A5089621987- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- Diabetic Foot Ulcer Assessment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- X-ray Diffraction in Crystallography
- Nausea and vomiting management
- Circular RNAs in diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Facial Rejuvenation and Surgery Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Neurotoxicity Research
- Dermatologic Treatments and Research
- Crystallization and Solubility Studies
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Injury Epidemiology and Prevention
- Surgical site infection prevention
- Mesenchymal stem cell research
- 14-3-3 protein interactions
- Scheduling and Timetabling Solutions
Nanchang University
2016-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
First Affiliated Hospital of Nanchang University
2015-2024
Fujian University of Traditional Chinese Medicine
2023-2024
Institute for Forecasting of the Slovak Academy of Sciences
2023
Cytoskeleton (United States)
2023
Fujian Provincial Hospital
2023
Fujian Medical University
2021-2023
Christie's
2018
Metformin, a biguanide, exerts different functions through various signaling pathways. In order to investigate the function and mechanism of metformin in burn wounds, we established rat models, subcutaneously injected treat observed morphologies expression collagen I, III, fibronectin, pro-inflammatory markers. vitro experiments were performed effects on proliferation, migration, I synthesis mouse embryonic fibroblast (NIH 3T3) cell line apoptosis, immune response mononuclear macrophage (RAW...
The aim of the present study was to investigate effect epidermal growth factor (EGF) and acidic fibroblast (aFGF) on healing diabetic foot wounds. A total 199 patients with ulcers were recruited randomly divided into four groups: recombinant human EGF group (n=50), an aFGF a combined (n=50) normal saline control (n=49). Patients in all groups received daily dressing change reagents applied topically when dressing. To observe time required for each stage wound healing, rate granulation tissue...
Smoke inhalation injury is an acute pathological change caused by thermal stimulation or toxic substance absorption through respiratory epithelial cells. This study aims to probe the protective effect and mechanism of recombinant human keratinocyte growth factor 2 (rhKGF-2) against smoke inhalation-induced lung (SILI) in rats. The SILI was induced rats using a exposure model, which were then treated with rhKGF-2. rat blood collected for blood-gas analysis, levels inflammatory factors...
The prevalence of diabetic foot ulcers (DFUs) has caused serious harm to human health. To date, a highly effective treatment is lacking. Long noncoding RNA X-inactive specific transcript (lncRNA XIST) been the subject mounting research studies, all which have found that it serves as protective factor against certain diseases; however, its function in DFUs not entirely understood. This study was performed determine importance lncRNA XIST pathogenesis and biological DFUs. Diabetic ulcer skin...
Abstract Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with remains elusive. We examined in indicators outcomes at both transcriptomic clinical characteristic levels. At level, we pinpointed 28 differentially expressed coagulation-related genes (DECRGs) following burn injuries endeavored validate their causal relationships through Mendelian randomization....
Introduction Systemic lidocaine may reduce pain intensity and accelerate postoperative recovery. However, the efficacy of systemic in cognitive function has not been established. This study protocol is designed to clarify effectiveness delirium (POD) elderly patients scheduled for elective laparoscopic colorectal surgery. Methods analysis a prospective, multicentre, randomised, double-blind, parallel-group, placebo-controlled trial. One thousand twenty will be randomly allocated ratio 1:1...
<title>Abstract</title> Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with remains elusive. We examined in indicators outcomes at both transcriptome clinical characteristic levels. At transcriptional level, we pinpointed 28 differentially expressed coagulation-related genes (DECRGs) following burn injuries endeavored validate their causal relationships...
Acute pulmonary and systemic inflammation induced by smoke inhalation is crucial to the outcome complications of burn patient, immune dysfunction implicated in development organ injury. To reveal cytokines change cell interactions helpful know response following We were analyzing hematoxylin-eosin (HE) staining lung tissues Smoke mouse model, detect cytokine expression after 2,6,24,48,72 hours The Real-Time qPCR. Flow cytometry was used identify DC cells, T cells spleen, bone marrow...
Burns are a global public health problem. Major burns can stimulate the body to enter stress state, thereby increasing risk of infection and adversely affecting patient's prognosis. Recently, it has been discovered that cuproptosis, form cell death, is associated with various diseases. Our research aims explore molecular clusters cuproptosis in major construct predictive models. We analyzed expression immune infiltration characteristics cuproptosis-related factors burn based on GSE37069...
Purpose: Intravenous regional anesthesia (IVRA) using lidocaine provides effective localized analgesia but its duration is limited.The mechanism by which dexmedetomidine enhances IVRA unclear may involve modulation of hyperpolarizationactivated cyclic nucleotide-gated (HCN) channels.Materials and Methods: Lidocaine with varying concentrations was performed in the tails Sprague-Dawley rats.Tail-flick tail-clamping tests assessed efficacy duration.Contributions α 2 adrenergic receptors HCN...
The aim of the present study was to determine effects early anticoagulation treatment on severe burns complicated by inhalation injury in a rabbit model. Under anesthetization, an electrical instrument (100˚C) used scald backs rabbits for 15 sec, which established 30% III Treatment with effectively improved injury‑induced lung injury, reduced PaO2, PaCO2 and SPO2 levels, suppressed expression tumor necrosis factor‑α, interleukin (IL)‑1β IL‑6, increased activity IL‑10. In addition, it found...
The formation mechanism of chronic refractory wounds is complex, which a difficult problem to be solved. Effective classification and systematic evaluation are great significance guide clinical practice. Combining with domestic foreign wounds’clinical basic research, the review given etiology, system assessment wounds. aims build for diagnosis treatment wounds, lays solid foundation in order further carry out has good practical value. Key words: Wounds injuries; Diagnosis,...
: Recently high-frequency electric knife and abdominal binder are widely used in the operation China. Nevertheless, with high occurrence of wound, we think that whether both these operations could be or not. Here, report case a 40-year-old female patient where negative pressure wound therapy (NPWT) was applied to her dehisced as well fat liquefaction large skin necrosis pleasing results. The fever referred our department from earlier hospital for 6 days after cesarean delivery. During...
Background Dexmedetomidine enhances the quality and duration of lidocaine intravenous regional anaesthesia (IVRA). However, two administration routes have not been directly compared regarding effects on tourniquet tolerance time with IVRA. Additionally, it remains unclear whether prolonged stems from direct peripheral action dexmedetomidine or indirect systemic analgesic effects.
Objective: To compare the tissue morphology and gene expressions of inflammatory repair-related factors in chronic refractory wound including pressure ulcers diabetic feet. Methods: During August 2016 to September 2017, 10 samples prepuce were collected after circumcision urological patients [all male, aged (38±4) years old] admitted First Affiliated Hospital Nanchang University included normal skin group, around edge wounds with blood supply from 9 heat or electric burn [6 male patients, 3...
To study the potential expression of lung long non-coding RNAs (lncRNAs) and mRNAs during smoke inhalation injury (SII), using a SII mouse model that we created in our previous work. Microarray was used to investigate lncRNAs profiles. A bioinformatics analysis performed. Changes top 10 down-regulated up-regulated were validated Quantitative Reverse Transcription-PCR (RT-qPCR). The acute (ALI) successfully induced by inhalation, as confirmed aberrantly modified cell numbers red blood cells...