A5079724107- Drug Transport and Resistance Mechanisms
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Signaling Pathways in Disease
- Pharmacogenetics and Drug Metabolism
- Inflammatory mediators and NSAID effects
- Fermentation and Sensory Analysis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Diabetes Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Oral and gingival health research
- Anesthesia and Sedative Agents
- Drug Solubulity and Delivery Systems
- Pancreatic function and diabetes
- Renal Transplantation Outcomes and Treatments
- Horticultural and Viticultural Research
- Postharvest Quality and Shelf Life Management
- Advanced Chemical Sensor Technologies
- Receptor Mechanisms and Signaling
- HIV Research and Treatment
- Hops Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Meat and Animal Product Quality
Edison Pharmaceuticals (United States)
2017-2025
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Molson Coors Brewing Company (United States)
2021
Scripps Research Institute
2019
Desert Springs Hospital
2014
University of Alberta
1994-2008
Lynde Centre for Dermatology
2008
Health Sciences Centre
2008
The 2-arylpropionic acid nonsteroidal anti-inflammatory drugs are usually administered as racemates. enantiomers may have different pharmacokinetics and the R-isomer metabolically invert to S-isomer. To pinpoint kinetics of inversion location in which this metabolic process takes place, racemic ketoprofen (KT) was rat. Using a stereospecific HPLC assay, KT were studied following 10 mg/kg iv, po, ip doses male Sprague-Dawley rats. Plasma concentrations always greater for (S)-KT than (R)-KT....
Previous studies show that cyclophilins contribute to many pathologic processes, and cyclophilin inhibitors demonstrate therapeutic activities in experimental models. However, no drug with inhibition as the primary mode of action has advanced completely through clinical development market. In this study, we present findings on inhibitor, CRV431, highlight its potential a candidate for chronic liver diseases. CRV431 was found potently inhibit all isoforms tested—A, B, D, G. Inhibitory...
Cyclophilins are a diverse family of peptidyl-prolyl isomerases (PPIases) importance in variety essential cellular functions. We previously reported that the pan-cyclophilin inhibitor drug reconfilstat (CRV431) decreased disease mice under western-diet and carbon tetrachloride (CCl 4 ) non-alcoholic steatohepatitis (NASH) model. CRV431 inhibits several cyclophilin isoforms, among which A (CypA) B (CypB) most abundant. It is not known whether simultaneous inhibition multiple members necessary...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAging of hops and their contribution to beer flavorKai C. Lam, Robert T. Foster II, Max L. DeinzerCite this: J. Agric. Food Chem. 1986, 34, 4, 763–770Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/jf00070a043https://doi.org/10.1021/jf00070a043research-articleACS PublicationsRequest reuse permissionsArticle Views1245Altmetric-Citations67LEARN ABOUT...
Hepatitis B virus (HBV) infection is a major health burden worldwide with 240 million chronically infected individuals. Nucleos(t)ide analogs and interferons are the current standards of care due to their suppression HBV replication, but treatments rarely eradicate from Similar for human immunodeficiency type-1 (HIV-1) hepatitis C (HCV) patients, improved therapies will require combination multiple drugs which target distinct steps life cycle. In this study, we tested potential cyclophilin...
Abstract Rencofilstat (RCF) demonstrated antifibrotic effects in preclinical models and was safe well tolerated Phase 1 studies. The aim of this 2a study safety, tolerability, pharmacokinetics, exploration efficacy biomarkers subjects with nonalcoholic steatohepatitis (NASH). This 2a, multicenter, single‐blind, placebo‐controlled randomized 49 presumed F2/F3 to RCF 75 mg once daily (QD), 225 QD, or placebo for 28 days. Primary safety tolerability endpoints were explored using descriptive...
ABSTRACT Background and Aims Rencofilstat inhibits cyclophilin to reduce hepatic inflammation fibrosis, which, in turn, could improve liver function portal‐systemic shunting. Since HepQuant quantifies shunting, it was used measure the effects of rencofilstat treatment MASH with advanced fibrosis. Methods Seventy subjects suspected ≥ F3 MASH, defined from biopsy or AGILE 3+ 0.53, were randomised 75 mg/d ( n = 24), 150 23) 225 23), tested by at baseline, 60 120 days. The DuO version included...
HCV-related liver disease is the main cause of morbidity and mortality HCV/HIV-1 co-infected patients. Despite recent advent anti-HCV direct acting antivirals (DAAs), treatment patients remains a challenge, as these are refractory to most therapies develop fibrosis, cirrhosis cancer more often than HCV mono-infected Until present study, there was no suitable in vitro assay test inhibitory activity drugs on co-infection. Here we developed novel "co-infection" model where HIV-1 concurrently...
A family of Peptidyl-prolyl isomerases (PPIases), called Cyclophilins, localize to numerous intracellular and extracellular locations where they contribute a variety essential functions. We previously reported that non-immunosuppressive pan-cyclophilin inhibitor drugs like reconfilstat (CRV431) or NV556 decreased multiple aspects non-alcoholic fatty liver disease (NAFLD) in mice under two different steatohepatitis (NASH) mouse models. Both CRV431 inhibit several cyclophilin isoforms, among...
The peroral (po) bioavailability of nifedipine is reported to range from about 45 58% in the rat; this compares favourably human beings. metabolism similar rats and humans (oxidation dihydropyridine ring), with liver believed be solely responsible for systemic clearance drug observed first-pass effect after po dosing. purpose study was determine whether intestinal also contributes elimination rat. availabilities doses given by po, intracolonic (ic), intraperitoneal (ip) routes administration...