A5025022567- Nanoparticle-Based Drug Delivery
- Microbial Inactivation Methods
- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Micro and Nano Robotics
- Toxin Mechanisms and Immunotoxins
- Microfluidic and Bio-sensing Technologies
- MicroRNA in disease regulation
- Photoacoustic and Ultrasonic Imaging
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Diabetic Foot Ulcer Assessment and Management
- Management of metastatic bone disease
- Myasthenia Gravis and Thymoma
- Healthcare professionals’ stress and burnout
- Immune cells in cancer
- Acute Kidney Injury Research
- Autophagy in Disease and Therapy
- Welding Techniques and Residual Stresses
- Ultrasound and Hyperthermia Applications
Qilu Hospital of Shandong University
2024
Jilin Medical University
2024
Jilin University
2023-2024
Chongqing Medical University
2016-2023
Fuda Cancer Hospital
2011-2023
Jinan University
2014-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2023
Dalian Medical University
2016-2021
Second Affiliated Hospital of Chongqing Medical University
2016-2021
Zhongshan Hospital of Xiamen University
2021
Magnesium (Mg) is the fourth most abundant element in human body and important terms of specific osteogenesis functions. Here, we provide a comprehensive review use magnesium-based biomaterials (MBs) bone reconstruction. We history MBs their excellent biocompatibility, biodegradability osteopromotive properties, highlighting them as candidates for new generation biodegradable orthopedic implants. In particular, results reported field-specific literature (280 articles) recent decades are...
Organic–inorganic hybrid materials have drawn increasing attention as photothermal agents in tumor therapy due to the advantages of green synthesis, high loading efficiency hydrophobic drugs, facile incorporation theranostic iron, and excellent without inert components or additives. Herein, we proposed a strategy for biomimetic engineering-mediated enhancement performance microenvironment (TME). This is based on specific characteristics organic–inorganic endows these with homologous...
The outcome of sonodynamic immunotherapy is significantly limited by tumor hypoxia.To overcome this obstacle, one common solution to catalyze the conversion endogenous H2O2 into O2.However, effectiveness strategy insufficient concentration in microenvironment (TME).Herein, we developed a economizer for on-demand O2 supply and sonosensitizer-mediated reactive oxygen species production during ultrasound activation, thereby alleviating hypoxia-associated limitations augmenting efficacy...
Abstract Malignant bone tumors result in high rates of disability and death are difficult to treat terms killing repairing defects. Compared with other hyperthermia strategies, magnetic has become an effective therapy for treating malignant due its lack depth limitations. However, tumor cells express heat shock protein (HSP) resist hyperthermia, which reduces curative effect. Competitive ATP consumption can reduce HSP production; fortunately, the basic principle starvation by glucose oxidase...
Background: Minimally invasive modalities are of great interest in the field treating bone tumors. However, providing reliable mechanical support and fast killing tumor cells to achieve rapid recovery physical function is still challenging clinical works. Methods: A material with two functions, magnetic thermal ablation, was developed from Fe3O4 nanoparticles (NPs) distributed a polymethylmethacrylate (PMMA) cement. The properties efficiency field-induced ablation were systematically...
The repair of bone defects with irregular shapes, particularly in a minimally invasive manner, remains major challenge. For synthetic grafts, injectable hydrogels are superior to conventional scaffolds because they can adapt satisfactorily the defect margins and be injected into deeper areas injury via procedure. Based on poly(lactide-co-glycolide)(PLGA)/1-methyl-2-pyrrolidinone solution reported our previous study, we successfully synthesized MgO/MgCO3@PLGA (PMM) hydrogels, namely,...
Magnetic hyperthermia is a promising minimally invasive technique for tumor therapy which has drawn much attention.
The present study investigated the clinical significance of novel biomarker neutrophil gelatinase-associated lipocalin (NGAL) for early diagnosis acute renal injury (AKI). Thirty-eight critically ill patients with treated at Zhengzhou No. 7 People's Hospital between December 2015 and November 2016 served as AKI group (observation group). At same time, 38 without were also selected non-AKI (control Serum NGAL creatinine (SCr) levels measured by enzyme-linked immunosorbent assay (ELISA) 2, 8,...
An oxygen-irrelevant free radicals generation strategy has shown great potential in hypoxic tumor therapy. However, insufficient accumulation, nonspecific intracellular localization, and the presence of highly reductive mitochondrial glutathione (GSH) dramatically hamper therapeutic efficacy. Herein, a hierarchical targeting system was constructed by Fe-doped polydiaminopyridine nanoshuttles, indocyanine green (ICG), an generator (AIPH) to possess negative charge. acid-specific...
Clear cell renal cancer (ccRCC) is a tumor of high malignancy, which can escape apoptosis. The protein p53-inducible nuclear 2 (TP53INP2), known as an autophagy protein, the essential part for autophagosome formation and sensitizes cells to Our study aimed at exploring role TP53INP2 in ccRCC. We have identified autophagy-related genes (ARGs) differential expression ccRCC patients with help TCGA database by bioinformatics analysis. assays quantitative real-time polymerase chain reaction...
Irreversible electroporation (IRE) is a novel local tumor ablation approach with the potential to stimulate an antitumor immune response. However, it not effective in preventing distant metastasis isolation. This study aimed compare of augmenting response patients locally advanced pancreatic cancer (LAPC) who underwent IRE combined chemotherapy and PD-1/PD-L1 blockade those chemotherapy.A retrospective review was conducted on LAPC treated either combination (group A) or alone B) from July...
Medical staff play a crucial role in delivering healthcare services, especially during epidemics of infectious diseases such as coronavirus disease 2019 (COVID-19). However, there is growing issue burnout and low wellbeing among this group. While it widely recognized that has negative impact on subjective wellbeing, the exact relationship between two not yet completely understood. The purpose study to explore chain mediating psychological capital perceived social support medical staff.
It is a great challenge to directly endow tumor with specific functions for theranostic treatment. In this study, we report on novel approach transform into "bio-magnet", be magnetized demand, in order create an intrinsic magnetic field that would collect nanoparticles (MNPs) circulating the blood and achieve simultaneous hyperthermia. This was achieved by localized intratumoral injection of liquid Nd2Fe14B/Fe3O4-PLGA, followed solvent exchange induces liquid-to-solid transformation. After...
Osteolytic lesions of bone tumors lead to stress-induced loss load-bearing bones, making it difficult treat and repair tissue structures. Magnetic hyperthermia has become an effective minimally invasive treatment for malignant without depth limitations. However, the effectiveness magnetic heat therapy alone is not satisfactory, if combined with chemotherapy, can significant systemic side effects. It important efficiently target chemotherapy substances correct area therapy. We have developed...
The eddy-current displacement sensor (ECDS), due to features of small size and high-measurement accuracy, has great potential for high-precision measurement in a compact space. However, most applications ECDS are one-dimensional (1D) or two-dimensional measurements. In this paper, method three-dimensional (3D) coordinates only by virtue single is proposed. order realize the 3D ECDS, virtual starting point (VDMSP) vector used as prior information obtain absolute measuring coordinate spatial...
The ablation of liver tumors located close to the gallbladder is likely lead complications. aim this article compare safety and efficacy irreversible electroporation (IRE) cryoablation in rabbit livers at a location gallbladder.We performed (n = 12) IRE area 24 New Zealand white rabbits order ensure damage. Serum aminotransferase serum bilirubin levels were measured before after ablation. Histopathological examination zones was on 7th day ablation.Seven days ablation, all animals alive....
Introduction Unresectable hilar cholangiocarcinoma (UHC) is a malignant tumor and has poor prognosis. IRE novel non-thermal ablative therapy that causes cellular apoptosis via electrical impulses. To compare the curative effect for UHC, chemotherapy plus concurrent alone were set up.Materials methods From July 2015 to May 2019, 47 patients with UHC analyzed + group (n = 23) or 24) in this study. Treatment response was assessed computed tomography (CT) magnetic resonance imaging (MRI) 1 month...