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Bruce Daugherty

ORCID: 0000-0003-2875-3920
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About
Contact & Profiles
A5021948958
Research Areas
  • Renal Transplantation Outcomes and Treatments
  • Complement system in diseases
  • T-cell and B-cell Immunology
  • Viral Infections and Immunology Research
  • Transplantation: Methods and Outcomes

Tonix Pharmaceuticals (United States)
 2023

Eloxx Pharmaceuticals (United States)
 2023

 TNX-1500, a crystallizable fragment–modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival
OPENALEX - Publications 
Grace Lassiter Ryo Otsuka Takayuki Hirose Ivy A. Rosales Ahmad Karadagi and 16 more Toshihide Tomosugi Abbas Dehnadi Hang Lee Robert B. Colvin Jason Baardsnes Anna N. Moraitis Emma E. Smith Zahida Ali Phil Berhe Andrew T. Mulder Bernd Meibohm Bruce Daugherty Siobhan Fogarty Richard N. Pierson Seth Lederman Tatsuo Kawai

10.1016/j.ajt.2023.03.022 article EN cc-by-nc-nd American Journal of Transplantation 2023-04-04
 TNX-1500, a crystallizable fragment–modified anti-CD154 antibody, prolongs nonhuman primate cardiac allograft survival
OPENALEX - Publications 
Shuhei Miura Zahra Habibabady Franziska Pollok Madelyn Ma Ivy A. Rosales and 9 more Kohei Kinoshita Shannon Pratts Gannon McGrath Ryan Chaban Siobhan Fogarty Bernd Meibohm Bruce Daugherty Seth Lederman Richard N. Pierson

Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to supplement or replace current clinical immunosuppression in solid organ transplantation. We evaluated tolerability and activity novel humanized anti-CD154 monoclonal antibody, TNX-1500 (TNX), nonhuman primate heterotopic cardiac allogeneic (allo) transplant model. contains rupluzimab fragment antigen-binding region an immunoglobin G4 crystallizable engineered reduce binding gamma receptor IIa associated risks...

10.1016/j.ajt.2023.03.025 article EN cc-by-nc-nd American Journal of Transplantation 2023-04-07
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