A5100435756- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Infectious Aortic and Vascular Conditions
- Atherosclerosis and Cardiovascular Diseases
- Acute Myeloid Leukemia Research
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory mediators and NSAID effects
- Vascular Procedures and Complications
- Acute Lymphoblastic Leukemia research
- Congenital Heart Disease Studies
- Autophagy in Disease and Therapy
- Childhood Cancer Survivors' Quality of Life
- Peripheral Artery Disease Management
- Cholesterol and Lipid Metabolism
- Burn Injury Management and Outcomes
- Renal and Vascular Pathologies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Chronic Myeloid Leukemia Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Affiliated Hospital of Nantong University
2024
Nantong University
2024
First Hospital of China Medical University
2013-2023
China Medical University
2013-2023
Dalian Medical University
2022
First Affiliated Hospital of Dalian Medical University
2022
Shenyang Center for Disease Control and Prevention
2021
Xiangya Hospital Central South University
2020
Central South University
2020
The development of effective pharmacological treatment abdominal aortic aneurysm (AAA) potentially offers great benefit to patients with preaneurysmal dilation by slowing the expansion aneurysms and reducing need for surgery. To date, therapeutic targets have had low efficacy. Thus, in this study, we aim elucidate possible mechanisms driving progression identify potential intervention. We demonstrate that mechanistic target rapamycin (mTOR) signaling is overactivated smooth muscle cells...
Abstract: Abdominal aortic aneurysms (AAA) is a multifactorial vascular disease with high rate of mortality and brings heavy burden to both human society. The pathological process behind AAA complex. Elastin degradation, chronic inflammation, smooth muscle cell phenotypic modulation are involved in formation. Apigenin (API) has gained much attention due its specific properties, such as anti-inflammation, antioxidant, anti-cancer effects. Previous studies have demonstrated that API exert...
ZNF384 rearrangements are found in 5-10% of B-cell acute lymphoblastic leukemia (B-ALL) and 48% B cell/myeloid mixed phenotype (B/M MPAL). ZNF384-rearranged B-ALL is prone to lineage conversion after chemotherapy. TCF3 the second most common rearrangement partner (27.5%) B/M MPAL (53.3%). TCF3-ZNF384 fusion related a poor steroid response high frequency relapse. It mostly reported children adolescents but rarely seen adults.Here, we report rare case adult with which patient relapsed one...
SET-CAN/NUP214 fusion is a recurrent event most commonly seen in T-cell acute lymphoblastic leukemia (T-ALL). It related to resistance glucocorticoids and chemotherapy; however, the reported prognosis of T-ALL with diverse, optimal treatment option remains undetermined. Here, we present process an illuminating case fusion. The patient showed early routine VICLP chemotherapy (at 15 th day, 79.2% blasts), but burden was significantly reduced after 28-day induction (18.85% even though she still...
<title>Abstract</title> Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with remains elusive. We examined in indicators outcomes at both transcriptome clinical characteristic levels. At transcriptional level, we pinpointed 28 differentially expressed coagulation-related genes (DECRGs) following burn injuries endeavored validate their causal relationships...
Abdominal aortic aneurysm (AAA) is life-threatening, its natural course progressively sac expansion and rupture. Elegant studies have been conducted to investigate the molecular markers associated with AAA growth expansion, this topic however, still needs be further elucidated. This study aimed identify potential genes for based on comprehensive bioinformatics approaches. Firstly, 29 up-regulated were identified through DEGs analysis between large small in GSE57691. Secondly, signed WGCNA...
Background: Obstructive sleep apnoea (OSA) is highly prevalent in patients with Stanford type B aortic dissection (TBAD). Few studies have evaluated the effects of OSA on vascular changes TBAD patients. This study aimed to explore effect morphological and its relation late events (LAEs). Methods: case-control included 143 The diameters different parts aorta were measured based computed tomography angiography (CTA). According apnoea-hypopnoea index (AHI), was classified as mild (5 ≤ AHI 15),...
Abstract Abdominal aortic aneurysms(AAA) is a life-threatening disease and the incidence of AAA still on rise in recent years. Numerous studies suggest dietary moderate consumption polyphenol exert beneficial effects cardiovascular disease. Apigenin(API) promising possesses potent our body. Although previous study revealed protective API experimental formation, up till now few were carried out to further investigate its involved molecular mechanisms. In present study, network pharmacology...
Endovascular treatment of abdominal aortic aneurysm (AAA) has been in use for several decades and become the main this disease. Iliac branch occlusion (IBO) is a common complication after endovascular treatment. The diagnosis guidance contrast-enhanced ultrasound (CEUS) combined with computed tomography angiography (CTA) recurrent IBO repair (EVAR) are rarely reported. In case, CEUS gave important hints on cause IBO.We present 67-year-old male patient who was diagnosed AAA 2020 underwent...