A5101999955- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Plant tissue culture and regeneration
- Immune Cell Function and Interaction
- Seed Germination and Physiology
- Plant Genetic and Mutation Studies
- Fatigue and fracture mechanics
- Cell death mechanisms and regulation
- Insect and Arachnid Ecology and Behavior
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Neurobiology and Insect Physiology Research
- Plant Molecular Biology Research
- Thallium and Germanium Studies
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- Saffron Plant Research Studies
- Flavonoids in Medical Research
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Peroxisome Proliferator-Activated Receptors
- Chromosomal and Genetic Variations
- Cancer-related gene regulation
Northeast Forestry University
2012-2024
Nanjing Normal University
2024
Hebei Medical University
2018-2019
Shangluo Central Hospital
2019
Huazhong University of Science and Technology
2019
Tongji Hospital
2019
First Bethune Hospital of Jilin University
2017
University of California, Riverside
2016
Utah State University
2014
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance intra-tumoral bacteria, such us E.coli, residing and resulting Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation RIG-I suppressed recruitment NF-κB to the Nlrp3 promoter...
The pulmonary fibrosis could be caused by long-term inhalation of carbon black (CB) particles. Studies on the mechanisms induced CB are required to develop stratagem prevention and treatment fibrosis. RNA-binding protein DiGeorge syndrome critical region gene 8 (DGCR8)-dependent pri-miRNAs processing is regulated N6-methyladenosine (m6A) modification, which targets downstream signal pathway. However, its role in has not been known clearly. In present study, rats inhaled at dose 0, 5 or 30...
Circular RNA (circRNA) can modulate the gene expression via sponging microRNA (miRNA) in multiple malignancies. Nevertheless, detailed function of circ_0001658 osteosarcoma (OS) and its regulatory mechanism remain elusive. Real-time PCR was carried out to detect expressions circ_0001658, miR-382-5p, Y box-binding protein 1 (YB-1) mRNA OS tissues. Besides, western blot done monitor YB-1 cells. Chi-squared test used analyse correlation between clinicopathologic characteristics patients. CCK8...
Abstract Metabolic abnormality is the major feature of laryngeal squamous cell carcinoma (LSCC), however, underlying mechanism remain largely elusive. Fatty acid desaturase 1 (FADS1), as key rate-limiting enzyme polyunsaturated fatty acids (PUFAs), catalyzes dihomo-gamma-linolenic (DGLA) to arachidonic (AA). In this study, we reported that expression FADS1 was upregulated in LSCC, high closely associated with advanced clinical features and poor prognosis recurrent LSCC patients after...
Injury of hippocampal neurons in status epilepticus (SE) SD rats kindled by pentylenetetrazol (PTZ) were studied, and the changes apoptosis neurons, protein expression Bad Bcl-2 alone combined application phosphatidyl inositol 3-kinase (PI3K) inhibitor LY294002 recombinant human erythropoietin (rHuEpo) evaluated for possible mechanisms rHuEpo. The SE PTZ randomly divided into normal control group [normal saline (NS)], model (PTZ + NS), rHuEpo treated rHuEpo), rHuEpo) (rHuEpo DMSO). Apoptosis...
This study enhanced germanium (Ge) enrichment in the liquid fermentation of edible fungus Lyophyllum decastes order to boost its biological activity, particularly antioxidant and immunomodulatory properties. Through use single-factor Plackett–Burman designs, experiments revealed critical parameters affecting Ge enrichment, including oxide concentration, potato powder peptone levels. The optimization Box–Behnken response surface methodology resulted a concentration 3.61 mg/L, significantly...