Intra-abdominal candidiasis (IAC) is a prominent invasive fungal infection associated with high mortality. Prompt antifungal therapy and source control are crucial for successful treatment. Echinocandin drugs first-line agents; however, their clinical effectiveness highly variable, known potential breakthrough resistance, little about drug exposure at the site of infection. Using matrix-assisted desorption ionization mass spectrometry imaging technology, we investigated spatial quantitative...

Resveratrol (RES) has antioxidative, anti-inflammatory, anticancer, antidiabetic, antiasthmatic, antalgic, and anti-fatigue activities. Exercise training (ET) improves frailty resulting from aging. This study evaluated the effects of a combination RES supplementation ET on exercise performance aged mice. C57BL/6J mice (16 months old) were randomly divided into four groups: an older control group (OC group), with (RES (ET (ET+RES group). Other 10-week-old used as young (Y-Ctrl In this study,...

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Zebrafish has been recently considered an ideal vertebrate for studying developmental biology, genetics, particularly modeling tumorigenesis, angiogenesis, and regeneration xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</i> . However, when a zebrafish matures completely, its body loses transparency, thus making conventional optical imaging techniques difficult internal anatomy...

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Cerebrovascular disorders are associated with Alzheimer's disease (AD). Functional analysis of the cerebral vasculature requires an xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</i> approach to visualize blood flow in small animal brains. This paper proposes a high-frequency micro-Doppler imaging (HFμDI) technology for mapping mouse vasculature....

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect caused by neurotoxic chemotherapy. This randomized controlled trial aimed to evaluate the of manual acupuncture on CIPN. Twenty eligible breast cancer patients receiving taxane chemotherapy treatment were recruited and randomly divided into verum sham groups. Each group received 15 treatments over 9 weeks. Quantitative tactile detection thresholds measured using Semmes–Weinstein monofilament testing (SWM). The World...

Ultrafast high-frame-rate ultrasound imaging based on coherent-plane-wave compounding has been developed for many biomedical applications. Most systems typically operate at 3-15 MHz, and the image resolution this frequency range is not sufficient visualizing microstructure tissues. Therefore, purpose of study was to implement a high-frequency ultrafast operating 40 MHz.The plane-wave conventional multifocus B-mode were performed using Field II toolbox MATLAB in simulation study. In...

The development of effective pharmacological treatment abdominal aortic aneurysm (AAA) potentially offers great benefit to patients with preaneurysmal dilation by slowing the expansion aneurysms and reducing need for surgery. To date, therapeutic targets have had low efficacy. Thus, in this study, we aim elucidate possible mechanisms driving progression identify potential intervention. We demonstrate that mechanistic target rapamycin (mTOR) signaling is overactivated smooth muscle cells...

The ability to measure the elastic properties of plaques and vessels would be useful in clinical diagnoses, particularly for detecting a vulnerable plaque. This study demonstrates feasibility combination intravascular ultrasound (IVUS) acoustic radiation force elasticity imaging distribution stiffness within atherosclerotic arteries ex vivo . A dual-frequency IVUS transducer with two elements was used induce propagation shear wave (by 8.5 MHz pushing element) which could simultaneously...

Estimating the corneal elasticity can provide valuable information for pathologies and treatments. Ophthalmologic will invariably cause changes to of cornea. For example, keratoconus phototoxic effects ultraviolet radiation usually increase elasticity. This makes a quantitative estimation human cornea important ophthalmic diagnoses. The present study investigated use proposed high-resolution shear wave imaging (HR-SWI) method based on dual-element transducer (comprising an 8-MHz element...

Scars are a type of fibrous tissue that typically forms during the wound healing process to replace damaged skin. Because studies have indicated high correlation between scar stiffness and clinical symptoms, assessing mechanical properties is crucial for determining an appropriate treatment strategy evaluating treatment's efficacy. Shear wave elastography (SWE) common technique measuring elasticity. scars few millimeters thick, they thin-layer tissues, therefore, dispersion effect must be...

Most neurodegenerative diseases are highly linked with aging. The mechanical properties of the brain should be determined for predicting and diagnosing age-related diseases. A preclinical animal study is crucial neurological disease research. However, estimation elasticity different regions mouse brains remains difficult because size brain. In this paper, high-frequency ultrasound elastography (HFUSE) based on shear wave imaging was proposed mapping stiffness at ages ex vivo.For HFUSE, a...

Estimating the elasticity distribution in cornea is important because corneal usually influenced by pathologies and surgical treatments, especially for early sclerosis. Because thickness of typically less than 1 mm, high-resolution ultrasound elastography as well Lamb wave model required viscoelastic property estimation. In present study, an array high-frequency (HFUS) method based on ultrafast imaging was proposed estimating properties porcine cornea.The elastic generated external vibrator,...

Tendon stiffness plays an important role in the tendon healing process, and many studies have indicated that measuring shear wave velocity (SWV) on tendons relates to their stiffness. Because thickness of hand is a few millimeters, high-resolution imaging required for visualizing tissues. However, resolution current ultrasound elastography systems insufficient. In this study, high-frequency (HF) system proposed SWVs tendons. The HF uses external vibrator create waves Then, it 40-MHz array...

Tendon injuries lead to tendon stiffness, which impairs skeletal muscle movement. Most studies have focused on patellar or Achilles tendons by using ultrasound elastography. Only a few measured the stiffness of hand because their thickness is only 1-2 mm, rendering clinical elastography unsuitable for mapping stiffness. In this study, high-frequency shear (HFUSE) system was proposed map wave velocity (SWV) flexor tendons. A handheld vibration that coaxially mounted with an external vibrator...

Purpose Hand tendon injuries caused by various accidents are common in emergency departments. The assessment of properties is crucial for evaluating the effectiveness therapy or rehabilitation during recovery after hand injuries. Many recent studies have indicated that shear wave velocity (SWV) tendons related to their stiffness. However, measurement SWV still a challenge because small size and limitation existing ultrasound systems detecting fast SWV. Methods We propose high‐frequency...

Purpose Doppler ultrasound imaging has been used widely for diagnosing vascular diseases. Recently, vector (VDI) proposed visualizing the blood flow in all directions to yield more detailed information estimating conditions. Increasing resolution of VDI is important structural mapping superficial vessels with microstructure. However, that operates under a high‐frequency (HFUS; &gt;30 MHz) rare. In this study, 40‐MHz (HFVDI) based on ultrafast was developed obtain around venous valve. Methods...

We investigate the impact of health information exchange (HIE) use at visit level on patient outcomes, such as future behavior and number procedures performed patient, how effects differ across characteristics, for example, whether a has chronic conditions involves hospital switch. Timely sharing is expected to decrease fragmentation care improve decision‐making, diagnoses, plans, yet previous studies that examine benefits HIE do not focus these issues are unanimous in their findings general...

Ultrasound (US) shear wave elasticity imaging (SWEI) is a mature technique for diagnosing the of isotropic tissues. However, anisotropic tissues, such as muscle and tendon, cannot be diagnosed correctly using SWEI because velocity (SWV) varies with tissue fiber orientations. Recently, has been studied measuring properties muscles by rotating transducer; however, this difficult clinical practice.In study, novel dual-direction (DDSWI) was proposed visualizing mechanical anisotropy without...