was undertaken to examine arterial and femoral venous gases during submaximal exercise. Four untrained males (22–25 yr) performed modified Balke work capacity tests under control conditions (Hct = 42.4 +/- 0.8%; Hb 14.7 0.5 g X 100 ml-1) autologous 46.2 1.3%; 16.4 0.9 ml-1). VO2 determined by open-circuit spirometry cardiac output N2O method; radial deep were...
Six patients between the ages of 25 and 59, with chronic, primary insomnia received new, non-benzodiazepine, hypnotic zopiclone continuously for 17 weeks after a drug free interval 12 nights. To qualify study, sleep efficiency, determined by study on two, consecutive, placebo-controlled nights, had to be less than 75%. Patients evaluated their questionnaire studies completed throughout active treatment. Zopiclone (7.5 mg) increased efficiency decreasing latency, wakefulness onset increasing...
To determine the relationship between central blood pressure (CBP) indices and mild cognitive impairment (MCI) in adults over age of 50.A cross-sectional study conducted using a non-invasive SphygmoCor XCEL device. CBP brachial were measured 50 inpatients outpatients. MCI was assessed Montreal Cognitive Assessment (MoCA) instrument by European Consortium Criteria (ECC).Seventy-six percent subjects had hypertension, 52% diagnosed as having ECC. No significant association found any variables...
The chiral β‐blocker, Sotalol (STL), is marketed as a racemic mixture. Although both STL enantiomers have equal Class III antiarrythmic activity, β‐blocking activity has been ascribed mainly to the R‐enantiomer. pharmacokinetics of were studied in young (mean age 32 ± 3 years), healthy male volunteers after oral administration 160 mg. Subsequent plasma and urine samples collected over 24 hours, enantiomer concentrations determined using stereospecific high‐performance liquid chromatography...
We investigated the effect of high-frequency oscillation (HFO) on lung lymphatic function under normal conditions and when lymph flow was increased by air microembolization. In six experiments, sheep goats with chronic fistulas vascular catheters were anesthetized, paralyzed, intubated, ventilated according to following protocol: 1) intermittent positive-pressure ventilation (IPPV) for 1 h, 2) HFO a frequency 15 Hz an estimated tidal volume 1-2 ml/kg 3) IPPV 0.5 h. Ventilator settings...
Background: While warfarin is efficacious for the prevention of thromboembolic disorders, many patients are undertreated. To optimize therapy, anticoagulation management services (AMSs) deliver a coordinated, focused approach to this care; however, AMSs limited in their ability impact outside tertiary care settings. Objective: describe methods used develop community-based across Alberta. Methods: Through three-staged approach, project created community-based, pharmacist-managed requiring...
Fifty-four patients (34 outpatients, 20 inpatients)fulfilling Research Diagnostic Criteria for Definite Major Depressive Disorder were enrolled in a double-blind study comparing the antidepressant effects of alprazolam versus desipramine. The mean daily dose and desipramine at termination was 3.78mg 208mg respectively. As there no significant demographic or clinical differences between outpatients inpatients, both groups combined data analysis. Using Hamilton Depression Rating Scale (HAM-D)...
Background: Orthostatic hypotension (OH) is associated with falls and cardiovascular events. There growing evidence that central blood pressure (CBP) better than peripheral (PBP) in predicting adverse outcomes. The objectives of this study were to assess 1) the prevalence OH identified using PBP CBP levels agreement, 2) respective associations between comorbidities, by CBP, 3) association arterial wall stiffness markers (augmentation (AP) augmentation index (AI)). Methods: An observational...
Lewanczuk RZ, Hamilton PC. Parathyroid hypertensive factor predicts efficacy in the treatment of essential hypertension with verapamil.Parathyroid (PHF) is a circulating factor, levels which are inversely related to renin profile. Given this relationship, it was hypothesized that PHF level might serve as an alternate predictor antihypertensive patients, avoiding difficulties associated profiling. To test hypothesis, thirty patients were placed on 240 mg once daily slow release verapamil...